Subcutaneous adipose tissue sclerostin is reduced and Wnt signaling is enhanced following 4‐weeks of sprint interval training in young men with obesity
Sclerostin is a Wnt/β‐catenin antagonist, mainly secreted by osteocytes, and most known for its role in reducing bone formation. Studies in rodents suggest sclerostin can also regulate adipose tissue mass and metabolism, representing bone–adipose tissue crosstalk. Exercise training has been shown to...
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| Published in: | Physiological reports Vol. 10; no. 6; pp. e15232 - n/a |
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| Abstract | Sclerostin is a Wnt/β‐catenin antagonist, mainly secreted by osteocytes, and most known for its role in reducing bone formation. Studies in rodents suggest sclerostin can also regulate adipose tissue mass and metabolism, representing bone–adipose tissue crosstalk. Exercise training has been shown to reduce plasma sclerostin levels; but the effects of exercise on sclerostin and Wnt/β‐catenin signaling specifically within adipose tissue has yet to be examined. The purpose of this study was to examine subcutaneous WAT (scWAT) sclerostin content and Wnt signaling in response to exercise training in young men with obesity. To this end, 7 male participants (BMI = 35 ± 4; 25 ± 4 years) underwent 4 weeks of sprint interval training (SIT) involving 4 weekly sessions consisting of a 5‐min warmup, followed by 8 × 20 s intervals at 170% of work rate at VO2peak, separated by 10 s of rest. Serum and scWAT were sampled at rest both pre‐ and post‐SIT. Despite no changes in serum sclerostin levels, we found a significant decrease in adipose sclerostin content (−37%, p = 0.04), an increase in total β‐catenin (+52%, p = 0.03), and no changes in GSK3β serine 9 phosphorylation. There were also concomitant reductions in serum TNF‐α (−0.36 pg/ml, p = 0.03) and IL‐6 (−1.44 pg/ml, p = 0.05) as well as an increase in VO2peak (+5%, p = 0.03) and scWAT COXIV protein content (+95%, p = 0.04). In conclusion, scWAT sclerostin content was reduced and β‐catenin content was increased following SIT in young men with excess adiposity, suggesting a role of sclerostin in regulating human adipose tissue in response to exercise training.
In this study, we examined sclerostin content in serum and subcutaneous adipose tissue both pre‐ and post‐exercise training in humans with obesity. Our data support that sclerostin decreases while Wnt/β signaling, the pathway sclerostin antagonizes, increases in adipose tissue fol. These results provide observational evidence for an endocrine role of sclerostin in humans and suggest a role of sclerostin/Wnt signaling in exercise induced adipose tissue adaptations. |
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| AbstractList | Abstract Sclerostin is a Wnt/β‐catenin antagonist, mainly secreted by osteocytes, and most known for its role in reducing bone formation. Studies in rodents suggest sclerostin can also regulate adipose tissue mass and metabolism, representing bone–adipose tissue crosstalk. Exercise training has been shown to reduce plasma sclerostin levels; but the effects of exercise on sclerostin and Wnt/β‐catenin signaling specifically within adipose tissue has yet to be examined. The purpose of this study was to examine subcutaneous WAT (scWAT) sclerostin content and Wnt signaling in response to exercise training in young men with obesity. To this end, 7 male participants (BMI = 35 ± 4; 25 ± 4 years) underwent 4 weeks of sprint interval training (SIT) involving 4 weekly sessions consisting of a 5‐min warmup, followed by 8 × 20 s intervals at 170% of work rate at VO2peak, separated by 10 s of rest. Serum and scWAT were sampled at rest both pre‐ and post‐SIT. Despite no changes in serum sclerostin levels, we found a significant decrease in adipose sclerostin content (−37%, p = 0.04), an increase in total β‐catenin (+52%, p = 0.03), and no changes in GSK3β serine 9 phosphorylation. There were also concomitant reductions in serum TNF‐α (−0.36 pg/ml, p = 0.03) and IL‐6 (−1.44 pg/ml, p = 0.05) as well as an increase in VO2peak (+5%, p = 0.03) and scWAT COXIV protein content (+95%, p = 0.04). In conclusion, scWAT sclerostin content was reduced and β‐catenin content was increased following SIT in young men with excess adiposity, suggesting a role of sclerostin in regulating human adipose tissue in response to exercise training. Sclerostin is a Wnt/β-catenin antagonist, mainly secreted by osteocytes, and most known for its role in reducing bone formation. Studies in rodents suggest sclerostin can also regulate adipose tissue mass and metabolism, representing bone-adipose tissue crosstalk. Exercise training has been shown to reduce plasma sclerostin levels; but the effects of exercise on sclerostin and Wnt/β-catenin signaling specifically within adipose tissue has yet to be examined. The purpose of this study was to examine subcutaneous WAT (scWAT) sclerostin content and Wnt signaling in response to exercise training in young men with obesity. To this end, 7 male participants (BMI = 35 ± 4; 25 ± 4 years) underwent 4 weeks of sprint interval training (SIT) involving 4 weekly sessions consisting of a 5-min warmup, followed by 8 × 20 s intervals at 170% of work rate at VO2peak , separated by 10 s of rest. Serum and scWAT were sampled at rest both pre- and post-SIT. Despite no changes in serum sclerostin levels, we found a significant decrease in adipose sclerostin content (-37%, p = 0.04), an increase in total β-catenin (+52%, p = 0.03), and no changes in GSK3β serine 9 phosphorylation. There were also concomitant reductions in serum TNF-α (-0.36 pg/ml, p = 0.03) and IL-6 (-1.44 pg/ml, p = 0.05) as well as an increase in VO2peak (+5%, p = 0.03) and scWAT COXIV protein content (+95%, p = 0.04). In conclusion, scWAT sclerostin content was reduced and β-catenin content was increased following SIT in young men with excess adiposity, suggesting a role of sclerostin in regulating human adipose tissue in response to exercise training.Sclerostin is a Wnt/β-catenin antagonist, mainly secreted by osteocytes, and most known for its role in reducing bone formation. Studies in rodents suggest sclerostin can also regulate adipose tissue mass and metabolism, representing bone-adipose tissue crosstalk. Exercise training has been shown to reduce plasma sclerostin levels; but the effects of exercise on sclerostin and Wnt/β-catenin signaling specifically within adipose tissue has yet to be examined. The purpose of this study was to examine subcutaneous WAT (scWAT) sclerostin content and Wnt signaling in response to exercise training in young men with obesity. To this end, 7 male participants (BMI = 35 ± 4; 25 ± 4 years) underwent 4 weeks of sprint interval training (SIT) involving 4 weekly sessions consisting of a 5-min warmup, followed by 8 × 20 s intervals at 170% of work rate at VO2peak , separated by 10 s of rest. Serum and scWAT were sampled at rest both pre- and post-SIT. Despite no changes in serum sclerostin levels, we found a significant decrease in adipose sclerostin content (-37%, p = 0.04), an increase in total β-catenin (+52%, p = 0.03), and no changes in GSK3β serine 9 phosphorylation. There were also concomitant reductions in serum TNF-α (-0.36 pg/ml, p = 0.03) and IL-6 (-1.44 pg/ml, p = 0.05) as well as an increase in VO2peak (+5%, p = 0.03) and scWAT COXIV protein content (+95%, p = 0.04). In conclusion, scWAT sclerostin content was reduced and β-catenin content was increased following SIT in young men with excess adiposity, suggesting a role of sclerostin in regulating human adipose tissue in response to exercise training. Sclerostin is a Wnt/β‐catenin antagonist, mainly secreted by osteocytes, and most known for its role in reducing bone formation. Studies in rodents suggest sclerostin can also regulate adipose tissue mass and metabolism, representing bone–adipose tissue crosstalk. Exercise training has been shown to reduce plasma sclerostin levels; but the effects of exercise on sclerostin and Wnt/β‐catenin signaling specifically within adipose tissue has yet to be examined. The purpose of this study was to examine subcutaneous WAT (scWAT) sclerostin content and Wnt signaling in response to exercise training in young men with obesity. To this end, 7 male participants (BMI = 35 ± 4; 25 ± 4 years) underwent 4 weeks of sprint interval training (SIT) involving 4 weekly sessions consisting of a 5‐min warmup, followed by 8 × 20 s intervals at 170% of work rate at VO2peak, separated by 10 s of rest. Serum and scWAT were sampled at rest both pre‐ and post‐SIT. Despite no changes in serum sclerostin levels, we found a significant decrease in adipose sclerostin content (−37%, p = 0.04), an increase in total β‐catenin (+52%, p = 0.03), and no changes in GSK3β serine 9 phosphorylation. There were also concomitant reductions in serum TNF‐α (−0.36 pg/ml, p = 0.03) and IL‐6 (−1.44 pg/ml, p = 0.05) as well as an increase in VO2peak (+5%, p = 0.03) and scWAT COXIV protein content (+95%, p = 0.04). In conclusion, scWAT sclerostin content was reduced and β‐catenin content was increased following SIT in young men with excess adiposity, suggesting a role of sclerostin in regulating human adipose tissue in response to exercise training. In this study, we examined sclerostin content in serum and subcutaneous adipose tissue both pre‐ and post‐exercise training in humans with obesity. Our data support that sclerostin decreases while Wnt/β signaling, the pathway sclerostin antagonizes, increases in adipose tissue fol. These results provide observational evidence for an endocrine role of sclerostin in humans and suggest a role of sclerostin/Wnt signaling in exercise induced adipose tissue adaptations. Sclerostin is a Wnt/β‐catenin antagonist, mainly secreted by osteocytes, and most known for its role in reducing bone formation. Studies in rodents suggest sclerostin can also regulate adipose tissue mass and metabolism, representing bone–adipose tissue crosstalk. Exercise training has been shown to reduce plasma sclerostin levels; but the effects of exercise on sclerostin and Wnt/β‐catenin signaling specifically within adipose tissue has yet to be examined. The purpose of this study was to examine subcutaneous WAT (scWAT) sclerostin content and Wnt signaling in response to exercise training in young men with obesity. To this end, 7 male participants (BMI = 35 ± 4; 25 ± 4 years) underwent 4 weeks of sprint interval training (SIT) involving 4 weekly sessions consisting of a 5‐min warmup, followed by 8 × 20 s intervals at 170% of work rate at VO 2peak , separated by 10 s of rest. Serum and scWAT were sampled at rest both pre‐ and post‐SIT. Despite no changes in serum sclerostin levels, we found a significant decrease in adipose sclerostin content (−37%, p = 0.04), an increase in total β‐catenin (+52%, p = 0.03), and no changes in GSK3β serine 9 phosphorylation. There were also concomitant reductions in serum TNF‐α (−0.36 pg/ml, p = 0.03) and IL‐6 (−1.44 pg/ml, p = 0.05) as well as an increase in VO 2peak (+5%, p = 0.03) and scWAT COXIV protein content (+95%, p = 0.04). In conclusion, scWAT sclerostin content was reduced and β‐catenin content was increased following SIT in young men with excess adiposity, suggesting a role of sclerostin in regulating human adipose tissue in response to exercise training. In this study, we examined sclerostin content in serum and subcutaneous adipose tissue both pre‐ and post‐exercise training in humans with obesity. Our data support that sclerostin decreases while Wnt/β signaling, the pathway sclerostin antagonizes, increases in adipose tissue fol. These results provide observational evidence for an endocrine role of sclerostin in humans and suggest a role of sclerostin/Wnt signaling in exercise induced adipose tissue adaptations. Sclerostin is a Wnt/β-catenin antagonist, mainly secreted by osteocytes, and most known for its role in reducing bone formation. Studies in rodents suggest sclerostin can also regulate adipose tissue mass and metabolism, representing bone-adipose tissue crosstalk. Exercise training has been shown to reduce plasma sclerostin levels; but the effects of exercise on sclerostin and Wnt/β-catenin signaling specifically within adipose tissue has yet to be examined. The purpose of this study was to examine subcutaneous WAT (scWAT) sclerostin content and Wnt signaling in response to exercise training in young men with obesity. To this end, 7 male participants (BMI = 35 ± 4; 25 ± 4 years) underwent 4 weeks of sprint interval training (SIT) involving 4 weekly sessions consisting of a 5-min warmup, followed by 8 × 20 s intervals at 170% of work rate at VO , separated by 10 s of rest. Serum and scWAT were sampled at rest both pre- and post-SIT. Despite no changes in serum sclerostin levels, we found a significant decrease in adipose sclerostin content (-37%, p = 0.04), an increase in total β-catenin (+52%, p = 0.03), and no changes in GSK3β serine 9 phosphorylation. There were also concomitant reductions in serum TNF-α (-0.36 pg/ml, p = 0.03) and IL-6 (-1.44 pg/ml, p = 0.05) as well as an increase in VO (+5%, p = 0.03) and scWAT COXIV protein content (+95%, p = 0.04). In conclusion, scWAT sclerostin content was reduced and β-catenin content was increased following SIT in young men with excess adiposity, suggesting a role of sclerostin in regulating human adipose tissue in response to exercise training. Sclerostin is a Wnt/β-catenin antagonist, mainly secreted by osteocytes, and most known for its role in reducing bone formation. Studies in rodents suggest sclerostin can also regulate adipose tissue mass and metabolism, representing bone–adipose tissue crosstalk. Exercise training has been shown to reduce plasma sclerostin levels; but the effects of exercise on sclerostin and Wnt/β-catenin signaling specifically within adipose tissue has yet to be examined. The purpose of this study was to examine subcutaneous WAT (scWAT) sclerostin content and Wnt signaling in response to exercise training in young men with obesity. To this end, 7 male participants (BMI = 35 ± 4; 25 ± 4 years) underwent 4 weeks of sprint interval training (SIT) involving 4 weekly sessions consisting of a 5-min warmup, followed by 8 × 20 s intervals at 170% of work rate at VO2peak, separated by 10 s of rest. Serum and scWAT were sampled at rest both pre- and post-SIT. Despite no changes in serum sclerostin levels, we found a significant decrease in adipose sclerostin content (−37%, p = 0.04), an increase in total β-catenin (+52%, p = 0.03), and no changes in GSK3β serine 9 phosphorylation. There were also concomitant reductions in serum TNF-α (−0.36 pg/ml, p = 0.03) and IL-6 (−1.44 pg/ml, p = 0.05) as well as an increase in VO2peak (+5%, p = 0.03) and scWAT COXIV protein content (+95%, p = 0.04). In conclusion, scWAT sclerostin content was reduced and β-catenin content was increased following SIT in young men with excess adiposity, suggesting a role of sclerostin in regulating human adipose tissue in response to exercise training. |
| Author | Stoikos, Joshua Kurgan, Nigel Gurd, Brendon J. Baranowski, Bradley J. Islam, Hashim Fajardo, Val A. MacPherson, Rebecca E. K. Matusiak, Jennifer B. L. Klentrou, Panagiota |
| AuthorAffiliation | 5 Department of Health Sciences Brock University St. Catharines Ontario Canada 1 Department of Kinesiology Brock University St. Catharines Ontario Canada 3 School of Health and Exercise Sciences University of British Columbia Okanagan Kelowna British Columbia Canada 4 Department of Kinesiology Queens University Kingston Ontario Canada 2 Centre for Bone and Muscle Health Brock University St. Catharines Ontario Canada |
| AuthorAffiliation_xml | – name: 4 Department of Kinesiology Queens University Kingston Ontario Canada – name: 1 Department of Kinesiology Brock University St. Catharines Ontario Canada – name: 5 Department of Health Sciences Brock University St. Catharines Ontario Canada – name: 3 School of Health and Exercise Sciences University of British Columbia Okanagan Kelowna British Columbia Canada – name: 2 Centre for Bone and Muscle Health Brock University St. Catharines Ontario Canada |
| Author_xml | – sequence: 1 givenname: Nigel orcidid: 0000-0002-5011-0297 surname: Kurgan fullname: Kurgan, Nigel organization: Brock University – sequence: 2 givenname: Hashim surname: Islam fullname: Islam, Hashim organization: University of British Columbia Okanagan – sequence: 3 givenname: Jennifer B. L. surname: Matusiak fullname: Matusiak, Jennifer B. L. organization: Queens University – sequence: 4 givenname: Bradley J. surname: Baranowski fullname: Baranowski, Bradley J. organization: Brock University – sequence: 5 givenname: Joshua surname: Stoikos fullname: Stoikos, Joshua organization: Brock University – sequence: 6 givenname: Val A. orcidid: 0000-0003-4500-3347 surname: Fajardo fullname: Fajardo, Val A. organization: Brock University – sequence: 7 givenname: Rebecca E. K. orcidid: 0000-0002-1577-2658 surname: MacPherson fullname: MacPherson, Rebecca E. K. organization: Brock University – sequence: 8 givenname: Brendon J. surname: Gurd fullname: Gurd, Brendon J. organization: Queens University – sequence: 9 givenname: Panagiota orcidid: 0000-0003-0328-5198 surname: Klentrou fullname: Klentrou, Panagiota email: nklentrou@brocku.ca organization: Brock University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35312183$$D View this record in MEDLINE/PubMed |
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| Keywords | bone-adipose tissue crosstalk Wnt signaling sprint interval training sclerostin |
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| Publisher_xml | – name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc – name: Wiley |
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| Snippet | Sclerostin is a Wnt/β‐catenin antagonist, mainly secreted by osteocytes, and most known for its role in reducing bone formation. Studies in rodents suggest... Sclerostin is a Wnt/β-catenin antagonist, mainly secreted by osteocytes, and most known for its role in reducing bone formation. Studies in rodents suggest... Abstract Sclerostin is a Wnt/β‐catenin antagonist, mainly secreted by osteocytes, and most known for its role in reducing bone formation. Studies in rodents... |
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| SubjectTerms | Adipocytes Adipose tissue beta Catenin - metabolism Biopsy Biosynthesis Body fat Bone growth Bone mass bone–adipose tissue crosstalk Carbohydrates Catenin Exercise Fitness training programs Gene expression High-Intensity Interval Training Humans Insulin resistance Interleukin 6 Interval training Laboratories Male Metabolism Obesity Obesity - therapy Original Osteocytes Osteogenesis Phosphorylation Physical fitness Physical training Proteins sclerostin SOST protein sprint interval training Subcutaneous Fat - metabolism Wnt protein Wnt signaling Wnt Signaling Pathway |
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| Title | Subcutaneous adipose tissue sclerostin is reduced and Wnt signaling is enhanced following 4‐weeks of sprint interval training in young men with obesity |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.14814%2Fphy2.15232 https://www.ncbi.nlm.nih.gov/pubmed/35312183 https://www.proquest.com/docview/2644245859 https://www.proquest.com/docview/2641516840 https://pubmed.ncbi.nlm.nih.gov/PMC8935536 https://doaj.org/article/e4032b7ba2364954a828f833fa10e006 |
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