Design and Synthesis of New Anthranyl Phenylhydrazides: Antileishmanial Activity and Structure–Activity Relationship

Leishmaniasis is a neglected tropical disease affecting millions of people worldwide. A centenary approach to antimonial-based drugs was first initiated with the synthesis of urea stibamine by Upendranath Brahmachari in 1922. The need for new drug development led to resistance toward antimoniates. N...

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Bibliographic Details
Published in:	Pharmaceuticals (Basel, Switzerland) Vol. 16; no. 8; p. 1120
Main Authors:	do Carmo Maquiaveli, Claudia, da Silva, Edson Roberto, Hild de Jesus, Barbara, Oliveira Monteiro, Caio Eduardo, Rodrigues Navarro, Tiago, Pereira Branco, Luiz Octavio, Souza dos Santos, Isabela, Figueiredo Reis, Nanashara, Portugal, Arieli Bernardo, Mendes Wanderley, João Luiz, Borges Farias, André, Correia Romeiro, Nelilma, de Lima, Evanoel Crizanto
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 01-08-2023 MDPI
Subjects:	ABC transporters Analysis anthranyl hydrazides arginase Biosynthesis Design Drug therapy Drugs Enzymes Leishmania Leishmaniasis Parasitic diseases Polyamines PTR1 Structure-activity relationship (Pharmacology) Structure-activity relationships Toxicity Tropical diseases Brazil
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