The Aggregation of Au Nanoparticles by an Autonomous DNA Machine Detects Viruses

Virus scanner: A DNA‐based machine that performs a mechanical operation, such as scission or replication, can be used to stimulate the aggregation of Au NPs (see TEM image). The process allows the colorimetric imaging of the machine functions and the optical readout of DNA biosensing, with a sensiti...

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Bibliographic Details
Published in:	Small (Weinheim an der Bergstrasse, Germany) Vol. 3; no. 3; pp. 375 - 379
Main Authors:	Beissenhirtz, Moritz K., Elnathan, Roey, Weizmann, Yossi, Willner, Itamar
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 05-03-2007 WILEY‐VCH Verlag
Subjects:	aggregation Biosensing Techniques - instrumentation Biosensing Techniques - methods biosensors DNA DNA - chemistry DNA - genetics DNA, Viral - analysis DNA, Viral - genetics Equipment Design Equipment Failure Analysis gold Gold - chemistry nanoparticles Nanotechnology - instrumentation Nanotechnology - methods Oligonucleotide Array Sequence Analysis - instrumentation Oligonucleotide Array Sequence Analysis - methods Viruses - genetics Viruses - isolation & purification
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Summary:	Virus scanner: A DNA‐based machine that performs a mechanical operation, such as scission or replication, can be used to stimulate the aggregation of Au NPs (see TEM image). The process allows the colorimetric imaging of the machine functions and the optical readout of DNA biosensing, with a sensitivity limit corresponding to 1×10−12 M.
Bibliography:	istex:CC44B9F2434E176BA687844270A0042D20778C86 ark:/67375/WNG-H9MGLP98-Z This research is supported by the Johnson & Johnson Fund for Innovative Research. ArticleID:SMLL200600450 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.200600450