Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats

• Published in: International journal of molecular sciences Vol. 19; no. 3; p. 700
• Main Authors: Ikarashi, Nobutomo, Toda, Takahiro, Hatakeyama, Yusuke, Kusunoki, Yoshiki, Kon, Risako, Mizukami, Nanaho, Kaneko, Miho, Ogawa, Sosuke, Sugiyama, Kiyoshi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-03-2018; MDPI
• Subjects: acacia polyphenol; Angiotensin; Antihypertensives; Atopic dermatitis; Blood pressure; Dermatitis; Diabetes mellitus; Hypertension; Kidneys; NAD(P)H oxidase; NADPH-diaphorase; Nicotinamide; nicotinamide adenine dinucleotide phosphate oxidase; Oxidation; Peptidyl-dipeptidase A; Pressure effects; Rats; Rodents; Superoxide dismutase; hypertension; nicotinamide adenine dinucleotide phosphate oxidase; acacia polyphenol; superoxide dismutase
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms19030700

We have previously demonstrated that acacia polyphenol (AP) exerts strong anti-obesity, anti-diabetic, and anti-atopic dermatitis effects. In the present study, we investigated the anti-hypertensive effects of AP. Spontaneously hypertensive rats (SHR) with hypertension and control Wistar Kyoto rats (WKY) were used. WKY and SHR were fed AP-containing food or AP-free food (control group) ad libitum for 4 weeks, and their blood pressures were measured. After AP administration, both systolic and diastolic blood pressures were significantly lower in the SHR group than in the control group. There were no differences in the systolic or diastolic blood pressure of WKY between the AP group and the control group. Angiotensin-converting enzyme (ACE) activity,
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expression, and superoxide dismutase (SOD) activity in SHR kidneys were not altered by AP administration. Blood SOD activity in SHR was significantly higher in the AP group than in the control group. AP exerts anti-hypertensive effects on hypertension but has almost no effect on normal blood pressure. The anti-hypertensive effects of AP may be related to the anti-oxidative effects of increased blood SOD activity.