Recent Advances in Continuous‐Flow Enantioselective Catalysis

• Published in: Chemistry : a European journal Vol. 26; no. 26; pp. 5729 - 5747
• Main Authors: Yu, Tao, Ding, Zhengwei, Nie, Wenzheng, Jiao, Jiao, Zhang, Hailong, Zhang, Qian, Xue, Chao, Duan, Xinhua, Yamada, Yoichi M. A., Li, Pengfei
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 07-05-2020
• Subjects: biocatalysts; Catalysis; Catalysts; Chemistry; Enantiomers; enantioselective catalysts; Fine chemicals; flow chemistry; heterogeneous catalysts; homogeneous catalysts; Industrial development; Pharmaceutical industry; biocatalysts; enantioselective catalysts; heterogeneous catalysts; homogeneous catalysts; flow chemistry
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.201905151

The increased demand for more efficient, safe, and green production in fine chemical and pharmaceutical industry calls for the development of continuous‐flow manufacturing, and for chiral chemicals in particular, enantioselective catalytic processes. In recent years, this emerging direction has received considerable attention and has seen rapid progress. In most cases, catalytic enantioselective flow processes using homogeneous, heterogeneous, or enzymatic catalysts have shown significant advantages over the conventional batch mode, such as shortened reaction times, lower catalysts loadings, and higher selectivities in addition to the normal merits of non‐enantioselective flow operations. In this Minireview, the advancements, key strategies, methods, and technologies developed the last six years as well as remaining challenges are summarized.
Going with the flow: In recent years, continuous‐flow techniques have received considerable attention and shown rapid progress in manufacturing. Among these, catalytic enantioselective flow processes using homogeneous, heterogeneous, or enzymatic catalysts have shown significant advantages over the conventional batch mode. In this Minireview, recent advances in continuous‐flow enantioselective catalysis are summarized and discussed, with emphasis on studies published after 2013.