Increased miR‐223 expression in T cells from patients with rheumatoid arthritis leads to decreased insulin‐like growth factor‐1‐mediated interleukin‐10 production

Summary We hypothesized that the aberrant expression of microRNAs (miRNAs) in rheumatoid arthritis (RA) T cells was involved in the pathogenesis of RA. The expression profile of 270 human miRNAs in T cells from the first five RA patients and five controls were analysed by real‐time polymerase chain...

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Bibliographic Details
Published in:	Clinical and experimental immunology Vol. 177; no. 3; pp. 641 - 651
Main Authors:	Lu, M.‐C., Yu, C.‐L., Chen, H.‐C., Yu, H.‐C., Huang, H.‐B., Lai, N.‐S.
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01-09-2014 Blackwell Science Inc
Subjects:	Adult Aged Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - metabolism Case-Control Studies CD28 Antigens - immunology CD3 Complex - immunology Cell Line Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Cytokines Female Gene Expression Gene Expression Profiling Gene Expression Regulation Genes Humans Insulin-Like Growth Factor I - metabolism Insulin-like growth factors insulin‐like growth factor‐1 receptor interleukin 10 Interleukin-10 - biosynthesis Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lymphocytes Male MicroRNAs - genetics Middle Aged miR‐223 Original Protein expression Proteins Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism Rheumatoid arthritis RNA Interference T cells T-Lymphocytes - drug effects T-Lymphocytes - metabolism Transfection miR-223 insulin-like growth factor-1 receptor T cells rheumatoid arthritis interleukin 10
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