Modulatory Effects of Arctostaphylos uva-urs Extract In Ovo Injected into Broiler Embryos Contaminated by Aflatoxin B1

In ovo injection of nutrients can modulate the embryo’s physiological responses against aflatoxin B1 (AFB1) embryotoxicity. This hypothesis was tested using in ovo injection of Arctostaphylos uva-ursi (Ar. uu.) methanolic extract. The total polyphenols, total flavonoids, total antioxidant capacity,...

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Published in:	Animals (Basel) Vol. 12; no. 16; p. 2042
Main Authors:	Elwan, Hamada, Mohamed, Abdelhameed S A, Dawood, Dawood Hosni, Elnesr, Shaaban S
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 11-08-2022 MDPI
Subjects:	Acids Aflatoxin B1 Aflatoxins Antioxidants Arctostaphylos uva-ursi broiler Chicks Chromatography Contamination Diet Distilled water Eggs Embryos embryotoxicity Feeds Flavonoids Free radicals Immune response (humoral) Infections Injection Juveniles Kidneys Leukocytes Mortality Mycotoxins Nutrients Oils & fats Oxidative stress Physiological responses Physiology Phytochemicals Poisons Polyphenols Poultry Poultry production Preventive maintenance Survival Tibia Toxicity Yolk sac United States > US embryotoxicity aflatoxin B1 Arctostaphylos uva-ursi broiler
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Abstract	In ovo injection of nutrients can modulate the embryo’s physiological responses against aflatoxin B1 (AFB1) embryotoxicity. This hypothesis was tested using in ovo injection of Arctostaphylos uva-ursi (Ar. uu.) methanolic extract. The total polyphenols, total flavonoids, total antioxidant capacity, and GC-MS analysis were all assessed in the Ar. uu. methanolic extract. A total of 180 ten-day-old embryonated eggs were distributed into six groups of 30 replicates each. The first group was used as a control (non-injected), and the second, third, fourth, fifth, and sixth groups were injected with 10 µ double-distilled water (DDW), 500 µL methanol, 0.01 g Ar. uu./500 µL methanol, 50 ng AFB1/10 µL DDW, and 50 ng AFB1 in 10 µ DDW + 0.01 g Ar. uu./500 µL methanol, respectively. The relative embryo weight, residual yolk sac weight, tibia length and weight, and survival were recorded. Total and differential leukocytes, oxidative stress, and humoral immune responses were observed. The residual yolk sac was lower (p < 0.05) in the Ar. uu. group than other groups. The embryonic growth (tibia weight and length) was enhanced in AFB1 + Ar. uu.-injected embryos compared with those injected with AFB1 alone. In conclusion, in ovo injection of Arctostaphylos uva-ursi could modulate AFB1-induced toxicity in chicken embryos.
AbstractList	In ovo injection of nutrients can modulate the embryo’s physiological responses against aflatoxin B1 (AFB1) embryotoxicity. This hypothesis was tested using in ovo injection of Arctostaphylos uva-ursi (Ar. uu.) methanolic extract. The total polyphenols, total flavonoids, total antioxidant capacity, and GC-MS analysis were all assessed in the Ar. uu. methanolic extract. A total of 180 ten-day-old embryonated eggs were distributed into six groups of 30 replicates each. The first group was used as a control (non-injected), and the second, third, fourth, fifth, and sixth groups were injected with 10 µ double-distilled water (DDW), 500 µL methanol, 0.01 g Ar. uu./500 µL methanol, 50 ng AFB1/10 µL DDW, and 50 ng AFB1 in 10 µ DDW + 0.01 g Ar. uu./500 µL methanol, respectively. The relative embryo weight, residual yolk sac weight, tibia length and weight, and survival were recorded. Total and differential leukocytes, oxidative stress, and humoral immune responses were observed. The residual yolk sac was lower (p < 0.05) in the Ar. uu. group than other groups. The embryonic growth (tibia weight and length) was enhanced in AFB1 + Ar. uu.-injected embryos compared with those injected with AFB1 alone. In conclusion, in ovo injection of Arctostaphylos uva-ursi could modulate AFB1-induced toxicity in chicken embryos. Simple SummaryThe poultry industry is of great importance worldwide; however, mycotoxins contamination, especially aflatoxins, has harmful effects on poultry production. Therefore, finding out new strategies to alleviate aflatoxin contamination is an important trend of research. In our study, we focused on the in ovo injection techniques using the methanolic extract of brae beery “Arctostaphylos uva-ursi” (Ar. uu) to modulate the aflatoxinB1 (AFB1) adverse effects in broiler embryos. As a result, 0.1 g of Ar. uu in ovo injection alleviates AFB1 embryotoxicity by enhancing chicks’ physiological responses and optimizing antioxidant status, which is reflected in a low mortality rate and heavier relative weight of the hatched chicks. The in ovo injection of AFB1 + Ar. uu significantly declined AFB1-induced toxicity in embryos and increased broiler chicks embryo’s survival by 62.5%, increased relative embryo weight by ∼65.25% compared to eggs injected with AFB1 alone. Regarding immune responses, the in ovo injection of Ar. uu enhances the embryo’s humoral immune responses and regulates oxidative stress biomarkers. In general, the in ovo injection of Ar. uu modulates broiler chicks’ embryotoxicity caused by AFB1.AbstractIn ovo injection of nutrients can modulate the embryo’s physiological responses against aflatoxin B1 (AFB1) embryotoxicity. This hypothesis was tested using in ovo injection of Arctostaphylos uva-ursi (Ar. uu.) methanolic extract. The total polyphenols, total flavonoids, total antioxidant capacity, and GC-MS analysis were all assessed in the Ar. uu. methanolic extract. A total of 180 ten-day-old embryonated eggs were distributed into six groups of 30 replicates each. The first group was used as a control (non-injected), and the second, third, fourth, fifth, and sixth groups were injected with 10 µ double-distilled water (DDW), 500 µL methanol, 0.01 g Ar. uu./500 µL methanol, 50 ng AFB1/10 µL DDW, and 50 ng AFB1 in 10 µ DDW + 0.01 g Ar. uu./500 µL methanol, respectively. The relative embryo weight, residual yolk sac weight, tibia length and weight, and survival were recorded. Total and differential leukocytes, oxidative stress, and humoral immune responses were observed. The residual yolk sac was lower (p < 0.05) in the Ar. uu. group than other groups. The embryonic growth (tibia weight and length) was enhanced in AFB1 + Ar. uu.-injected embryos compared with those injected with AFB1 alone. In conclusion, in ovo injection of Arctostaphylos uva-ursi could modulate AFB1-induced toxicity in chicken embryos.
Author	Dawood, Dawood Hosni Elnesr, Shaaban S Elwan, Hamada Mohamed, Abdelhameed S A
AuthorAffiliation	3 Department of Poultry Production, Faculty of Agriculture, Fayoum University, Fayoum 63514, Egypt 1 Animal and Poultry Production Department, Faculty of Agriculture, Minia University, El-Minya 61519, Egypt 2 Agricultural Chemistry Department, Faculty of Agriculture, Mansoura University, Mansoura 35516, Egypt
AuthorAffiliation_xml	– name: 3 Department of Poultry Production, Faculty of Agriculture, Fayoum University, Fayoum 63514, Egypt – name: 1 Animal and Poultry Production Department, Faculty of Agriculture, Minia University, El-Minya 61519, Egypt – name: 2 Agricultural Chemistry Department, Faculty of Agriculture, Mansoura University, Mansoura 35516, Egypt
Author_xml	– sequence: 1 givenname: Hamada orcidid: 0000-0002-4497-1322 surname: Elwan fullname: Elwan, Hamada organization: Animal and Poultry Production Department, Faculty of Agriculture, Minia University, El-Minya 61519, Egypt – sequence: 2 givenname: Abdelhameed S A surname: Mohamed fullname: Mohamed, Abdelhameed S A organization: Animal and Poultry Production Department, Faculty of Agriculture, Minia University, El-Minya 61519, Egypt – sequence: 3 givenname: Dawood Hosni orcidid: 0000-0003-1590-1461 surname: Dawood fullname: Dawood, Dawood Hosni organization: Agricultural Chemistry Department, Faculty of Agriculture, Mansoura University, Mansoura 35516, Egypt – sequence: 4 givenname: Shaaban S orcidid: 0000-0002-4430-1492 surname: Elnesr fullname: Elnesr, Shaaban S organization: Department of Poultry Production, Faculty of Agriculture, Fayoum University, Fayoum 63514, Egypt
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/36009632$$D View this record in MEDLINE/PubMed
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Keywords	embryotoxicity aflatoxin B1 Arctostaphylos uva-ursi broiler
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Snippet	In ovo injection of nutrients can modulate the embryo’s physiological responses against aflatoxin B1 (AFB1) embryotoxicity. This hypothesis was tested using in... Simple SummaryThe poultry industry is of great importance worldwide; however, mycotoxins contamination, especially aflatoxins, has harmful effects on poultry...
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SubjectTerms	Acids Aflatoxin B1 Aflatoxins Antioxidants Arctostaphylos uva-ursi broiler Chicks Chromatography Contamination Diet Distilled water Eggs Embryos embryotoxicity Feeds Flavonoids Free radicals Immune response (humoral) Infections Injection Juveniles Kidneys Leukocytes Mortality Mycotoxins Nutrients Oils & fats Oxidative stress Physiological responses Physiology Phytochemicals Poisons Polyphenols Poultry Poultry production Preventive maintenance Survival Tibia Toxicity Yolk sac
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Title	Modulatory Effects of Arctostaphylos uva-urs Extract In Ovo Injected into Broiler Embryos Contaminated by Aflatoxin B1
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