A Component-Based FPGA Design Framework for Neuronal Ion Channel Dynamics Simulations

• Published in: IEEE transactions on neural systems and rehabilitation engineering Vol. 14; no. 4; pp. 410 - 418
• Main Authors: Mak, Terrence S. T., Rachmuth, Guy, Lam, Kai-Pui, Poon, Chi-Sang
• Format: Journal Article
• Language: English
• Published: United States IEEE 01-12-2006
• Subjects: Action Potentials - physiology; Brain modeling; Brain-machine interface; Clamps; Computational modeling; Computer applications; Computer Simulation; Concurrent computing; Delay; dynamic clamp; Equipment Design; Equipment Failure Analysis; Field programmable gate arrays; field-programmable gate array (FPGA); Ion Channel Gating - physiology; Logic design; Logistic Models; Membrane Potentials - physiology; Models, Neurological; Neural prosthesis; neuronal ion channel; Neurons - physiology; neuroprosthetic device; Parallel processing; Receptors, AMPA - metabolism; Receptors, N-Methyl-D-Aspartate - metabolism; Signal Processing, Computer-Assisted - instrumentation; Synaptic Transmission - physiology
• ISSN: 1534-4320
• DOI: 10.1109/TNSRE.2006.886727

Neuron-machine interfaces such as dynamic clamp and brain-implantable neuroprosthetic devices require real-time simulations of neuronal ion channel dynamics. Field-programmable gate array (FPGA) has emerged as a high-speed digital platform ideal for such application-specific computations. We propose an efficient and flexible component-based FPGA design framework for neuronal ion channel dynamics simulations, which overcomes certain limitations of the recently proposed memory-based approach. A parallel processing strategy is used to minimize computational delay, and a hardware-efficient factoring approach for calculating exponential and division functions in neuronal ion channel models is used to conserve resource consumption. Performances of the various FPGA design approaches are compared theoretically and experimentally in corresponding implementations of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) synaptic ion channel models. Our results suggest that the component-based design framework provides a more memory economic solution, as well as more efficient logic utilization for large word lengths, whereas the memory-based approach may be suitable for time-critical applications where a higher throughput rate is desired