Multidrug-Resistant and Genetic Characterization of Extended-Spectrum Beta-Lactamase-Producing E. coli Recovered from Chickens and Humans in Egypt

Colonization of food chain animals such as chickens with extended-spectrum β-lactamases (ESBL) poses a major health threat to human. The current study aimed to determine the phenotypic and genotypic relationship between ESBL-producing from diseased human and chickens in Egypt. A total of 56 out of 1...

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Published in:	Animals (Basel) Vol. 12; no. 3; p. 346
Main Authors:	Badr, Heba, Reda, Reem M, Hagag, Naglaa M, Kamel, Essam, Elnomrosy, Sara M, Mansour, Amal I, Shahein, Momtaz A, Ali, Samah F, Ali, Hala R
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 31-01-2022 MDPI
Subjects:	Animals Annealing antibiotic resistance Antibiotics Bacteria Chickens Colonization E coli ESBL Farms Feces Food chains Food sources Genes Genetic testing Genotypes Health risks human Infections Laboratories Morbidity Multidrug resistance Nucleotides Phenotypes Poultry Poultry farming Prophylaxis Similarity Zoonoses β Lactamase United Kingdom > UK United States > US Europe Germany Egypt ESBL poultry antibiotic resistance human E. coli
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Abstract	Colonization of food chain animals such as chickens with extended-spectrum β-lactamases (ESBL) poses a major health threat to human. The current study aimed to determine the phenotypic and genotypic relationship between ESBL-producing from diseased human and chickens in Egypt. A total of 56 out of 120 chicken farms (46.7%) and 9 human samples (100%) were phenotypically and genotypically identified with at least one ESBL-phenotype/gene. Chicken isolates showed a high proportion of beta lactamase from CTX-M group 9 > TEM > PER families, followed by CTX-M group 1 > SHV > GES > OXA group10 > VEB > OXA group2 families, while human isolates only contained the CTX-M family. A high incidence of ESBL genes from the CTX-M family was recognized in both human and chicken isolates. Furthermore, nucleotide identity showed high similarity between chicken and human isolates. In conclusion, the current study traced phenotypes and genotypes of ESBL-producing from chickens and human samples in Egypt, reporting degrees of similarity that suggest potential zoonotic transmission. Our data highlighted the significant importance of chicken as a major food source not only in Egypt but all over the world in the spreading of ESBL-producing to human.
AbstractList	Colonization of food chain animals such as chickens with extended-spectrum β-lactamases (ESBL) poses a major health threat to human. The current study aimed to determine the phenotypic and genotypic relationship between ESBL-producing from diseased human and chickens in Egypt. A total of 56 out of 120 chicken farms (46.7%) and 9 human samples (100%) were phenotypically and genotypically identified with at least one ESBL-phenotype/gene. Chicken isolates showed a high proportion of beta lactamase from CTX-M group 9 > TEM > PER families, followed by CTX-M group 1 > SHV > GES > OXA group10 > VEB > OXA group2 families, while human isolates only contained the CTX-M family. A high incidence of ESBL genes from the CTX-M family was recognized in both human and chicken isolates. Furthermore, nucleotide identity showed high similarity between chicken and human isolates. In conclusion, the current study traced phenotypes and genotypes of ESBL-producing from chickens and human samples in Egypt, reporting degrees of similarity that suggest potential zoonotic transmission. Our data highlighted the significant importance of chicken as a major food source not only in Egypt but all over the world in the spreading of ESBL-producing to human. Colonization of food chain animals such as chickens with extended-spectrum β-lactamases (ESBL) poses a major health threat to human. The current study aimed to determine the phenotypic and genotypic relationship between ESBL-producing E. coli from diseased human and chickens in Egypt. A total of 56 out of 120 chicken farms (46.7%) and 9 human samples (100%) were phenotypically and genotypically identified with at least one ESBL-phenotype/gene. Chicken isolates showed a high proportion of beta lactamase from CTX-M group 9 > TEM > PER families, followed by CTX-M group 1 > SHV > GES > OXA group10 > VEB > OXA group2 families, while human isolates only contained the CTX-M family. A high incidence of ESBL genes from the CTX-M family was recognized in both human and chicken isolates. Furthermore, nucleotide identity showed high similarity between chicken and human isolates. In conclusion, the current study traced phenotypes and genotypes of ESBL-producing E. coli from chickens and human samples in Egypt, reporting degrees of similarity that suggest potential zoonotic transmission. Our data highlighted the significant importance of chicken as a major food source not only in Egypt but all over the world in the spreading of ESBL-producing E. coli to human. Simple SummaryFeeding food chain animals with sub-therapeutic doses for prophylaxis or for growth-promoting purposes has led to the emergence of resistant bugs such as ESBL-E. coli. Infections caused by these superbugs are tremendously associated with treatment failures and high morbidity/mortality rates. Scarce information is currently available on the relation between the incidence of ESBL-E. coli in human and food chain animals in Egypt. The current study analyzed chicken and human fecal samples for isolation and characterization of ESBL-producing E. coli followed by sequencing the isolates. Significant similarities were detected between human and chicken isolates, indicating the possibility of zoonotic transmission. In conclusion, the study encouraged managing the use of antibiotics in veterinary field, to reduce the selection and spread of life-threating bugs to humans.AbstractColonization of food chain animals such as chickens with extended-spectrum β-lactamases (ESBL) poses a major health threat to human. The current study aimed to determine the phenotypic and genotypic relationship between ESBL-producing E. coli from diseased human and chickens in Egypt. A total of 56 out of 120 chicken farms (46.7%) and 9 human samples (100%) were phenotypically and genotypically identified with at least one ESBL-phenotype/gene. Chicken isolates showed a high proportion of beta lactamase from CTX-M group 9 > TEM > PER families, followed by CTX-M group 1 > SHV > GES > OXA group10 > VEB > OXA group2 families, while human isolates only contained the CTX-M family. A high incidence of ESBL genes from the CTX-M family was recognized in both human and chicken isolates. Furthermore, nucleotide identity showed high similarity between chicken and human isolates. In conclusion, the current study traced phenotypes and genotypes of ESBL-producing E. coli from chickens and human samples in Egypt, reporting degrees of similarity that suggest potential zoonotic transmission. Our data highlighted the significant importance of chicken as a major food source not only in Egypt but all over the world in the spreading of ESBL-producing E. coli to human.
Author	Ali, Hala R Shahein, Momtaz A Elnomrosy, Sara M Kamel, Essam Reda, Reem M Ali, Samah F Badr, Heba Mansour, Amal I Hagag, Naglaa M
AuthorAffiliation	6 Bacteriology Department, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Giza 12618, Egypt; samah_hefny2004@yahoo.com 4 Bacteriology, Food and Agriculture Organization of the United Nations, Giza 2223, Egypt; Amal.Mansour@fao.org 5 Department of Virology Research, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt; momtaz.shahein@yahoo.com 1 Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt; drheba_badr@yahoo.com (H.B.); reda_reem@yahoo.com (R.M.R.); naglaahagagahri@gmail.com (N.M.H.) 2 Department of chemistry, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt; essamkamel1@yahoo.com 3 Genome Research Unit, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt; dr_sara_vet_2007@yahoo.com
AuthorAffiliation_xml	– name: 2 Department of chemistry, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt; essamkamel1@yahoo.com – name: 3 Genome Research Unit, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt; dr_sara_vet_2007@yahoo.com – name: 1 Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt; drheba_badr@yahoo.com (H.B.); reda_reem@yahoo.com (R.M.R.); naglaahagagahri@gmail.com (N.M.H.) – name: 5 Department of Virology Research, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt; momtaz.shahein@yahoo.com – name: 4 Bacteriology, Food and Agriculture Organization of the United Nations, Giza 2223, Egypt; Amal.Mansour@fao.org – name: 6 Bacteriology Department, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Giza 12618, Egypt; samah_hefny2004@yahoo.com
Author_xml	– sequence: 1 givenname: Heba surname: Badr fullname: Badr, Heba organization: Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt – sequence: 2 givenname: Reem M surname: Reda fullname: Reda, Reem M organization: Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt – sequence: 3 givenname: Naglaa M surname: Hagag fullname: Hagag, Naglaa M organization: Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt – sequence: 4 givenname: Essam orcidid: 0000-0002-7223-483X surname: Kamel fullname: Kamel, Essam organization: Department of chemistry, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt – sequence: 5 givenname: Sara M surname: Elnomrosy fullname: Elnomrosy, Sara M organization: Genome Research Unit, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt – sequence: 6 givenname: Amal I orcidid: 0000-0003-4851-7108 surname: Mansour fullname: Mansour, Amal I organization: Bacteriology, Food and Agriculture Organization of the United Nations, Giza 2223, Egypt – sequence: 7 givenname: Momtaz A surname: Shahein fullname: Shahein, Momtaz A organization: Department of Virology Research, Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt – sequence: 8 givenname: Samah F orcidid: 0000-0002-1257-3602 surname: Ali fullname: Ali, Samah F organization: Bacteriology Department, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Giza 12618, Egypt – sequence: 9 givenname: Hala R orcidid: 0000-0001-5879-2176 surname: Ali fullname: Ali, Hala R organization: Bacteriology Department, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Giza 12618, Egypt
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Snippet	Colonization of food chain animals such as chickens with extended-spectrum β-lactamases (ESBL) poses a major health threat to human. The current study aimed to... Simple SummaryFeeding food chain animals with sub-therapeutic doses for prophylaxis or for growth-promoting purposes has led to the emergence of resistant bugs...
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SubjectTerms	Animals Annealing antibiotic resistance Antibiotics Bacteria Chickens Colonization E coli ESBL Farms Feces Food chains Food sources Genes Genetic testing Genotypes Health risks human Infections Laboratories Morbidity Multidrug resistance Nucleotides Phenotypes Poultry Poultry farming Prophylaxis Similarity Zoonoses β Lactamase
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Title	Multidrug-Resistant and Genetic Characterization of Extended-Spectrum Beta-Lactamase-Producing E. coli Recovered from Chickens and Humans in Egypt
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