Diastereoselective synthesis of vicinal amino alcohols

Diastereoselective synthesis of vicinal amino alcohols

The vicinal amino alcohol is a common motif in natural products and pharmaceuticals. Amino acids constitute a natural, inexpensive, and enantiopure choice of starting material for the synthesis of such functionalities. However, the matters concerning diastereoselectivity are not obvious. This Perspe...

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Bibliographic Details
Published in:Organic & biomolecular chemistry Vol. 10; no. 22; p. 4311
Main Authors: Karjalainen, Oskari K, Koskinen, Ari M P
Format: Journal Article
Language:English
Published: England 14-06-2012
Subjects:
Aldehydes - chemical synthesis
Amino Alcohols - chemical synthesis
Glucosides - chemistry
Molecular Structure
Oxidation-Reduction
Pyrimidinones - chemistry
Stereoisomerism
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Summary:The vicinal amino alcohol is a common motif in natural products and pharmaceuticals. Amino acids constitute a natural, inexpensive, and enantiopure choice of starting material for the synthesis of such functionalities. However, the matters concerning diastereoselectivity are not obvious. This Perspective takes a look in the field of diastereoselective synthesis of vicinal amino alcohols starting from amino acids using various methods.
ISSN:1477-0539
DOI:10.1039/c2ob25357g