Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery of genes involved in the metabolism of xenobiotics and endogenous compounds. AhR is a ligand-activated transcription factor necessary for the launch of transcriptional responses important in health and disease...

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Published in:International journal of molecular sciences Vol. 23; no. 12; p. 6719
Main Authors: Grishanova, Alevtina Y, Perepechaeva, Maria L
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 16-06-2022
MDPI
Subjects:
AhR
antioxidant
Antioxidants
Aromatic compounds
aryl hydrocarbon receptor
Binding sites
Cell cycle
Chemical compounds
Cytochrome
Cytochrome P450
Cytochromes P450
Dioxins
Enzymes
Flavonoids
Free radicals
Gene expression
Gene Expression Regulation
Genes
Homeostasis
Humans
Ligands
Metabolic activation
Metabolic rate
Metabolism
Metabolites
Nitric oxide
nuclear factor-erythroid 2-related factor 2
Oxidative Stress
Pathogenesis
PCB
Pharmacology
Physiology
Pollutants
Polychlorinated biphenyls
Polycyclic aromatic hydrocarbons
Proteins
reactive oxygen species
Reactive Oxygen Species - metabolism
Receptors, Aryl Hydrocarbon - genetics
Receptors, Aryl Hydrocarbon - metabolism
Review
Signal transduction
Xenobiotics
Xenobiotics - metabolism
nuclear factor-erythroid 2-related factor 2
antioxidant
Nrf2
reactive oxygen species
AhR
oxidative stress
aryl hydrocarbon receptor
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Abstract The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery of genes involved in the metabolism of xenobiotics and endogenous compounds. AhR is a ligand-activated transcription factor necessary for the launch of transcriptional responses important in health and disease. In past decades, evidence has accumulated that AhR is associated with the cellular response to oxidative stress, and this property of AhR must be taken into account during investigations into a mechanism of action of xenobiotics that is able to activate AhR or that is susceptible to metabolic activation by enzymes encoded by the genes that are under the control of AhR. In this review, we examine various mechanisms by which AhR takes part in the oxidative-stress response, including antioxidant and prooxidant enzymes and cytochrome P450. We also show that AhR, as a participant in the redox balance and as a modulator of redox signals, is being increasingly studied as a target for a new class of therapeutic compounds and as an explanation for the pathogenesis of some disorders.
AbstractList The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery of genes involved in the metabolism of xenobiotics and endogenous compounds. AhR is a ligand-activated transcription factor necessary for the launch of transcriptional responses important in health and disease. In past decades, evidence has accumulated that AhR is associated with the cellular response to oxidative stress, and this property of AhR must be taken into account during investigations into a mechanism of action of xenobiotics that is able to activate AhR or that is susceptible to metabolic activation by enzymes encoded by the genes that are under the control of AhR. In this review, we examine various mechanisms by which AhR takes part in the oxidative-stress response, including antioxidant and prooxidant enzymes and cytochrome P450. We also show that AhR, as a participant in the redox balance and as a modulator of redox signals, is being increasingly studied as a target for a new class of therapeutic compounds and as an explanation for the pathogenesis of some disorders.
Author Perepechaeva, Maria L
Grishanova, Alevtina Y
AuthorAffiliation Federal Research Center of Fundamental and Translational Medicine, Institute of Molecular Biology and Biophysics, Timakova Str. 2, 630117 Novosibirsk, Russia; agrish@niimbb.ru
AuthorAffiliation_xml – name: Federal Research Center of Fundamental and Translational Medicine, Institute of Molecular Biology and Biophysics, Timakova Str. 2, 630117 Novosibirsk, Russia; agrish@niimbb.ru
Author_xml – sequence: 1
  givenname: Alevtina Y
  orcidid: 0000-0002-5894-1159
  surname: Grishanova
  fullname: Grishanova, Alevtina Y
  organization: Federal Research Center of Fundamental and Translational Medicine, Institute of Molecular Biology and Biophysics, Timakova Str. 2, 630117 Novosibirsk, Russia
– sequence: 2
  givenname: Maria L
  orcidid: 0000-0001-5791-3714
  surname: Perepechaeva
  fullname: Perepechaeva, Maria L
  organization: Federal Research Center of Fundamental and Translational Medicine, Institute of Molecular Biology and Biophysics, Timakova Str. 2, 630117 Novosibirsk, Russia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35743162$$D View this record in MEDLINE/PubMed
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Keywords nuclear factor-erythroid 2-related factor 2
antioxidant
Nrf2
reactive oxygen species
AhR
oxidative stress
aryl hydrocarbon receptor
Language English
License Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Snippet The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery of genes involved in the metabolism of xenobiotics and endogenous...
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SubjectTerms AhR
antioxidant
Antioxidants
Aromatic compounds
aryl hydrocarbon receptor
Binding sites
Cell cycle
Chemical compounds
Cytochrome
Cytochrome P450
Cytochromes P450
Dioxins
Enzymes
Flavonoids
Free radicals
Gene expression
Gene Expression Regulation
Genes
Homeostasis
Humans
Ligands
Metabolic activation
Metabolic rate
Metabolism
Metabolites
Nitric oxide
nuclear factor-erythroid 2-related factor 2
Oxidative Stress
Pathogenesis
PCB
Pharmacology
Physiology
Pollutants
Polychlorinated biphenyls
Polycyclic aromatic hydrocarbons
Proteins
reactive oxygen species
Reactive Oxygen Species - metabolism
Receptors, Aryl Hydrocarbon - genetics
Receptors, Aryl Hydrocarbon - metabolism
Review
Signal transduction
Xenobiotics
Xenobiotics - metabolism
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Title Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance
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