Biocompatible and Antimicrobial Electrospun Membranes Based on Nanocomposites of Chitosan/Poly (Vinyl Alcohol)/Graphene Oxide
Tissue engineering is gaining attention rapidly to replace and repair defective tissues in the human body after illnesses and accidents in different organs. Electrospun nanofiber scaffolds have emerged as a potential alternative for cell regeneration and organ replacement. In this paper, porous memb...
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| Published in: | International journal of molecular sciences Vol. 20; no. 12; p. 2987 |
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| Abstract | Tissue engineering is gaining attention rapidly to replace and repair defective tissues in the human body after illnesses and accidents in different organs. Electrospun nanofiber scaffolds have emerged as a potential alternative for cell regeneration and organ replacement. In this paper, porous membranes, based on nanofibrous chitosan (CS), polyvinyl alcohol (PVA), and graphene oxide (GO), were obtained via electrospinning methodology. Three different formulations were obtained varying GO content, being characterized by Fourier Transform Infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS). In vitro tests were carried out, consisting of hydrolytic degradation inside simulated biological fluid (SBF), and in vivo tests were carried out, where the material was implanted in Wistar rats' subcutaneous tissue to determine its biocompatibility. The antibacterial activity was tested against Gram-positive bacteria
and
and against Gram-negative
and
, by contact of the electrospun nanofiber scaffolds above inoculum bacterial in Müeller Hinton agar with good inhibition only for scaffolds with the higher GO content (1.0%). The results confirmed good biocompatibility of the nanofibrous scaffolds after in vivo tests in Wistar rats, which evidences its high potential in applications of tissue regeneration. |
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| AbstractList | Tissue engineering is gaining attention rapidly to replace and repair defective tissues in the human body after illnesses and accidents in different organs. Electrospun nanofiber scaffolds have emerged as a potential alternative for cell regeneration and organ replacement. In this paper, porous membranes, based on nanofibrous chitosan (CS), polyvinyl alcohol (PVA), and graphene oxide (GO), were obtained via electrospinning methodology. Three different formulations were obtained varying GO content, being characterized by Fourier Transform Infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS). In vitro tests were carried out, consisting of hydrolytic degradation inside simulated biological fluid (SBF), and in vivo tests were carried out, where the material was implanted in Wistar rats’ subcutaneous tissue to determine its biocompatibility. The antibacterial activity was tested against Gram-positive bacteria
Bacillus
cereus
and
Staphylococcus
aureus,
and against Gram-negative
Salmonella
enterica
and
Escherichia
coli
, by contact of the electrospun nanofiber scaffolds above inoculum bacterial in Müeller Hinton agar with good inhibition only for scaffolds with the higher GO content (1.0%). The results confirmed good biocompatibility of the nanofibrous scaffolds after in vivo tests in Wistar rats, which evidences its high potential in applications of tissue regeneration. For this reason, it is necessary to reinforce the mechanical and thermal properties of the materials used as scaffolds with nanocomposites, which can increase mechanical and thermal resistance, as well as the barrier and antimicrobial properties. [...]the development of nanocomposites based on biopolymers, such as chitosan (CS), thanks to its biocompatibility, biodegradability, physiological inertness, remarkable affinity to proteins, and antibacterial, hemostatic, fungistatic, and antitumor properties, becomes an excellent alternative for the design of biomaterials for cell regeneration [4]. Micro/nanofibrous scaffolds have been investigated extensively for tissue engineering and drug delivery [24]. Since micro/nanofibrous scaffolds mimic the natural extracellular matrix (ECM), they stimulate cell adhesion, proliferation, migration, and differentiation better than particulate structures. Even though several studies on CS/ polyvinyl alcohol (PVA)/GO films and electrospun polymeric micro/nanofibrous scaffolds have been investigated extensively in the literature, there is a lack of information about the physical, chemical, and mechanical characterization of the nanofibrous membranes, and their biocompatibility and antimicrobial performance. [...]this research proposed the study of biodegradable nanofibrous membranes based on PVA/CS/GO with potential applications for tissue regeneration and antimicrobial devices. 2. The weight loss was lower for the samples with higher GO content, the samples with 0% GO presented a final degradation of 75.4%, which is higher in comparison with the samples that contained some percentage of GO: the scaffolds with 0.5% GO exhibited an ultimate degradation of 72.33% and the frameworks with 1% GO showed the lowest deterioration of 71.90%. [...]it was observed that with a higher content of GO there is a lower weight loss, attributed to the higher content of GO in the CS/PVA binary mixture due to hydrogen bonds with the CS. Tissue engineering is gaining attention rapidly to replace and repair defective tissues in the human body after illnesses and accidents in different organs. Electrospun nanofiber scaffolds have emerged as a potential alternative for cell regeneration and organ replacement. In this paper, porous membranes, based on nanofibrous chitosan (CS), polyvinyl alcohol (PVA), and graphene oxide (GO), were obtained via electrospinning methodology. Three different formulations were obtained varying GO content, being characterized by Fourier Transform Infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS). In vitro tests were carried out, consisting of hydrolytic degradation inside simulated biological fluid (SBF), and in vivo tests were carried out, where the material was implanted in Wistar rats' subcutaneous tissue to determine its biocompatibility. The antibacterial activity was tested against Gram-positive bacteria Bacillus cereus and Staphylococcus aureus, and against Gram-negative Salmonella enterica and Escherichia coli, by contact of the electrospun nanofiber scaffolds above inoculum bacterial in Müeller Hinton agar with good inhibition only for scaffolds with the higher GO content (1.0%). The results confirmed good biocompatibility of the nanofibrous scaffolds after in vivo tests in Wistar rats, which evidences its high potential in applications of tissue regeneration. Tissue engineering is gaining attention rapidly to replace and repair defective tissues in the human body after illnesses and accidents in different organs. Electrospun nanofiber scaffolds have emerged as a potential alternative for cell regeneration and organ replacement. In this paper, porous membranes, based on nanofibrous chitosan (CS), polyvinyl alcohol (PVA), and graphene oxide (GO), were obtained via electrospinning methodology. Three different formulations were obtained varying GO content, being characterized by Fourier Transform Infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS). In vitro tests were carried out, consisting of hydrolytic degradation inside simulated biological fluid (SBF), and in vivo tests were carried out, where the material was implanted in Wistar rats' subcutaneous tissue to determine its biocompatibility. The antibacterial activity was tested against Gram-positive bacteria and and against Gram-negative and , by contact of the electrospun nanofiber scaffolds above inoculum bacterial in Müeller Hinton agar with good inhibition only for scaffolds with the higher GO content (1.0%). The results confirmed good biocompatibility of the nanofibrous scaffolds after in vivo tests in Wistar rats, which evidences its high potential in applications of tissue regeneration. |
| Author | Londoño, Sebastián Ruiz Mina Hernandez, José Herminsul Delgado, Johannes Valencia, Carlos Humberto Grande Tovar, Carlos David Tamayo Marín, Julián Andrés Valencia Zapata, Mayra Eliana Navia Porras, Diana Paola |
| AuthorAffiliation | 4 Programa de Química, Facultad de Ciencias, Universidad del Atlántico, Carrera 30 Número 8-49, Puerto Colombia 081008, Colombia 1 Escuela de Ingeniería de Materiales, Facultad de Ingeniería, Universidad del Valle, Calle 13 No. 100-00, Santiago de Cali 760032, Colombia; julian.tamayo@correounivalle.edu.co (J.A.T.M.); sebastian.ruiz.londono@correounivalle.edu.co (S.R.L.); valencia.mayra@correounivalle.edu.co (M.E.V.Z.); jose.mina@correounivalle.edu.co (J.H.M.H.) 2 Grupo de Investigación Biotecnología, Facultad de Ingeniería, Universidad de San Buenaventura Cali, Carrera 122 No. 6-65, Cali 76001, Colombia; jdelgado1@usbcali.edu.co (J.D.); dpnavia@usbcali.edu.co (D.P.N.P.) 3 Escuela de Odontología, Grupo biomateriales dentales, Universidad del Valle, Calle 13 No. 100-00, Cali 76001, Colombia; carlos.humberto.valencia@correounivalle.edu.co |
| AuthorAffiliation_xml | – name: 3 Escuela de Odontología, Grupo biomateriales dentales, Universidad del Valle, Calle 13 No. 100-00, Cali 76001, Colombia; carlos.humberto.valencia@correounivalle.edu.co – name: 4 Programa de Química, Facultad de Ciencias, Universidad del Atlántico, Carrera 30 Número 8-49, Puerto Colombia 081008, Colombia – name: 2 Grupo de Investigación Biotecnología, Facultad de Ingeniería, Universidad de San Buenaventura Cali, Carrera 122 No. 6-65, Cali 76001, Colombia; jdelgado1@usbcali.edu.co (J.D.); dpnavia@usbcali.edu.co (D.P.N.P.) – name: 1 Escuela de Ingeniería de Materiales, Facultad de Ingeniería, Universidad del Valle, Calle 13 No. 100-00, Santiago de Cali 760032, Colombia; julian.tamayo@correounivalle.edu.co (J.A.T.M.); sebastian.ruiz.londono@correounivalle.edu.co (S.R.L.); valencia.mayra@correounivalle.edu.co (M.E.V.Z.); jose.mina@correounivalle.edu.co (J.H.M.H.) |
| Author_xml | – sequence: 1 givenname: Julián Andrés surname: Tamayo Marín fullname: Tamayo Marín, Julián Andrés email: julian.tamayo@correounivalle.edu.co organization: Escuela de Ingeniería de Materiales, Facultad de Ingeniería, Universidad del Valle, Calle 13 No. 100-00, Santiago de Cali 760032, Colombia. julian.tamayo@correounivalle.edu.co – sequence: 2 givenname: Sebastián Ruiz surname: Londoño fullname: Londoño, Sebastián Ruiz email: sebastian.ruiz.londono@correounivalle.edu.co organization: Escuela de Ingeniería de Materiales, Facultad de Ingeniería, Universidad del Valle, Calle 13 No. 100-00, Santiago de Cali 760032, Colombia. sebastian.ruiz.londono@correounivalle.edu.co – sequence: 3 givenname: Johannes orcidid: 0000-0001-8095-4741 surname: Delgado fullname: Delgado, Johannes email: jdelgado1@usbcali.edu.co organization: Grupo de Investigación Biotecnología, Facultad de Ingeniería, Universidad de San Buenaventura Cali, Carrera 122 No. 6-65, Cali 76001, Colombia. jdelgado1@usbcali.edu.co – sequence: 4 givenname: Diana Paola surname: Navia Porras fullname: Navia Porras, Diana Paola email: dpnavia@usbcali.edu.co organization: Grupo de Investigación Biotecnología, Facultad de Ingeniería, Universidad de San Buenaventura Cali, Carrera 122 No. 6-65, Cali 76001, Colombia. dpnavia@usbcali.edu.co – sequence: 5 givenname: Mayra Eliana surname: Valencia Zapata fullname: Valencia Zapata, Mayra Eliana email: valencia.mayra@correounivalle.edu.co organization: Escuela de Ingeniería de Materiales, Facultad de Ingeniería, Universidad del Valle, Calle 13 No. 100-00, Santiago de Cali 760032, Colombia. valencia.mayra@correounivalle.edu.co – sequence: 6 givenname: José Herminsul surname: Mina Hernandez fullname: Mina Hernandez, José Herminsul email: jose.mina@correounivalle.edu.co organization: Escuela de Ingeniería de Materiales, Facultad de Ingeniería, Universidad del Valle, Calle 13 No. 100-00, Santiago de Cali 760032, Colombia. jose.mina@correounivalle.edu.co – sequence: 7 givenname: Carlos Humberto orcidid: 0000-0003-4892-9786 surname: Valencia fullname: Valencia, Carlos Humberto email: carlos.humberto.valencia@correounivalle.edu.co organization: Escuela de Odontología, Grupo biomateriales dentales, Universidad del Valle, Calle 13 No. 100-00, Cali 76001, Colombia. carlos.humberto.valencia@correounivalle.edu.co – sequence: 8 givenname: Carlos David orcidid: 0000-0002-6243-4571 surname: Grande Tovar fullname: Grande Tovar, Carlos David email: carlosgrande@mail.uniatlantico.edu.co organization: Programa de Química, Facultad de Ciencias, Universidad del Atlántico, Carrera 30 Número 8-49, Puerto Colombia 081008, Colombia. carlosgrande@mail.uniatlantico.edu.co |
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| Copyright | 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2019 by the authors. 2019 |
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| Keywords | chitosan graphene oxide antibacterial nanofibrous membranes electrospinning polyvinyl alcohol |
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| Title | Biocompatible and Antimicrobial Electrospun Membranes Based on Nanocomposites of Chitosan/Poly (Vinyl Alcohol)/Graphene Oxide |
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