Epidemiological and Experimental Aspects of Metal Carcinogenesis: Physicochemical Properties, Kinetics, and the Active Species

The carcinogenic properties of selected metals and their compounds are reviewed to provide a useful reference for existing knowledge on relationships between physical and chemical forms, kinetics and carcinogenic potential and between epidemiology, bioassays, and short-term tests. Extensive consider...

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Bibliographic Details
Published in:	Environmental health perspectives Vol. 95; pp. 157 - 189
Main Author:	Magos, Laszlo
Format:	Journal Article
Language:	English
Published:	United States National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare 01-11-1991
Subjects:	560300 - Chemicals Metabolism & Toxicology ADENOMAS ALKALINE EARTH METALS ANIMALS ARSENIC Arsenic - adverse effects Arsenic - pharmacokinetics BERYLLIUM Beryllium - adverse effects Beryllium - pharmacokinetics BIOASSAY BIOLOGICAL EFFECTS BODY Cadmium Cadmium - adverse effects Cadmium - pharmacokinetics CADMIUM COMPOUNDS CARCINOGENESIS Chromium Chromium - adverse effects Chromium - pharmacokinetics CHROMIUM COMPOUNDS Cricetinae Cricetulus DISEASES Dogs ELEMENTS Embryonic cells Epidemiologic Methods EPIDEMIOLOGY Guinea Pigs Humans IRON COMPOUNDS KINETICS Lead Lead - adverse effects Lead - pharmacokinetics LEAD COMPOUNDS Lung neoplasms Lungs Macaca mulatta Male MAMMALS MANGANESE COMPOUNDS Mesocricetus METALS Metals - adverse effects Metals - pharmacokinetics Mice Mortality Mutagenicity Tests NEOPLASMS Neoplasms - chemically induced Nickel - adverse effects Nickel - pharmacokinetics NICKEL COMPOUNDS ORGANS PATHOGENESIS RABBITS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS Rats, Inbred F344 Rats, Inbred Strains RODENTS SELENIUM COMPOUNDS SEMIMETALS SKIN TRANSITION ELEMENT COMPOUNDS Tumors VERTEBRATES
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Summary:	The carcinogenic properties of selected metals and their compounds are reviewed to provide a useful reference for existing knowledge on relationships between physical and chemical forms, kinetics and carcinogenic potential and between epidemiology, bioassays, and short-term tests. Extensive consideration is given to arsenic, beryllium, cadmium, chromium, lead, and nickel. Other metals such as antimony, cobalt, copper, iron, manganese, selenium, and zinc are discussed briefly.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Review-3
ISSN:	0091-6765 1552-9924
DOI:	10.1289/ehp.9195157