The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice

The voltage-gated potassium channel Kv4.2 is a critical regulator of dendritic excitability in the hippocampus and is crucial for dendritic signal integration. Kv4.2 mRNA and protein expression as well as function are reduced in several genetic and pharmacologically induced rodent models of epilepsy...

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Bibliographic Details
Published in:	Experimental neurology Vol. 334; p. 113437
Main Authors:	Tiwari, Durgesh, Schaefer, Tori L., Schroeder-Carter, Lindsay M., Krzeski, Joseph C., Bunk, Alexander T., Parkins, Emma V., Snider, Andrew, Danzer, Reese, Williams, Michael T., Vorhees, Charles V., Danzer, Steve C., Gross, Christina
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2020
Subjects:	A-type potassium channel Animals Autism Dendritic spine morphology Dendritic Spines - metabolism Electroencephalography Electroencephalography - methods Epilepsy Female Genetic Predisposition to Disease HEK293 Cells Hippocampus - cytology Hippocampus - metabolism Humans Kv4.2 Lentiviral overexpression Male Maze Learning - physiology Mice Mice, Inbred C57BL Mice, Transgenic Seizure Seizures - genetics Seizures - metabolism Seizures - physiopathology Shal Potassium Channels - biosynthesis Shal Potassium Channels - genetics Dendritic spine morphology Autism Epilepsy Kv4.2 Seizure Electroencephalography A-type potassium channel Lentiviral overexpression
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