Contrasting effects of single doses of pindolol and xamoterol on left ventricular diastolic function

Impaired left ventricular diastolic dysfunction is common in patients with ischaemic heart failure. The beta 1‐adrenoceptor partial agonist xamoterol was compared with pindolol, a beta‐adrenoceptor blocker with intrinsic sympathomimetic activity, in a haemodynamic study in 17 patients with ischaemic...

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Bibliographic Details
Published in:	British journal of clinical pharmacology Vol. 28; no. S1; pp. 84S - 85S
Main Authors:	Rousseau, MF, Pouleur, H, Debaisieux, JC, Eyll, C, Charlier, AA
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-01-1989
Subjects:	Adrenergic beta-Agonists - pharmacology Blood Pressure - drug effects Coronary Disease - physiopathology Diastole Female Heart - drug effects Heart Rate - drug effects Humans Male Pindolol - pharmacology Propanolamines - pharmacology Xamoterol
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Summary:	Impaired left ventricular diastolic dysfunction is common in patients with ischaemic heart failure. The beta 1‐adrenoceptor partial agonist xamoterol was compared with pindolol, a beta‐adrenoceptor blocker with intrinsic sympathomimetic activity, in a haemodynamic study in 17 patients with ischaemic heart disease. Pindolol caused left ventricular end‐diastolic pressure, wall stress and T1 to rise, whereas xamoterol produced improvements in all three parameters. These results suggest that xamoterol may be of greater benefit to patients in heart failure.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-5251 1365-2125
DOI:	10.1111/j.1365-2125.1989.tb03582.x