Synthesis and Cytotoxic Activity of Benzo[a]pyrano[3,2-h] and [2,3-i]xanthone Analogues of Psorospermine, Acronycine, and Benzo[a]acronycine

Condensation of 2-hydroxy-1-naphthalenecarboxylic acid with phloroglucinol afforded 9,11-dihydroxy-12H-benzo[a]xanthen-12-one (6). Construction of an additional dimethylpyran ring onto this skeleton, by alkylation with 3-chloro-3-methyl-1-butyne followed by Claisen rearrangement, gave access to 6-hy...

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Bibliographic Details
Published in:	Chemical & pharmaceutical bulletin Vol. 54; no. 8; pp. 1113 - 1118
Main Authors:	Sittisombut, Chavalit, Boutefnouchet, Sabrina, Van-Dufat, Hanh Trinh, Tian, Wen, Michel, Sylvie, Koch, Michel, Tillequin, François, Pfeiffer, Bruno, Pierré, Alain
Format:	Journal Article
Language:	English
Published:	Japan The Pharmaceutical Society of Japan 01-08-2006 Japan Science and Technology Agency
Subjects:	Acronine - analogs & derivatives Acronine - chemical synthesis Acronine - chemistry Acronine - pharmacology acronycine Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzo(a)pyrene - analogs & derivatives Benzo(a)pyrene - chemistry Benzo(a)pyrene - pharmacology benzopyranoxanthone Cell Line, Tumor Cell Proliferation - drug effects cytotoxicity Drug Screening Assays, Antitumor Humans Inhibitory Concentration 50 Mice Molecular Structure synthesis Xanthones - chemical synthesis Xanthones - chemistry Xanthones - pharmacology
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