MIPgen: optimized modeling and design of molecular inversion probes for targeted resequencing

Molecular inversion probes (MIPs) enable cost-effective multiplex targeted gene resequencing in large cohorts. However, the design of individual MIPs is a critical parameter governing the performance of this technology with respect to capture uniformity and specificity. MIPgen is a user-friendly pac...

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Bibliographic Details

Published in:	Bioinformatics (Oxford, England) Vol. 30; no. 18; pp. 2670 - 2672
Main Authors:	Boyle, Evan A, O'Roak, Brian J, Martin, Beth K, Kumar, Akash, Shendure, Jay
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 15-09-2014
Subjects:	Algorithms Applications Notes Computational Biology - methods Computer Simulation DNA Probes - genetics Humans Models, Statistical Sequence Analysis - methods
Online Access:	Get full text
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