Five-aza-2′-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells

DNA methyltransferase inhibitors (DNMT inhibitors) are administered for high-risk MDS, but their action mechanisms are not fully understood. Hence, we performed a genome-wide DNA methylation assay and focused on cholesterol 25-hydroxylase ( CH25H ) among the genes whose expression was up-regulated a...

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Bibliographic Details
Published in:	Scientific reports Vol. 5; no. 1; p. 16709
Main Authors:	Tsujioka, Takayuki, Yokoi, Akira, Itano, Yoshitaro, Takahashi, Kentaro, Ouchida, Mamoru, Okamoto, Shuichiro, Kondo, Toshinori, Suemori, Shin-ichiro, Tohyama, Yumi, Tohyama, Kaoru
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18-11-2015 Nature Publishing Group
Subjects:	38 38/109 38/39 38/43 38/77 631/80/82/23 692/308/575 Antimetabolites, Antineoplastic - pharmacology Azacitidine - analogs & derivatives Azacitidine - pharmacology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Cell Death - drug effects Cell Death - genetics Cell Line, Tumor Cell Proliferation - drug effects Decitabine DNA Methylation - drug effects Epigenesis, Genetic - drug effects Gene Expression Profiling Gene Expression Regulation, Leukemic - drug effects Gene Knockout Techniques HL-60 Cells Humanities and Social Sciences Humans Leukemia - genetics Leukemia - metabolism multidisciplinary Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - metabolism Promoter Regions, Genetic RNA, Small Interfering - genetics Science Signal Transduction Steroid Hydroxylases - genetics Steroid Hydroxylases - metabolism Transcriptome
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