Role of endothelium in shear stress-induced constrictions in rat middle cerebral artery

Luminal shear stress has been reported to constrict cerebral arteries and arterioles of several species. Although the endothelium is not required for this response, it is not known whether the endothelium enhances or attenuates shear stress-induced constrictions. Middle cerebral arteries (MCAs) were...

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Bibliographic Details
Published in:	Stroke (1970) Vol. 32; no. 6; pp. 1394 - 1400
Main Authors:	BRYAN, Robert M, STEENBERG, Marie L, MARRELLI, Sean P
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 01-06-2001 American Heart Association, Inc
Subjects:	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt - pharmacology Animals Antioxidants - pharmacology Biological and medical sciences Blood Flow Velocity - physiology Calcium - metabolism Catalase - pharmacology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Charybdotoxin - pharmacology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enzyme Inhibitors - pharmacology Fluorescent Dyes Free Radical Scavengers - pharmacology Fundamental and applied biological sciences. Psychology Fura-2 In Vitro Techniques Male Middle Cerebral Artery - cytology Middle Cerebral Artery - drug effects Middle Cerebral Artery - physiology NG-Nitroarginine Methyl Ester - pharmacology Rats Rats, Long-Evans Reactive Oxygen Species - metabolism Stress, Mechanical Superoxide Dismutase - pharmacology Vasoconstriction - drug effects Vasoconstriction - physiology Vertebrates: nervous system and sense organs Rat Rodentia Central nervous system Middle cerebral artery Vasoconstriction Exploration Free radical Endothelium Vertebrata Mammalia Calcium ion Blood vessel Animal Shear stress Circulatory system Hemodynamics Brain (vertebrata)
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