Nitrolinoleate Inhibits Platelet Activation by Attenuating Calcium Mobilization and Inducing Phosphorylation of Vasodilator-stimulated Phosphoprotein through Elevation of cAMP

Reactive species formed from nitric oxide (NO) nitrate unsaturated fatty acids such as linoleate (LA) to nitrated derivatives including nitrolinoleate (LNO2). The effect of LNO2 on human platelets was examined to define how nitrated lipids might behave in vivo. LNO2, but not LA or 3-nitrotyrosine, d...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 277; no. 8; pp. 5832 - 5840
Main Authors:	Coles, Barbara, Bloodsworth, Allison, Eiserich, Jason P., Coffey, Marcus J., McLoughlin, Rachel M., Giddings, John C., Lewis, Malcolm J., Haslam, Richard J., Freeman, Bruce A., O'Donnell, Valerie B.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 22-02-2002 American Society for Biochemistry and Molecular Biology
Subjects:	1-Methyl-3-isobutylxanthine - pharmacology Blood Platelets - drug effects Blood Platelets - physiology Calcium - blood Calcium Signaling - drug effects Calcium Signaling - physiology Cyclic AMP - metabolism Cyclic GMP - metabolism Humans In Vitro Techniques Kinetics Linoleic Acid - pharmacology Linoleic Acids - chemical synthesis Linoleic Acids - pharmacology Nitro Compounds - chemical synthesis Nitro Compounds - pharmacology Phosphoproteins - metabolism Phosphorylation Platelet Activation - drug effects Platelet Activation - physiology Platelet Aggregation - drug effects Platelet Aggregation - physiology Thrombin - pharmacology Tyrosine - analogs & derivatives Tyrosine - pharmacology Vasodilator Agents - pharmacology
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