Epigallocatechin Gallate Protects against Hypoxia-Induced Inflammation in Microglia via NF-κB Suppression and Nrf-2/HO-1 Activation

Hypoxia-induced neuroinflammation in stroke, neonatal hypoxic encephalopathy, and other diseases subsequently contributes to neurological damage and neuronal diseases. Microglia are the primary neuroimmune cells that play a crucial role in cerebral inflammation. Epigallocatechin gallate (EGCG) has a...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 23; no. 7; p. 4004
Main Authors:	Kim, So-Ra, Seong, Kyung-Joo, Kim, Won-Jae, Jung, Ji-Yeon
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 04-04-2022 MDPI
Subjects:	Alzheimer's disease Antioxidants Apoptosis Caspase-3 Catechin - analogs & derivatives Catechin - pharmacology Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines Cytotoxicity Encephalopathy Epigallocatechin gallate GA-binding protein Humans Hypoxia Hypoxia, Brain - metabolism Hypoxia-inducible factor 1a Inflammation Inflammation - drug therapy Inflammation - metabolism Interleukin 6 Interleukin-6 - metabolism Kinases Lipopolysaccharides Microglia Microglia - metabolism Neonates NF-kappa B - metabolism NF-κB NF-κB protein Nitric oxide Nitric-oxide synthase Oxidative stress Poly(ADP-ribose) polymerase Polyphenols Prostaglandin endoperoxide synthase Proteins Reactive Oxygen Species - metabolism Ribose Tea Traumatic brain injury Tumor necrosis factor-TNF NF-κB hypoxia epigallocatechin gallate inflammation microglia
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