Trypanosoma brucei Interaction with Host: Mechanism of VSG Release as Target for Drug Discovery for African Trypanosomiasis

The protozoan , responsible for animal and human trypanosomiasis, has a family of major surface proteases (MSPs) and phospholipase-C (PLC), both involved in some mechanisms of virulence during mammalian infections. During parasitism in the mammalian host, this protozoan is exclusively extracellular...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 20; no. 6; p. 1484
Main Authors:	Moreno, Cláudia Jassica Gonçalves, Temporão, Adriana, Torres, Taffarel, Sousa Silva, Marcelo
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 25-03-2019 MDPI
Subjects:	African trypanosomiasis antigenic variation Brain Drugs Glycoproteins Immune system Immunoglobulins Infections Kinases major surface protease Parasites Pentamidine phospholipase-C Proteins Review Suramin Trypanosoma brucei Vaccines variable surface glycoprotein major surface protease antigenic variation variable surface glycoprotein Trypanosoma brucei phospholipase-C
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