Development of a Genome-Scale Metabolic Model and Phenome Analysis of the Probiotic Escherichia coli Strain Nissle 1917

Nissle 1917 (EcN) is an intestinal probiotic that is effective for the treatment of intestinal disorders, such as inflammatory bowel disease and ulcerative colitis. EcN is a representative Gram-negative probiotic in biomedical research and is an intensively studied probiotic. However, to date, its g...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 22; no. 4; p. 2122
Main Authors:	Kim, Dohyeon, Kim, Youngshin, Yoon, Sung Ho
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 20-02-2021 MDPI
Subjects:	Acids Anaerobic conditions Anaerobiosis Antibiotics Antigens Biosynthesis Carbon Carbon - pharmacology Computer Simulation Digestive system DNA microarrays Drug development E coli Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - growth & development Escherichia coli - metabolism Escherichia coli Nissle 1917 flux balance analysis Genes Genome, Bacterial Genomes Genotype & phenotype Growth conditions Inflammatory bowel diseases Inflammatory diseases Intestine Intestines - microbiology Metabolic Flux Analysis metabolic network model Metabolic networks Metabolic Networks and Pathways - drug effects Metabolic Networks and Pathways - genetics Metabolism Metabolites Microbiota Microorganisms Models, Biological Multigene Family Nitrogen Nitrogen - pharmacology Nutrient sources Optimization techniques phenome analysis Phenomics Phenotype Phenotypes Probiotics Probiotics - metabolism Reproducibility of Results Simulation Sodium Ulcerative colitis metabolic network model flux balance analysis phenome analysis Escherichia coli Nissle 1917 probiotics
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