APL-2, an altered peptide ligand derived from heat-shock protein 60, induces interleukin-10 in peripheral blood mononuclear cell derived from juvenile idiopathic arthritis patients and downregulates the inflammatory response in collagen-induced arthritis model

Juvenile idiopathic arthritis (JIA) is a heterogeneous group of diseases characterized by autoimmune arthritis of unknown cause with onset before age of 16 years. Methotrexate provides clinical benefits in JIA. For children who do not respond to methotrexate, treatment with anti-tumor necrosis facto...

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Bibliographic Details
Published in:	Clinical and experimental medicine Vol. 15; no. 1; pp. 31 - 39
Main Authors:	Lorenzo, Norailys, Cantera, Dolores, Barberá, Ariana, Alonso, Amaris, Chall, Elsy, Franco, Lourdes, Ancizar, Julio, Nuñez, Yanetsy, Altruda, Fiorella, Silengo, Lorenzo, Padrón, Gabriel, del Carmen Dominguez, Maria
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-02-2015 Springer Nature B.V
Subjects:	Adolescent Animals Antirheumatic Agents - pharmacology Arthritis Arthritis, Experimental - drug therapy Arthritis, Experimental - genetics Arthritis, Experimental - immunology Arthritis, Experimental - pathology Arthritis, Juvenile - genetics Arthritis, Juvenile - immunology Arthritis, Juvenile - pathology Autoantigens - chemistry Autoantigens - pharmacology Chaperonin 60 - chemistry Chaperonin 60 - genetics Chaperonin 60 - immunology Child Child, Preschool Collagen Gene Expression Regulation Hematology Humans Interferon-gamma - biosynthesis Interferon-gamma - secretion Interleukin-10 - biosynthesis Interleukin-10 - secretion Interleukin-17 - antagonists & inhibitors Interleukin-17 - biosynthesis Interleukin-17 - secretion Internal Medicine Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - pathology Medicine Medicine & Public Health Methotrexate - pharmacology Mice Mitochondrial Proteins - chemistry Mitochondrial Proteins - genetics Mitochondrial Proteins - immunology Oncology Original Article Peptides Peptides - chemical synthesis Peptides - pharmacology Peripheral Tolerance Primary Cell Culture Proteins Signal Transduction Sulfasalazine - pharmacology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - secretion Tolerance Altered peptide ligand Interleukin-10 Collagen-induced arthritis Juvenile idiopathic arthritis
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