Hippocampal expression of a virus-derived protein impairs memory in mice

The analysis of the biology of neurotropic viruses, notably of their interference with cellular signaling, provides a useful tool to get further insight into the role of specific pathways in the control of behavioral functions. Here, we exploited the natural property of a viral protein identified as...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 115; no. 7; pp. 1611 - 1616
Main Authors:	Bétourné, Alexandre, Szelechowski, Marion, Thouard, Anne, Abrial, Erika, Jean, Arnaud, Zaidi, Falek, Foret, Charlotte, Bonnaud, Emilie M., Charlier, Caroline M., Suberbielle, Elsa, Malnou, Cécile E., Granon, Sylvie, Rampon, Claire, Gonzalez-Dunia, Daniel
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 13-02-2018
Subjects:	Animals Anxiety Behavioral plasticity Biological Sciences Borna disease Borna Disease - metabolism Borna Disease - pathology Borna Disease - virology Borna disease virus - physiology Cells Cells, Cultured Cognition Disorders - etiology Cognition Disorders - metabolism Cognition Disorders - pathology Dentate gyrus Dentate Gyrus - metabolism Dentate Gyrus - pathology Dentate Gyrus - virology Hippocampus Hippocampus - metabolism Hippocampus - pathology Hippocampus - virology Human health and pathology Immunological memory Infections Infectious diseases Life Sciences Long term memory Memory Memory tasks Memory, Long-Term - physiology Mental task performance Mice Mutation Neuronal Plasticity Neurons - metabolism Neurons - pathology Neurons - virology P protein Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Protein kinase C Protein Kinase C - genetics Protein Kinase C - metabolism Proteins Rodents Signaling Spatial analysis Spatial memory Substrates Synaptic plasticity Viral infections Viral Structural Proteins - genetics Viral Structural Proteins - metabolism Viruses dentate gyrus memory hippocampus virus protein kinase C
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