Structure, Synthesis, and Biological Activity of 14-Methoxy-1,2-dehydrocacalol Methyl Ether, a New Modified Furanoeremophilane Type Sesquiterpene from Trichilia cuneata

Structure, Synthesis, and Biological Activity of 14-Methoxy-1,2-dehydrocacalol Methyl Ether, a New Modified Furanoeremophilane Type Sesquiterpene from Trichilia cuneata

A new modified furanoeremophilane type sesquiterpene, (+)-14-methoxy-1,2-dehydrocacalol methyl ether (2), isolated from Trichilia cuneata exhibited inhibitory activity for mitochondrial lipid peroxidation. The first total synthesis of (±)-2 and two related sesquiterpenes, (±)-14-hydroxycacalol methy...

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Bibliographic Details
Published in:Chemistry letters Vol. 33; no. 6; pp. 714 - 715
Main Authors: Doe, Matsumi, Hirai, Yoshinori, Kinoshita, Takamasa, Shibata, Kozo, Haraguchi, Hiroyuki, Morimoto, Yoshiki
Format: Journal Article
Language:English
Published: Tokyo The Chemical Society of Japan 01-06-2004
Chemical Society of Japan
Online Access:Get full text
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Summary:A new modified furanoeremophilane type sesquiterpene, (+)-14-methoxy-1,2-dehydrocacalol methyl ether (2), isolated from Trichilia cuneata exhibited inhibitory activity for mitochondrial lipid peroxidation. The first total synthesis of (±)-2 and two related sesquiterpenes, (±)-14-hydroxycacalol methyl ether (7) and 14-methoxydehydrocacalohastine (8), has also been achieved.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2004.714