Activation of P2Y receptor enhances high-molecular compound absorption from rat ileum
While there are no reports concerning the effects of extracellular nucleotides on the intestinal absorption of drugs, it is well known that extracellular nucleotides are important regulators of intestinal epithelial ion transport. This report using fluorescein isothiocyanate dextran 4000 (FD‐4) as t...
Saved in:
| Published in: | Journal of pharmacy and pharmacology Vol. 58; no. 2; pp. 195 - 200 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Oxford, UK
Blackwell Publishing Ltd
01-02-2006
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | While there are no reports concerning the effects of extracellular nucleotides on the intestinal absorption of drugs, it is well known that extracellular nucleotides are important regulators of intestinal epithelial ion transport. This report using fluorescein isothiocyanate dextran 4000 (FD‐4) as the model compound is the first to investigate the effects of purine nucleotides on absorption of poorly absorbed drugs from intestine. ATP enhanced the absorption of FD‐4 from rat ileum in a concentration‐dependent manner. ADP also enhanced the absorption of FD‐4. Other purine nucleotides (adenosine, AMP, UTP and UDP) did not show an absorption‐enhancing effect. The absorption‐enhancing effect by ATP was inhibited by suramin and pyridoxalphosphate‐6‐azophenyl‐2′,4′‐disulfonate (PPADS), which are known P2 receptor antagonists. Additionally, 2‐methylthio ATP (a P2Y receptor agonist) enhanced the absorption of FD‐4, but α,β‐methylene ATP (a P2X receptor agonist) did not. These findings suggest that activation of the P2Y receptor may improve the absorption of water‐soluble and high‐molecular compounds from the ileum. |
|---|---|
| AbstractList | While there are no reports concerning the effects of extracellular nucleotides on the intestinal absorption of drugs, it is well known that extracellular nucleotides are important regulators of intestinal epithelial ion transport. This report using fluorescein isothiocyanate dextran 4000 (FD‐4) as the model compound is the first to investigate the effects of purine nucleotides on absorption of poorly absorbed drugs from intestine. ATP enhanced the absorption of FD‐4 from rat ileum in a concentration‐dependent manner. ADP also enhanced the absorption of FD‐4. Other purine nucleotides (adenosine, AMP, UTP and UDP) did not show an absorption‐enhancing effect. The absorption‐enhancing effect by ATP was inhibited by suramin and pyridoxalphosphate‐6‐azophenyl‐2′,4′‐disulfonate (PPADS), which are known P2 receptor antagonists. Additionally, 2‐methylthio ATP (a P2Y receptor agonist) enhanced the absorption of FD‐4, but α,β‐methylene ATP (a P2X receptor agonist) did not. These findings suggest that activation of the P2Y receptor may improve the absorption of water‐soluble and high‐molecular compounds from the ileum. While there are no reports concerning the effects of extracellular nucleotides on the intestinal absorption of drugs, it is well known that extracellular nucleotides are important regulators of intestinal epithelial ion transport. This report using fluorescein isothiocyanate dextran 4000 (FD-4) as the model compound is the first to investigate the effects of purine nucleotides on absorption of poorly absorbed drugs from intestine. ATP enhanced the absorption of FD-4 from rat ileum in a concentration-dependent manner. ADP also enhanced the absorption of FD-4. Other purine nucleotides (adenosine, AMP, UTP and UDP) did not show an absorption-enhancing effect. The absorption-enhancing effect by ATP was inhibited by suramin and pyridoxalphosphate-6-azophenyl-2',4'-disulfonate (PPADS), which are known P2 receptor antagonists. Additionally, 2-methylthio ATP (a P2Y receptor agonist) enhanced the absorption of FD-4, but alpha,beta-methylene ATP (a P2X receptor agonist) did not. These findings suggest that activation of the P2Y receptor may improve the absorption of water-soluble and high-molecular compounds from the ileum. |
| Author | Takahashi, Koichi Shinozuka, Kazumasa Tada, Shoko Mizuno, Nobuyasu Kinoshita, Natsumi Takahashi, Tomoko |
| Author_xml | – sequence: 1 givenname: Natsumi surname: Kinoshita fullname: Kinoshita, Natsumi organization: Departments of Pharmaceutics and Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien, Kyuban-cho, Nishinomiya 663-8179, Japan – sequence: 2 givenname: Tomoko surname: Takahashi fullname: Takahashi, Tomoko organization: Departments of Pharmaceutics and Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien, Kyuban-cho, Nishinomiya 663-8179, Japan – sequence: 3 givenname: Shoko surname: Tada fullname: Tada, Shoko organization: Departments of Pharmaceutics and Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien, Kyuban-cho, Nishinomiya 663-8179, Japan – sequence: 4 givenname: Kazumasa surname: Shinozuka fullname: Shinozuka, Kazumasa organization: Departments of Pharmaceutics and Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien, Kyuban-cho, Nishinomiya 663-8179, Japan – sequence: 5 givenname: Nobuyasu surname: Mizuno fullname: Mizuno, Nobuyasu organization: Departments of Pharmaceutics and Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien, Kyuban-cho, Nishinomiya 663-8179, Japan – sequence: 6 givenname: Koichi surname: Takahashi fullname: Takahashi, Koichi email: koichi@mwu.mukogawa-u.ac.jp organization: Departments of Pharmaceutics and Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien, Kyuban-cho, Nishinomiya 663-8179, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16451747$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kEtv1DAUhS1URKeFJVvkFbsM9vUrWVYj2lJG7UhQHivLcW6YlCRO7YTSf0_aGdFdV3fznaNzvyNy0IceCXnL2ZID5x9uhmGp8iUsGWP6BVkAk5AZrvIDsmAMIBPKiENylNLNTBit9StyyLVU3EizINcnfmz-uLEJPQ013cBPGtHjMIZIsd-63mOi2-bXNutCi35qXaQ-dEOY-oq6MoU4PGbrGDoa3UibFqfuNXlZuzbhm_09JtenH7-uzrP11dmn1ck689IYk2kj0XNfcGRcF1DVChh3IjdgKiwLrqGsSuNrqQCdK6HIBdNVqQopsNBYiGPyftc7xHA7YRpt1ySPbet6DFOy2miQAGIGsx3oY0gpYm2H2HQu3lvO7INHO3u0KrdgHzzO_Lt98VR2WD3Re3EzADvgbn74_vk2e7E53-TKPK1o0oh__4dc_D0vFUbZ75dndvXj2-nn4ou0a_EPoU6PZA |
| CitedBy_id | crossref_primary_10_1002_wmts_74 crossref_primary_10_1152_ajpgi_00104_2019 crossref_primary_10_4049_jimmunol_180_4_2659 crossref_primary_10_1016_j_mce_2008_09_025 crossref_primary_10_1371_journal_pcbi_1011196 crossref_primary_10_1248_yakushi_131_1509 crossref_primary_10_1248_yakushi_16_00024 crossref_primary_10_1007_s11302_013_9397_9 crossref_primary_10_1152_physrev_00043_2006 crossref_primary_10_1248_yakushi_132_753 |
| Cites_doi | 10.1046/j.1440-1681.2003.03893.x 10.1211/0022357991772051 10.1111/j.1476-5381.1994.tb17125.x 10.1002/1097-0029(20001015)51:2<156::AID-JEMT7>3.0.CO;2-J 10.1016/0169-409X(89)90018-5 10.1002/1520-6017(200010)89:10<1296::AID-JPS7>3.0.CO;2-K 10.1016/S0006-291X(02)00272-3 10.1165/ajrcmb/4.4.295 10.1111/j.1476-5381.1988.tb11427.x 10.1152/ajpcell.1997.272.6.C1862 10.1021/js9504604 10.1016/S0165-6147(96)01035-8 10.1038/sj.bjp.0701329 10.1016/S0168-3659(99)00031-0 10.1016/0163-7258(94)00048-4 10.1016/0014-2999(92)90877-7 10.1271/bbb.65.743 10.2170/jjphysiol.50.235 10.1016/S0378-5173(98)00225-7 10.1111/j.2042-7158.1996.tb03937.x 10.1016/S0005-2736(03)00210-4 10.1016/0014-2999(86)90431-0 10.1021/js960529n 10.1211/0022357055524 10.1172/JCI113987 10.1111/j.1476-5381.1990.tb14087.x 10.1038/328275a0 10.1016/S0024-3205(98)00235-5 |
| ContentType | Journal Article |
| Copyright | 2006 Royal Pharmaceutical Society of Great Britain |
| Copyright_xml | – notice: 2006 Royal Pharmaceutical Society of Great Britain |
| DBID | BSCLL CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1211/jpp.58.2.0006 |
| DatabaseName | Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 2042-7158 |
| EndPage | 200 |
| ExternalDocumentID | 10_1211_jpp_58_2_0006 16451747 JPHP857 ark_67375_WNG_CXVFK9S4_L |
| Genre | article Journal Article |
| GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1CY 1OB 1OC 29L 31~ 33P 3O- 3SF 3WU 4.4 50Y 50Z 52M 52O 52S 52T 52U 52V 52W 53G 5GY 5RE 5WD 702 7PT 8-0 8-1 8-3 8-4 8-5 8WZ 930 A01 A03 A6W AABZA AACZT AAESR AAEVG AAHHS AAONW AAPGJ AAPXW AARHZ AAUAY AAVAP AAWDT AAYOK AAZKR ABCUV ABEJV ABJNI ABLJU ABNHQ ABOCM ABPQP ABPTD ABPVW ABQNK ABWST ABXVV ACBWZ ACCFJ ACFBH ACFRR ACGFO ACGFS ACIWK ACMXC ACPOU ACPRK ACUTJ ACXQS ACYHN ACZBC ADBBV ADEOM ADIPN ADIZJ ADKYN ADMGS ADQBN ADVEK ADXAS ADZMN AEEZP AEIMD AENEX AEQDE AEUQT AFBPY AFFNX AFFZL AFGKR AFPWT AFRAH AFXAL AFYAG AFZJQ AGMDO AGQXC AGUTN AHMBA AI. AIAGR AIURR AIWBW AJAOE AJBDE AJEEA ALAGY ALMA_UNASSIGNED_HOLDINGS AMBMR AMYDB APJGH AQDSO ASPBG ATGXG ATUGU AVNTJ AVWKF AZBYB AZFZN AZVAB BAFTC BCRHZ BDRZF BEYMZ BHBCM BROTX BRXPI BSCLL C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DRFUL DRMAN DRSTM DU5 EBS EJD EMOBN F00 F01 F04 F5P FECEO FEDTE FLUFQ FOEOM G-S G.N GODZA H.X H13 HF~ HVGLF HZ~ KBUDW KOP KSI KSN L7B LATKE LH4 LITHE LOXES LP6 LP7 LSO LUTES LW6 LYRES MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM MY~ N04 N05 NF~ NNB NOMLY O66 O9- OAUYM OCZFY OJZSN OPAEJ OVD OWPYF P2P P2W P2X P2Z P4D PALCI PQQKQ Q.N QB0 R.K RIWAO RJQFR ROL ROX RX1 SUPJJ TEORI TMA UB1 V8K VH1 W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WVDHM X7M XG1 YCJ ZGI ZXP ZZTAW ~IA ~WT AASNB CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c4777-674ec1c91e01692df5201a38727deb9162bdb7cf452eaab298306db5943e96e93 |
| ISSN | 0022-3573 |
| IngestDate | Fri Oct 25 23:45:25 EDT 2024 Fri Nov 22 01:56:11 EST 2024 Tue Oct 15 23:30:52 EDT 2024 Sat Aug 24 00:47:55 EDT 2024 Wed Oct 30 09:52:14 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c4777-674ec1c91e01692df5201a38727deb9162bdb7cf452eaab298306db5943e96e93 |
| Notes | istex:EAAF2AFD7FE1F9002319ECF34A462A57FA75F4F9 ArticleID:JPHP857 ark:/67375/WNG-CXVFK9S4-L ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://academic.oup.com/jpp/article-pdf/58/2/195/36735988/jpp.58.2.0006.pdf |
| PMID | 16451747 |
| PQID | 67624223 |
| PQPubID | 23479 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_67624223 crossref_primary_10_1211_jpp_58_2_0006 pubmed_primary_16451747 wiley_primary_10_1211_jpp_58_2_0006_JPHP857 istex_primary_ark_67375_WNG_CXVFK9S4_L |
| PublicationCentury | 2000 |
| PublicationDate | 2006-02 February 2006 2006-Feb 2006-02-01 20060201 |
| PublicationDateYYYYMMDD | 2006-02-01 |
| PublicationDate_xml | – month: 02 year: 2006 text: 2006-02 |
| PublicationDecade | 2000 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: England |
| PublicationTitle | Journal of pharmacy and pharmacology |
| PublicationTitleAlternate | J Pharm Pharmacol |
| PublicationYear | 2006 |
| Publisher | Blackwell Publishing Ltd |
| Publisher_xml | – name: Blackwell Publishing Ltd |
| References | Benham, C. D., Tsien, R. W. (1987) A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle. Nature 328: 275-278. Tomita, M., Hayashi, M., Awazu, S. (1996) Absorption-enhancing mechanism of EDTA, caprate and decanoylcarnitine in Caco-2 cells. J. Pharm. Sci. 85: 608-611. Barthe, L., Bessouet, M., Woodley, J. F., Houin, G. (1998) The improved everted gut sac: a simple method to study intestinal P-glycoprotein. Int. J. Pharm. 173: 255-258. Lindmark, T., Nikkila, T., Artursson, P. (1995) Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco-2 cell monolayers. J. Pharmacol. Exp. Ther. 275: 958-964. Lundy, P. M., Sawyer, T. W., Hand, B. T., Frew, R. (1998) Effect of bis-(2-chloroethyl)sulfide on AYP receptor-mediated responses of the rat vas deferens: possible relationship to cytotoxicity. J. Pharmacol. Exp. Ther. 285: 299-306. Ma, T. Y., Tran, D., Hoa, N., Nguyen, D., Merryfield, M., Tarnawski, A. (2000) Mechanism of extracellular calcium regulation of intestinal epithelial tight junction permeability: role of cytoskeletal involvement. Microsc. Res. Tech. 51: 156-168. Schwiebert, E. M., Zsembery, A. (2003) Extracellular ATP as a signaling molecule for epithelial cells. Biochim. Biophys. Acta. 1615: 7-32. Yamamoto, A., Uchiyama, T., Nishikawa, R., Fujita, T. (1996) Effectiveness and toxicity screening of various absorption enhancers in the rat small intestine: effects of absorption enhancers on the intestinal absorption of phenol red and the release of protein and phospholipids from the intestinal membrane. J. Pharm. Pharmacol. 48: 1285-1289. Kimura, T., Murakawa, Y., Ohno, M., Ohtani, S., Higaki, K. (1997) Gastrointestinal absorption of recombinant human insulin-like growth factor-I in rats. J. Pharmacol. Exp. Ther. 283: 611-618. Welford, L. A., Cusack, N. J., Hourani, S. M. (1986) ATP analogues and the guinea-pig taenia coli: a comparison of the structure-activity relationships of ectonucleotidases with those of the P2-purinoceptor. Eur. J. Pharmacol. 129: 217-224. Numata, N., Takahashi, K., Mizuno, N., Utoguchi, N., Watanabe, Y., Matsumoto, M., Mayumi, T. (2000) Improvement of intestinal absorption of macromolecules by nitric oxide donor. J. Pharm. Sci. 89: 1296-1304. Dubyak, G. R. (1991) Signal transduction by P2-purinergic receptors for extracellular ATP. Am. J. Respir. Cell Mol. Biol. 4: 295-300. Abbracchio, M. P., Burnstock, G. (1994) Purinoceptors: are there families of P2X and P2Y purinoceptors Pharmacol. Ther. 64: 445-475. Dunn, P. M., Blakeley, A. G. (1988) Suramin: a reversible P2-purinoceptor antagonist in the mouse vas deferens. Br. J. Pharmacol. 93: 243-245. Leipziger, J. (2003) Control of epithelial tranport via luminal P2 receptors. Am. J. Physiol. 284: F419-F432. Dezaki, K., Tsumura, T., Maeno, E., Okada, Y. (2000) Receptor-mediated facilitation of cell volume regulation by swelling-induced ATP release in human epithelial cells. Jpn J. Physiol. 50: 235-241. Tanaka, N., Kawasaki, K., Nejime, N., Kubota, Y., Takahashi, K., Hashimoto, M., Kunitomo, M., Shinozuka, K. (2003) P2Y receptor-mediated enhancement of permeation requires Ca2+ signaling in vascular endothelial cells. Clin. Exp. Pharmacol. Physiol. 30: 649-652. Lambrecht, G., Friebe, T., Grimm, U., Windscheif, U., Bungardt, E., Hildebrandt, C., Baumert, H. G., Spatz-Kumbel, G., Mutschler, E. (1992) PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. Eur. J. Pharmacol. 217: 217-219. Tanaka, N., Nejime, N., Kubota, Y., Kagota, S., Yudo, K., Nakamura, K., Kawasaki, K., Kunitomo, M., Takahashi, K., Hashimoto, M., Shinozuka, K. (2005) Myosin light chain kinase and Rho-kinase participate in P2Y receptor-mediated acceleration of permeability through the endothelial cell layer. J. Pharm. Pharmacol. 57: 335-340. Hayashi, M., Sakai, T., Hasegawa, Y., Nishikawahara, T., Tomioka, H., Iida, A., Shimizu, N., Tomita, M., Awazu, S. (1999) Physiological mechanism for enhancement of paracellular drug transport. J. Control. Release 62: 141-148. Shinozuka, K., Hashimoto, M., Masumura, S., Bjur, R. A., Westfall, D. P., Hattori, K. (1994) In vitro studies of release of adenine nucleotides and adenosine from rat vascular endothelium in response to alpha1-adrenoceptor stimulation. Br. J. Pharmacol. 113: 1203-1208. Inoue, C. N., Woo, J. S., Schwiebert, E. M., Morita, T., Hanaoka, K., Guggino, S. E., Guggino, W. B. (1997) Role of purinergic receptors in chloride secretion in Caco-2 cells. Am. J. Physiol. 272: C1862-C1870. Anderson, J. M., Van Itallie, C. M. (1995) Tight junctions and the molecular basis for regulation of paracellular permeability. Am. J. Physiol. 269: G467-G475. Sakai, M., Imai, T., Ohtake, H., Azuma, H., Otagiri, M. (1997) Effects of absorption enhancers on the transport of model compounds in Caco-2 cell monolayers: assessment by confocal laser scanning microscopy. J. Pharm. Sci. 86: 779-785. Katsuragi, T., Sato, C., Guangyuan, L., Honda, K. (2002) Inositol(1,4,5)trisphosphate signal triggers a receptor-mediated ATP release. Biochem. Biophys. Res. Commun. 293: 686-690. Sakai, M., Imai, T., Ohtake, H., Azuma, H., Otagiri, M. (1998) Effects of absorption enhancers on cytoskeletal actin filaments on Caco-2 cell monolayers. Life Sci. 63: 45-54. Sakai, M., Imai, T., Ohtake, H., Azuma, H., Otagiri, M. (1999) Simultaneous use of sodium deoxycholate and dipotassium glycyrrhizinate enhances the cellular transport of poorly absorbed compounds across Caco-2 cell monolayers. J. Pharm. Pharmacol. 51: 27-33. Fredholm, B. B., Abbracchio, M. P., Burnstock, G., Daly, J. W., Harden, T. K., Jacobson, K. A., Leff, P., Williams, M. (1994) Nomenclature and classification of purinoceptors. Pharmacol. Rev. 46: 143-156. Lindmark, T., Kimura, Y., Artursson, P. (1998) Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells. J. Pharmacol. Exp. Ther. 284: 362-369. Kimura, Y., Hosoda, Y., Yamaguchi, M., Nagano, H., Shima, M., Adachi, S., Matsuno, R. (2001) Effects of medium-chain fatty acids on intracellular calcium levels and the cytoskeleton in human intestinal (Caco-2) cell monolayers. Biosci. Biotechnol. Biochem. 65: 743-751. Matsuo, K., Katsuragi, T., Fujiki, S., Sato, C., Furukawa, T. (1997) ATP release and contraction mediated by different P2-receptor subtypes in guinea-pig ileal smooth muscle. Br. J. Pharmacol. 121: 1744-1748. Madara, J. L. (1989) Loosening tight junctions. Lessons from the intestine. J. Clin. Invest. 83: 1089-1094. Lee, V. H. L., Yamamoto, A. (1990) Penetration and enzymatic barriers to peptide and protein absorption. Adv. Drug Deliv. Rev. 4: 171-207. Communi, D., Boeynaems, J. M. (1997) Receptors responsive to extracellular pyrimidine nucleotides. Trends in Pharmacol. Sci. 18: 83-86. Bailey, S. J., Hourani, S. M. (1990) A study of the purinoceptors mediating contraction in the rat colon. Br. J. Pharmacol. 100: 753-756. Ralevic, V., Burnstock, G. (1998) Receptors for purines and pyrimidines. Pharmacol. Rev. 50: 413-492. 1991; 4 1994; 113 1989; 83 2003; 1615 2002; 293 1997; 272 2000; 89 1997; 86 1987; 328 2000; 50 2000; 51 1994; 46 1999; 62 1995; 275 1998; 63 1990; 100 1988; 93 2003; 30 1998; 173 1994; 64 2001; 65 1986; 129 1997; 283 1997; 121 1997; 18 1992; 217 1996; 85 1995; 269 1998; 50 1999; 51 1996; 48 1998; 285 2005; 57 1990; 4 2003; 284 1998; 284 Bailey (2024103109334546200_cit3) 1990; 100 Yamamoto (2024103109334546200_cit36) 1996; 48 Katsuragi (2024103109334546200_cit13) 2002; 293 Fredholm (2024103109334546200_cit10) 1994; 46 Lundy (2024103109334546200_cit21) 1998; 285 Communi (2024103109334546200_cit6) 1997; 18 Sakai (2024103109334546200_cit28) 1998; 63 Lindmark (2024103109334546200_cit20) 1998; 284 Kimura (2024103109334546200_cit14) 1997; 283 Shinozuka (2024103109334546200_cit31) 1994; 113 Leipziger (2024103109334546200_cit18) 2003; 284 Lindmark (2024103109334546200_cit19) 1995; 275 Lee (2024103109334546200_cit17) 1990; 4 Inoue (2024103109334546200_cit12) 1997; 272 Lambrecht (2024103109334546200_cit16) 1992; 217 Tomita (2024103109334546200_cit34) 1996; 85 Hayashi (2024103109334546200_cit11) 1999; 62 Anderson (2024103109334546200_cit2) 1995; 269 Benham (2024103109334546200_cit5) 1987; 328 Ralevic (2024103109334546200_cit26) 1998; 50 Kimura (2024103109334546200_cit15) 2001; 65 Dubyak (2024103109334546200_cit8) 1991; 4 Madara (2024103109334546200_cit23) 1989; 83 Matsuo (2024103109334546200_cit24) 1997; 121 Abbracchio (2024103109334546200_cit1) 1994; 64 Tanaka (2024103109334546200_cit32) 2003; 30 Numata (2024103109334546200_cit25) 2000; 89 Sakai (2024103109334546200_cit27) 1997; 86 Schwiebert (2024103109334546200_cit30) 2003; 1615 Dunn (2024103109334546200_cit9) 1988; 93 Barthe (2024103109334546200_cit4) 1998; 173 Ma (2024103109334546200_cit22) 2000; 51 Dezaki (2024103109334546200_cit7) 2000; 50 Tanaka (2024103109334546200_cit33) 2005; 57 Welford (2024103109334546200_cit35) 1986; 129 Sakai (2024103109334546200_cit29) 1999; 51 |
| References_xml | – volume: 283 start-page: 611 year: 1997 end-page: 618 article-title: Gastrointestinal absorption of recombinant human insulin‐like growth factor‐I in rats publication-title: J. Pharmacol. Exp. Ther. – volume: 64 start-page: 445 year: 1994 end-page: 475 article-title: Purinoceptors: are there families of P2X and P2Y purinoceptors publication-title: Pharmacol. Ther. – volume: 63 start-page: 45 year: 1998 end-page: 54 article-title: Effects of absorption enhancers on cytoskeletal actin filaments on Caco‐2 cell monolayers publication-title: Life Sci. – volume: 65 start-page: 743 year: 2001 end-page: 751 article-title: Effects of medium‐chain fatty acids on intracellular calcium levels and the cytoskeleton in human intestinal (Caco‐2) cell monolayers publication-title: Biosci. Biotechnol. Biochem. – volume: 1615 start-page: 7 year: 2003 end-page: 32 article-title: Extracellular ATP as a signaling molecule for epithelial cells publication-title: Biochim. Biophys. Acta. – volume: 51 start-page: 27 year: 1999 end-page: 33 article-title: Simultaneous use of sodium deoxycholate and dipotassium glycyrrhizinate enhances the cellular transport of poorly absorbed compounds across Caco‐2 cell monolayers publication-title: J. Pharm. Pharmacol. – volume: 85 start-page: 608 year: 1996 end-page: 611 article-title: Absorption‐enhancing mechanism of EDTA, caprate and decanoylcarnitine in Caco‐2 cells publication-title: J. Pharm. Sci. – volume: 57 start-page: 335 year: 2005 end-page: 340 article-title: Myosin light chain kinase and Rho‐kinase participate in P2Y receptor‐mediated acceleration of permeability through the endothelial cell layer publication-title: J. Pharm. Pharmacol. – volume: 48 start-page: 1285 year: 1996 end-page: 1289 article-title: Effectiveness and toxicity screening of various absorption enhancers in the rat small intestine: effects of absorption enhancers on the intestinal absorption of phenol red and the release of protein and phospholipids from the intestinal membrane publication-title: J. Pharm. Pharmacol. – volume: 18 start-page: 83 year: 1997 end-page: 86 article-title: Receptors responsive to extracellular pyrimidine nucleotides publication-title: Trends in Pharmacol. Sci. – volume: 50 start-page: 413 year: 1998 end-page: 492 article-title: Receptors for purines and pyrimidines publication-title: Pharmacol. Rev. – volume: 285 start-page: 299 year: 1998 end-page: 306 article-title: Effect of bis‐(2‐chloroethyl)sulfide on AYP receptor‐mediated responses of the rat vas deferens: possible relationship to cytotoxicity publication-title: J. Pharmacol. Exp. Ther. – volume: 4 start-page: 295 year: 1991 end-page: 300 article-title: Signal transduction by P2‐purinergic receptors for extracellular ATP publication-title: Am. J. Respir. Cell Mol. Biol. – volume: 51 start-page: 156 year: 2000 end-page: 168 article-title: Mechanism of extracellular calcium regulation of intestinal epithelial tight junction permeability: role of cytoskeletal involvement publication-title: Microsc. Res. Tech. – volume: 113 start-page: 1203 year: 1994 end-page: 1208 article-title: In vitro studies of release of adenine nucleotides and adenosine from rat vascular endothelium in response to alpha1‐adrenoceptor stimulation publication-title: Br. J. Pharmacol. – volume: 173 start-page: 255 year: 1998 end-page: 258 article-title: The improved everted gut sac: a simple method to study intestinal P‐glycoprotein publication-title: Int. J. Pharm. – volume: 62 start-page: 141 year: 1999 end-page: 148 article-title: Physiological mechanism for enhancement of paracellular drug transport publication-title: J. Control. Release – volume: 217 start-page: 217 year: 1992 end-page: 219 article-title: PPADS, a novel functionally selective antagonist of P2 purinoceptor‐mediated responses publication-title: Eur. J. Pharmacol. – volume: 272 start-page: C1862 year: 1997 end-page: C1870 article-title: Role of purinergic receptors in chloride secretion in Caco‐2 cells publication-title: Am. J. Physiol. – volume: 284 start-page: 362 year: 1998 end-page: 369 article-title: Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco‐2 cells publication-title: J. Pharmacol. Exp. Ther. – volume: 328 start-page: 275 year: 1987 end-page: 278 article-title: A novel receptor‐operated Ca ‐permeable channel activated by ATP in smooth muscle publication-title: Nature – volume: 100 start-page: 753 year: 1990 end-page: 756 article-title: A study of the purinoceptors mediating contraction in the rat colon publication-title: Br. J. Pharmacol. – volume: 275 start-page: 958 year: 1995 end-page: 964 article-title: Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco‐2 cell monolayers publication-title: J. Pharmacol. Exp. Ther. – volume: 83 start-page: 1089 year: 1989 end-page: 1094 article-title: Loosening tight junctions. Lessons from the intestine publication-title: J. Clin. Invest. – volume: 293 start-page: 686 year: 2002 end-page: 690 article-title: Inositol(1,4,5)trisphosphate signal triggers a receptor‐mediated ATP release publication-title: Biochem. Biophys. Res. Commun. – volume: 89 start-page: 1296 year: 2000 end-page: 1304 article-title: Improvement of intestinal absorption of macromolecules by nitric oxide donor publication-title: J. Pharm. Sci. – volume: 129 start-page: 217 year: 1986 end-page: 224 article-title: ATP analogues and the guinea‐pig taenia coli: a comparison of the structure‐activity relationships of ectonucleotidases with those of the P2‐purinoceptor publication-title: Eur. J. Pharmacol. – volume: 284 start-page: F419 year: 2003 end-page: F432 article-title: Control of epithelial tranport via luminal P2 receptors publication-title: Am. J. Physiol. – volume: 46 start-page: 143 year: 1994 end-page: 156 article-title: Nomenclature and classification of purinoceptors publication-title: Pharmacol. Rev. – volume: 4 start-page: 171 year: 1990 end-page: 207 article-title: Penetration and enzymatic barriers to peptide and protein absorption publication-title: Adv. Drug Deliv. Rev. – volume: 50 start-page: 235 year: 2000 end-page: 241 article-title: Receptor‐mediated facilitation of cell volume regulation by swelling‐induced ATP release in human epithelial cells publication-title: Jpn J. Physiol. – volume: 269 start-page: G467 year: 1995 end-page: G475 article-title: Tight junctions and the molecular basis for regulation of paracellular permeability publication-title: Am. J. Physiol. – volume: 93 start-page: 243 year: 1988 end-page: 245 article-title: Suramin: a reversible P2‐purinoceptor antagonist in the mouse vas deferens publication-title: Br. J. Pharmacol. – volume: 86 start-page: 779 year: 1997 end-page: 785 article-title: Effects of absorption enhancers on the transport of model compounds in Caco‐2 cell monolayers: assessment by confocal laser scanning microscopy publication-title: J. Pharm. Sci. – volume: 30 start-page: 649 year: 2003 end-page: 652 article-title: P2Y receptor‐mediated enhancement of permeation requires Ca signaling in vascular endothelial cells publication-title: Clin. Exp. Pharmacol. Physiol. – volume: 121 start-page: 1744 year: 1997 end-page: 1748 article-title: ATP release and contraction mediated by different P2‐receptor subtypes in guinea‐pig ileal smooth muscle publication-title: Br. J. Pharmacol. – volume: 30 start-page: 649 year: 2003 ident: 2024103109334546200_cit32 article-title: P2Y receptor-mediated enhancement of permeation requires Ca2+ signaling in vascular endothelial cells publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1046/j.1440-1681.2003.03893.x contributor: fullname: Tanaka – volume: 46 start-page: 143 year: 1994 ident: 2024103109334546200_cit10 article-title: Nomenclature and classification of purinoceptors publication-title: Pharmacol. Rev. contributor: fullname: Fredholm – volume: 51 start-page: 27 year: 1999 ident: 2024103109334546200_cit29 article-title: Simultaneous use of sodium deoxycholate and dipotassium glycyrrhizinate enhances the cellular transport of poorly absorbed compounds across Caco-2 cell monolayers publication-title: J. Pharm. Pharmacol. doi: 10.1211/0022357991772051 contributor: fullname: Sakai – volume: 113 start-page: 1203 year: 1994 ident: 2024103109334546200_cit31 article-title: In vitro studies of release of adenine nucleotides and adenosine from rat vascular endothelium in response to alpha1-adrenoceptor stimulation publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.1994.tb17125.x contributor: fullname: Shinozuka – volume: 51 start-page: 156 year: 2000 ident: 2024103109334546200_cit22 article-title: Mechanism of extracellular calcium regulation of intestinal epithelial tight junction permeability: role of cytoskeletal involvement publication-title: Microsc. Res. Tech. doi: 10.1002/1097-0029(20001015)51:2<156::AID-JEMT7>3.0.CO;2-J contributor: fullname: Ma – volume: 4 start-page: 171 year: 1990 ident: 2024103109334546200_cit17 article-title: Penetration and enzymatic barriers to peptide and protein absorption publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/0169-409X(89)90018-5 contributor: fullname: Lee – volume: 89 start-page: 1296 year: 2000 ident: 2024103109334546200_cit25 article-title: Improvement of intestinal absorption of macromolecules by nitric oxide donor publication-title: J. Pharm. Sci. doi: 10.1002/1520-6017(200010)89:10<1296::AID-JPS7>3.0.CO;2-K contributor: fullname: Numata – volume: 293 start-page: 686 year: 2002 ident: 2024103109334546200_cit13 article-title: Inositol(1,4,5)trisphosphate signal triggers a receptor-mediated ATP release publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/S0006-291X(02)00272-3 contributor: fullname: Katsuragi – volume: 4 start-page: 295 year: 1991 ident: 2024103109334546200_cit8 article-title: Signal transduction by P2-purinergic receptors for extracellular ATP publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/ajrcmb/4.4.295 contributor: fullname: Dubyak – volume: 93 start-page: 243 year: 1988 ident: 2024103109334546200_cit9 article-title: Suramin: a reversible P2-purinoceptor antagonist in the mouse vas deferens publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.1988.tb11427.x contributor: fullname: Dunn – volume: 272 start-page: C1862 year: 1997 ident: 2024103109334546200_cit12 article-title: Role of purinergic receptors in chloride secretion in Caco-2 cells publication-title: Am. J. Physiol. doi: 10.1152/ajpcell.1997.272.6.C1862 contributor: fullname: Inoue – volume: 85 start-page: 608 year: 1996 ident: 2024103109334546200_cit34 article-title: Absorption-enhancing mechanism of EDTA, caprate and decanoylcarnitine in Caco-2 cells publication-title: J. Pharm. Sci. doi: 10.1021/js9504604 contributor: fullname: Tomita – volume: 18 start-page: 83 year: 1997 ident: 2024103109334546200_cit6 article-title: Receptors responsive to extracellular pyrimidine nucleotides publication-title: Trends in Pharmacol. Sci. doi: 10.1016/S0165-6147(96)01035-8 contributor: fullname: Communi – volume: 284 start-page: 362 year: 1998 ident: 2024103109334546200_cit20 article-title: Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Lindmark – volume: 121 start-page: 1744 year: 1997 ident: 2024103109334546200_cit24 article-title: ATP release and contraction mediated by different P2-receptor subtypes in guinea-pig ileal smooth muscle publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0701329 contributor: fullname: Matsuo – volume: 62 start-page: 141 year: 1999 ident: 2024103109334546200_cit11 article-title: Physiological mechanism for enhancement of paracellular drug transport publication-title: J. Control. Release doi: 10.1016/S0168-3659(99)00031-0 contributor: fullname: Hayashi – volume: 64 start-page: 445 year: 1994 ident: 2024103109334546200_cit1 article-title: Purinoceptors: are there families of P2X and P2Y purinoceptors publication-title: Pharmacol. Ther. doi: 10.1016/0163-7258(94)00048-4 contributor: fullname: Abbracchio – volume: 217 start-page: 217 year: 1992 ident: 2024103109334546200_cit16 article-title: PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses publication-title: Eur. J. Pharmacol. doi: 10.1016/0014-2999(92)90877-7 contributor: fullname: Lambrecht – volume: 269 start-page: G467 year: 1995 ident: 2024103109334546200_cit2 article-title: Tight junctions and the molecular basis for regulation of paracellular permeability publication-title: Am. J. Physiol. contributor: fullname: Anderson – volume: 65 start-page: 743 year: 2001 ident: 2024103109334546200_cit15 article-title: Effects of medium-chain fatty acids on intracellular calcium levels and the cytoskeleton in human intestinal (Caco-2) cell monolayers publication-title: Biosci. Biotechnol. Biochem. doi: 10.1271/bbb.65.743 contributor: fullname: Kimura – volume: 284 start-page: F419 year: 2003 ident: 2024103109334546200_cit18 article-title: Control of epithelial tranport via luminal P2 receptors publication-title: Am. J. Physiol. contributor: fullname: Leipziger – volume: 50 start-page: 413 year: 1998 ident: 2024103109334546200_cit26 article-title: Receptors for purines and pyrimidines publication-title: Pharmacol. Rev. contributor: fullname: Ralevic – volume: 275 start-page: 958 year: 1995 ident: 2024103109334546200_cit19 article-title: Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco-2 cell monolayers publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Lindmark – volume: 50 start-page: 235 year: 2000 ident: 2024103109334546200_cit7 article-title: Receptor-mediated facilitation of cell volume regulation by swelling-induced ATP release in human epithelial cells publication-title: Jpn J. Physiol. doi: 10.2170/jjphysiol.50.235 contributor: fullname: Dezaki – volume: 285 start-page: 299 year: 1998 ident: 2024103109334546200_cit21 article-title: Effect of bis-(2-chloroethyl)sulfide on AYP receptor-mediated responses of the rat vas deferens: possible relationship to cytotoxicity publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Lundy – volume: 173 start-page: 255 year: 1998 ident: 2024103109334546200_cit4 article-title: The improved everted gut sac: a simple method to study intestinal P-glycoprotein publication-title: Int. J. Pharm. doi: 10.1016/S0378-5173(98)00225-7 contributor: fullname: Barthe – volume: 48 start-page: 1285 year: 1996 ident: 2024103109334546200_cit36 article-title: Effectiveness and toxicity screening of various absorption enhancers in the rat small intestine: effects of absorption enhancers on the intestinal absorption of phenol red and the release of protein and phospholipids from the intestinal membrane publication-title: J. Pharm. Pharmacol. doi: 10.1111/j.2042-7158.1996.tb03937.x contributor: fullname: Yamamoto – volume: 1615 start-page: 7 year: 2003 ident: 2024103109334546200_cit30 article-title: Extracellular ATP as a signaling molecule for epithelial cells publication-title: Biochim. Biophys. Acta. doi: 10.1016/S0005-2736(03)00210-4 contributor: fullname: Schwiebert – volume: 283 start-page: 611 year: 1997 ident: 2024103109334546200_cit14 article-title: Gastrointestinal absorption of recombinant human insulin-like growth factor-I in rats publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Kimura – volume: 129 start-page: 217 year: 1986 ident: 2024103109334546200_cit35 article-title: ATP analogues and the guinea-pig taenia coli: a comparison of the structure-activity relationships of ectonucleotidases with those of the P2-purinoceptor publication-title: Eur. J. Pharmacol. doi: 10.1016/0014-2999(86)90431-0 contributor: fullname: Welford – volume: 86 start-page: 779 year: 1997 ident: 2024103109334546200_cit27 article-title: Effects of absorption enhancers on the transport of model compounds in Caco-2 cell monolayers: assessment by confocal laser scanning microscopy publication-title: J. Pharm. Sci. doi: 10.1021/js960529n contributor: fullname: Sakai – volume: 57 start-page: 335 year: 2005 ident: 2024103109334546200_cit33 article-title: Myosin light chain kinase and Rho-kinase participate in P2Y receptor-mediated acceleration of permeability through the endothelial cell layer publication-title: J. Pharm. Pharmacol. doi: 10.1211/0022357055524 contributor: fullname: Tanaka – volume: 83 start-page: 1089 year: 1989 ident: 2024103109334546200_cit23 article-title: Loosening tight junctions. Lessons from the intestine publication-title: J. Clin. Invest. doi: 10.1172/JCI113987 contributor: fullname: Madara – volume: 100 start-page: 753 year: 1990 ident: 2024103109334546200_cit3 article-title: A study of the purinoceptors mediating contraction in the rat colon publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.1990.tb14087.x contributor: fullname: Bailey – volume: 328 start-page: 275 year: 1987 ident: 2024103109334546200_cit5 article-title: A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle publication-title: Nature doi: 10.1038/328275a0 contributor: fullname: Benham – volume: 63 start-page: 45 year: 1998 ident: 2024103109334546200_cit28 article-title: Effects of absorption enhancers on cytoskeletal actin filaments on Caco-2 cell monolayers publication-title: Life Sci. doi: 10.1016/S0024-3205(98)00235-5 contributor: fullname: Sakai |
| SSID | ssj0007666 |
| Score | 1.8431103 |
| Snippet | While there are no reports concerning the effects of extracellular nucleotides on the intestinal absorption of drugs, it is well known that extracellular... |
| SourceID | proquest crossref pubmed wiley istex |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 195 |
| SubjectTerms | Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Animals Dextrans - blood Dextrans - pharmacokinetics Fluorescein-5-isothiocyanate - analogs & derivatives Fluorescein-5-isothiocyanate - pharmacokinetics Ileum - drug effects Ileum - metabolism Intestinal Absorption - drug effects Male Nucleotides - pharmacology Purinergic P2 Receptor Agonists Purinergic P2 Receptor Antagonists Pyridoxal Phosphate - analogs & derivatives Pyridoxal Phosphate - pharmacology Rats Rats, Wistar Receptors, Purinergic P2 - metabolism Suramin - pharmacology Thionucleotides - pharmacology |
| Title | Activation of P2Y receptor enhances high-molecular compound absorption from rat ileum |
| URI | https://api.istex.fr/ark:/67375/WNG-CXVFK9S4-L/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1211%2Fjpp.58.2.0006 https://www.ncbi.nlm.nih.gov/pubmed/16451747 https://search.proquest.com/docview/67624223 |
| Volume | 58 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtpAEF6RcOml6n9J03YPFRfHyCxer32kKSlqKoQEJfRk-WctEMK2MEhRTn2EPmOfpLO7theSKGoOvVhoGQzsfJ6d2Z35BqFP1BJU2bFncnFIaDOHmp4VeaYVEs8KHMdKZIXccMJGc_fLwB40GhXvrR77r5qGMdC1qJx9hLbrm8IAvAadwxW0Dtd_0ns_qhqWyfQ28tMAm8bzrWD2ThdCx4UhOIrrLId11SBXppeLLktGEBbZRtkSWX4CKDHAepSsDXdd2VzxXysqp1yTYdfb9ZfLNCsWS-WpjoItTMhS7xmsRFmZbC5sTLN1tsr0W7H8xGSxNzhZwM1udquylu1mtw6K4PbmxUEiyK1NSrXpptOZdLWBanfS4XKMiJIi1lWU75UVp-4eWsmeSe6qJp7l6q54Ue8uHEQtHHneoW5HcrjeQ9BdC9IHRaV38G08HLuUHaEmARMIFrjZ_zyfzWovgTnqHL36fyX_KxFZZvu3PvCXmuLRv74vGDqMraRzNH2GnpZQwH0Fx-eowdMXqD0uYXGGp7rKrzjDbTzew8hLdKUxi7MEA2ZxhVlcYRYLzP759btGK67QijVasUArBrRiidZX6MfFYHo-NMuGH2ZkM8ZMh9k86kZelwuOIBInFNzToOeCjx3zEAIZEsYhixKbEh4EYE1cCHjjkHp2j3sO93qv0XGapfwtwg7lVmLHdhLYELR4oRsRkGBeHDq9bsRJC7WrafVzxevii3iYiHg4z33q-kQkZjggKCe9lgo2K5EMyah_Nfrqn89nF5fexPa_t9DHSis-mGhx7hakPNsVIC2KsEivhd4oZelvdGzBFM9ayJDae_in-CWmTh4l_Q490U_eKTrebnb8PToq4t2HEpN_Aez4yX8 |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | Oxford University Press |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Activation+of+P2Y+receptor+enhances+high%E2%80%90molecular+compound+absorption+from+rat+ileum&rft.jtitle=Journal+of+pharmacy+and+pharmacology&rft.au=Kinoshita%2C+Natsumi&rft.au=Takahashi%2C+Tomoko&rft.au=Tada%2C+Shoko&rft.au=Shinozuka%2C+Kazumasa&rft.date=2006-02-01&rft.pub=Blackwell+Publishing+Ltd&rft.issn=0022-3573&rft.eissn=2042-7158&rft.volume=58&rft.issue=2&rft.spage=195&rft.epage=200&rft_id=info:doi/10.1211%2Fjpp.58.2.0006&rft.externalDBID=10.1211%252Fjpp.58.2.0006&rft.externalDocID=JPHP857 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3573&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3573&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3573&client=summon |