Meta-analysis of the frequency of intrauterine growth restriction and preterm premature rupture of the membranes in pregnant women with COVID-19

• Published in: Turkish journal of obstetrics and gynecology Vol. 18; no. 3; pp. 236 - 244
• Main Authors: Bahrami, Reza, Schwartz, David A, Karimi-Zarchi, Mojgan, Javaheri, Atiyeh, Dastgheib, Seyed Alireza, Ferdosian, Farzad, Noorishadkam, Mahmood, Mirjalili, Seyed Reza, Neamatzadeh, Hossein
• Format: Journal Article
• Language: English
• Published: Turkey Türk Jinekoloji ve Obstetrik Derneği 27-09-2021; Galenos Publishing House; Galenos Publishing
• Subjects: Asian people; Bias; Case reports; COVID-19; Disease transmission; Epidemics; Ethnicity; Fetuses; Infections; Kadın Hastalıkları; Meta-analysis; Pregnancy; Premature birth; Review; Sensitivity analysis; Severe acute respiratory syndrome coronavirus 2; Tıp; Viral infections; White people; Womens health; Ankara; Türkiye; United States > US; China; COVID-19; preterm premature rupture of membranes; intrauterine growth restriction; SARS-CoV-2; pregnancy; gebelik; intrauterin büyüme geriliği; preterm erken membran rüptürü
• ISSN: 2149-9322; 2149-9330
• DOI: 10.4274/tjod.galenos.2021.74829

The impact of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in pregnancy has yet to be determined. Some studies indicate that SARSCoV- 2 infection may be associated with a higher risk of adverse outcomes in pregnant women. Here, we performed a meta-analysis to estimate the frequency of intrauterine growth restriction (IUGR) and preterm premature rupture of the membranes (PPROM) in pregnant women with Coronavirus disease-2019 (COVID-19). A comprehensive search was performed in various databases, such as PubMed, Scopus, SciELO, MedRxiv, and Web of Science, to find all relevant studies published before 10 February 2021. Cross-sectional and consecutive case series reporting the pregnancy outcomes of COVID-19 were included. A total of 24 studies, including 8 studies on IUGR and 16 studies on PPROM, were selected. Pooled data showed that the frequencies of IUGR and PPROM in pregnant women with COVID-19 were 2.6% and 9.9%, respectively. Analyses stratified by ethnicity showed that the frequencies of IUGR in Asian and Caucasian COVID-19-infected pregnant women were 2.9% and 2.0%, respectively. Moreover, the frequencies of PPROM in Asian and Caucasian COVID-19-infected pregnant women were 10.2% and 5.8%, respectively. This meta-analysis showed that the frequencies of IUGR and PPROM in COVID-19-infected pregnant women were 2.6% and 9.9%, respectively. However, well-designed, large-scale and multicenter clinical studies are required to improve and validate these results.