Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies

• Published in: Pediatric research Vol. 95; no. 7; pp. 1698 - 1708
• Main Authors: White, Tegan A., Miller, Suzanne L., Sutherland, Amy E., Allison, Beth J., Camm, Emily J.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01-06-2024; Nature Publishing Group
• Subjects: Attention deficit hyperactivity disorder; Babies; Clinical outcomes; Medicine; Medicine & Public Health; Neonatal care; Neurodevelopmental disorders; Neurogenesis; Pediatric Surgery; Pediatrics; Pregnancy complications; Review; Review Article
• ISSN: 0031-3998; 1530-0447; 1530-0447
• DOI: 10.1038/s41390-024-03105-7

The hippocampus is a neuron-rich specialised brain structure that plays a central role in the regulation of emotions, learning and memory, cognition, spatial navigation, and motivational processes. In human fetal development, hippocampal neurogenesis is principally complete by mid-gestation, with subsequent maturation comprising dendritogenesis and synaptogenesis in the third trimester of pregnancy and infancy. Dendritogenesis and synaptogenesis underpin connectivity. Hippocampal development is exquisitely sensitive to perturbations during pregnancy and at birth. Clinical investigations demonstrate that preterm birth, fetal growth restriction (FGR), and acute hypoxic-ischaemic encephalopathy (HIE) are common perinatal complications that alter hippocampal development. In turn, deficits in hippocampal development and structure mediate a range of neurodevelopmental disorders, including cognitive and learning problems, autism, and Attention-Deficit/Hyperactivity Disorder (ADHD). In this review, we summarise the developmental profile of the hippocampus during fetal and neonatal life and examine the hippocampal deficits observed following common human pregnancy complications.
Impact
The review provides a comprehensive summary of the developmental profile of the hippocampus in normal fetal and neonatal life.
We address a significant knowledge gap in paediatric research by providing a comprehensive summary of the relationship between pregnancy complications and subsequent hippocampal damage, shedding new light on this critical aspect of early neurodevelopment.