Towards mixed sequence recognition by triple helix formation
The formation of intermolecular DNA triple helices offers the possibility of designing compounds with extensive sequence recognition properties which may be useful as antigene agents or tools in molecular biology. One major limitation of this approach is that these structures are generally restricte...
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| Published in: | Nucleic acids research Vol. 27; no. 7; pp. 1569 - 1577 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Oxford University Press
01-04-1999
Oxford Publishing Limited (England) |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | The formation of intermolecular DNA triple helices offers the possibility of designing compounds with extensive sequence recognition properties which may be useful as antigene agents or tools in molecular biology. One major limitation of this approach is that these structures are generally restricted to homopurine homopyrimidine target sites. This review describes the strategies that have been employed to overcome this drawback and outlines the potential for triplex formation at mixed sequence DNA targets. |
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| Bibliography: | ark:/67375/HXZ-6LTDFG0F-V istex:B89AC1F993E35A50E9DDB2A9565FA0D9DDF92BE4 Present address: Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 |
| ISSN: | 0305-1048 1362-4962 1362-4962 |
| DOI: | 10.1093/nar/27.7.1569 |