Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs

Poly(A)-binding protein 1 (PABP1) has a fundamental role in the regulation of mRNA translation and stability, both of which are crucial for a wide variety of cellular processes. Although generally a diffuse cytoplasmic protein, it can be found in discrete foci such as stress and neuronal granules. M...

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Bibliographic Details
Published in:	Journal of cell science Vol. 124; no. Pt 19; pp. 3344 - 3355
Main Authors:	Burgess, Hannah M, Richardson, William A, Anderson, Ross C, Salaun, Christine, Graham, Sheila V, Gray, Nicola K
Format:	Journal Article
Language:	English
Published:	England Company of Biologists 01-10-2011
Subjects:	Active Transport, Cell Nucleus Animals Apoptosis - radiation effects Blood Proteins - metabolism Cell Nucleus - metabolism Cytoplasm - metabolism Cytoplasmic Granules - metabolism HeLa Cells Humans Immediate-Early Proteins - biosynthesis Metazoa Mice Microscopy, Fluorescence NIH 3T3 Cells Poly(A)-Binding Protein I - metabolism Poly(A)-Binding Proteins - metabolism Protein Biosynthesis Protein Transport - radiation effects Recombinant Proteins - biosynthesis RNA Transport RNA, Messenger - metabolism Ultraviolet Rays
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