Effects of supplemental oxygen on forearm vasodilation in humans

• Published in: Journal of applied physiology (1985) Vol. 82; no. 5; pp. 1601 - 1606
• Main Authors: Crawford, Paul, Good, Peter A, Gutierrez, Eric, Feinberg, Joshua H, Boehmer, John P, Silber, David H, Sinoway, Lawrence I
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01-05-1997; American Physiological Society
• Subjects: Adult; Biological and medical sciences; Blood Pressure - drug effects; Edema - etiology; Female; Forearm - blood supply; Forearm - innervation; Fundamental and applied biological sciences. Psychology; Heart Failure - complications; Heart Failure - drug therapy; Heart Rate - drug effects; Hemodynamics. Rheology; Humans; Lower Body Negative Pressure; Male; Oxygen - pharmacology; Oxygen Inhalation Therapy - adverse effects; Regional Blood Flow - drug effects; Space life sciences; Sympathetic Nervous System - physiology; Vascular Resistance - drug effects; Vasodilation - drug effects; Vertebrates: cardiovascular system; Human; Resistance; Oxygen; Forearm; Blood vessel; Lower limb; Upper limb; Circulatory system; Negative pressure; Non-programmatic
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1997.82.5.1601

Paul
Crawford,
Peter A.
Good,
Eric
Gutierrez,
Joshua H.
Feinberg,
John P.
Boehmer,
David H.
Silber, and
Lawrence I.
Sinoway
Division of Cardiology, The Milton S. Hershey Medical Center, The
Pennsylvania State University, Hershey 17033; and Lebanon Veterans
Affairs Medical Center, Lebanon, Pennsylvania 17042
Received 23 August 1996; accepted in final form 24
January 1997.
Crawford, Paul, Peter A. Good, Eric Gutierrez, Joshua H. Feinberg, John P. Boehmer, David H. Silber, and Lawrence I. Sinoway. Effects of supplemental oxygen on forearm vasodilation in humans.
J. Appl. Physiol. 82(5):
1601-1606, 1997. Supplemental O 2 reduces cardiac output and
raises systemic vascular resistance in congestive heart failure. In
this study, 100% O 2 was given to
normal subjects and peak forearm flow was measured. In
experiment 1 , 100%
O 2 reduced blood flow and
increased resistance after 10 min of forearm ischemia (flow 56.7 ± 7.9 vs. 47.8 ± 6.7 ml · min 1 · 100 ml 1 ;
P  < 0.02; vascular resistance 1.7 ± 0.2 vs. 2.4 ± 0.4 mmHg · min · 100 ml · ml 1 ;
P  < 0.03). In
experiment 2 , lower body negative
pressure (LBNP; 30 mmHg) and venous congestion (VC) simulated
the high sympathetic tone and edema of congestive heart failure.
Postischemic forearm flow and resistance were measured under four
conditions: room air breathing (RA); LBNP+RA; RA+LBNP+VC; and 100%
O 2 +LBNP+VC. LBNP and VC did not
lower peak flow. However, O 2
raised minimal resistance (2.3 ± 0.4 RA; 2.8 ± 0.5 O 2 +LBNP+VC,
P  < 0.04). When O 2 alone
( experiment 1 ) was compared with
O 2 +LBNP+VC
( experiment 2 ), no effect of LBNP+VC
on peak flow or minimum resistance was noted, although the return rate
of flow and resistance toward baseline was increased.
O 2 reduces peak forearm flow even
in the presence of LBNP and VC.
vascular resistance; lower body negative pressure; venous
congestion
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society