Measurement of β‐hydroxybutyrate in acute hyperketonemia in human brain
We report the measurement of d‐β‐hydroxybutyrate (BHB) in the brains of six normal adult subjects during acute infusions of BHB. We used high field in vivo1H magnetic resonance (MR) spectroscopy in the occipital lobe in conjunction with an acute infusion protocol to elevate plasma BHB levels from ov...
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| Published in: | Journal of neurochemistry Vol. 79; no. 3; pp. 539 - 544 |
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| Language: | English |
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Blackwell Science Ltd
01-11-2001
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| Abstract | We report the measurement of d‐β‐hydroxybutyrate (BHB) in the brains of six normal adult subjects during acute infusions of BHB. We used high field in vivo1H magnetic resonance (MR) spectroscopy in the occipital lobe in conjunction with an acute infusion protocol to elevate plasma BHB levels from overnight fasted levels (0.20 ± 0.10 mm) to a steady state value of 2.12 ± 0.30 mm. At this level of hyperketonemia, we determined a tissue BHB level of 0.24 ± 0.04 mm. No increases in brain lactate levels were seen in these data. The concentrations of BHB and lactate were both considerably lower in comparison with previous data acquired in fasted adult subjects. This suggests that up‐regulation of the monocarboxylic acid transporter occurs with fasting. |
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| AbstractList | We report the measurement of d‐β‐hydroxybutyrate (BHB) in the brains of six normal adult subjects during acute infusions of BHB. We used high field in vivo1H magnetic resonance (MR) spectroscopy in the occipital lobe in conjunction with an acute infusion protocol to elevate plasma BHB levels from overnight fasted levels (0.20 ± 0.10 mm) to a steady state value of 2.12 ± 0.30 mm. At this level of hyperketonemia, we determined a tissue BHB level of 0.24 ± 0.04 mm. No increases in brain lactate levels were seen in these data. The concentrations of BHB and lactate were both considerably lower in comparison with previous data acquired in fasted adult subjects. This suggests that up‐regulation of the monocarboxylic acid transporter occurs with fasting. We report the measurement of d ‐β‐hydroxybutyrate (BHB) in the brains of six normal adult subjects during acute infusions of BHB. We used high field in vivo 1 H magnetic resonance (MR) spectroscopy in the occipital lobe in conjunction with an acute infusion protocol to elevate plasma BHB levels from overnight fasted levels (0.20 ± 0.10 m m ) to a steady state value of 2.12 ± 0.30 m m . At this level of hyperketonemia, we determined a tissue BHB level of 0.24 ± 0.04 m m . No increases in brain lactate levels were seen in these data. The concentrations of BHB and lactate were both considerably lower in comparison with previous data acquired in fasted adult subjects. This suggests that up‐regulation of the monocarboxylic acid transporter occurs with fasting. We report the measurement of D-beta-hydroxybutyrate (BHB) in the brains of six normal adult subjects during acute infusions of BHB. We used high field in vivo (1)H magnetic resonance (MR) spectroscopy in the occipital lobe in conjunction with an acute infusion protocol to elevate plasma BHB levels from overnight fasted levels (0.20 +/- 0.10 mM) to a steady state value of 2.12 +/- 0.30 mM. At this level of hyperketonemia, we determined a tissue BHB level of 0.24 +/- 0.04 mM. No increases in brain lactate levels were seen in these data. The concentrations of BHB and lactate were both considerably lower in comparison with previous data acquired in fasted adult subjects. This suggests that up-regulation of the monocarboxylic acid transporter occurs with fasting. We report the measurement of D- beta -hydroxybutyrate (BHB) in the brains of six normal adult subjects during acute infusions of BHB. We used high field in vivo super(1)H magnetic resonance (MR) spectroscopy in the occipital lobe in conjunction with an acute infusion protocol to elevate plasma BHB levels from overnight fasted levels (0.20 plus or minus 0.10 mM) to a steady state value of 2.12 plus or minus 0.30 mM. At this level of hyperketonemia, we determined a tissue BHB level of 0.24 plus or minus 0.04 mM. No increases in brain lactate levels were seen in these data. The concentrations of BHB and lactate were both considerably lower in comparison with previous data acquired in fasted adult subjects. This suggests that up-regulation of the monocarboxylic acid transporter occurs with fasting. |
| Author | Stein, D. T. De Graaf, R. A. Hetherington, H. P. Pan, J. W. Lee, J. H. Rothman, D. L. Telang, F. W. |
| Author_xml | – sequence: 1 givenname: J. W. surname: Pan fullname: Pan, J. W. – sequence: 2 givenname: F. W. surname: Telang fullname: Telang, F. W. – sequence: 3 givenname: J. H. surname: Lee fullname: Lee, J. H. – sequence: 4 givenname: R. A. surname: De Graaf fullname: De Graaf, R. A. – sequence: 5 givenname: D. L. surname: Rothman fullname: Rothman, D. L. – sequence: 6 givenname: D. T. surname: Stein fullname: Stein, D. T. – sequence: 7 givenname: H. P. surname: Hetherington fullname: Hetherington, H. P. |
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| Cites_doi | 10.1152/ajplegacy.1973.224.6.1450 10.2337/diabetes.34.4.326 10.1111/j.1471-4159.1982.tb06644.x 10.1016/0009-8981(87)90366-4 10.1097/00004647-200010000-00012 10.1038/jcbfm.1994.17 10.1152/ajpendo.1986.250.2.E169 10.1042/bj1360531 10.1042/bj1220013 10.1152/ajpendo.1995.268.6.E1161 10.1042/bj1380001 10.1172/JCI105650 10.1002/1522-2594(200011)44:5<673::AID-MRM3>3.0.CO;2-L 10.2337/diab.43.11.1311 10.1152/ajplegacy.1975.229.5.1165 10.1152/ajpendo.1996.270.5.E746 10.1002/mrm.1910400305 10.1152/physrev.1980.60.1.143 |
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| References | 1973; 136 1973; 224 2000b; 44 1982; 38 1987; 167 2001 1986; 250 1974; 138 1994; 14 1996; 270 1995; 268 1967; 46 1980; 60 1971; 122 1985; 34 1998; 40 2000a; 20 1975; 229 1994; 43 e_1_2_7_6_1 e_1_2_7_4_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_12_1 e_1_2_7_11_1 e_1_2_7_10_1 Veneman T. (e_1_2_7_20_1) 1994; 43 Gjedde A. (e_1_2_7_5_1) 1975; 229 Barton R. N. (e_1_2_7_3_1) 1973; 136 |
| References_xml | – volume: 167 start-page: 135 year: 1987 end-page: 145 article-title: CSF: concentration and CSF/blood ratio of fuel related components in children after prolonged fasting publication-title: Clin. Chim. Acta – volume: 60 start-page: 143 year: 1980 end-page: 187 article-title: Physiological role of ketone bodies as substrates and signals in mammalian tissues publication-title: Physiol. Rev. – start-page: 1668. year: 2001 – volume: 138 start-page: 1 year: 1974 end-page: 10 article-title: Regulation of glucose and ketone body metabolism in brain of anesthetized rats publication-title: Biochem. J. – volume: 14 start-page: 125 year: 1994 end-page: 131 article-title: Brain metabolism during short term starvation in humans publication-title: J. Cereb. Blood Flow Metab. – volume: 34 start-page: 326 year: 1985 end-page: 332 article-title: Ketone body production and disposal in diabetic ketosis. a comparison with fasting ketosis publication-title: Diabetes – volume: 46 start-page: 1589 year: 1967 end-page: 1595 article-title: Brain metabolism during fasting publication-title: J. Clin. Invest. – volume: 122 start-page: 13 year: 1971 end-page: 18 article-title: Ketone body utilization by adult and suckling rat brain publication-title: Biochem. J. – volume: 20 start-page: 1502 year: 2000a end-page: 1507 article-title: Human brain β‐hydroxybutyrate and lactate increase in fasting induced ketosis publication-title: J. Cereb. Blood Flow Metab. – volume: 229 start-page: 1165 year: 1975 end-page: 1169 article-title: Induction processes in blood–brain transfer of ketone bodies during starvation publication-title: Am. J. Physiol. – volume: 250 start-page: E169 year: 1986 end-page: E178 article-title: Regional ketone body utilization by rat brain in starvation and diabetes publication-title: Am. J. Physiol. – volume: 268 start-page: E1161 year: 1995 end-page: E1166 article-title: Blood brain barrier permeability of glucose and ketone bodies during short‐term starvation in humans publication-title: Am. J. Physiol. – volume: 270 start-page: E746 year: 1996 end-page: E751 article-title: Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia publication-title: Am. J. Physiol. – volume: 40 start-page: 363 year: 1998 end-page: 369 article-title: Quantitative spectroscopic imaging of the human brain publication-title: Magn. Reson. Med. – volume: 44 start-page: 673 year: 2000b end-page: 679 article-title: Spectroscopic imaging of glutamate C4 turnover in human brain publication-title: Magn. Reson. Med. – volume: 43 start-page: 1311 year: 1994 end-page: 1317 article-title: Effect of hyperketonemia and hyperlacticacidemia on symptoms, cognitive dysfunction and counterregulatory hormone responses during hypoglycemia in normal humans publication-title: Diabetes – volume: 38 start-page: 1637 year: 1982 end-page: 1641 article-title: No effect of hyperketonemia on local cerebral glucose utilization in conscious rat publication-title: J. Neurochem. – volume: 136 start-page: 531 year: 1973 end-page: 543 article-title: The interconversion and disposal of ketone bodies in untreated and injured post‐absorptive rats publication-title: Biochem. J. – volume: 224 start-page: 1450 year: 1973 end-page: 1453 article-title: Carrier mediated blood brain barrier transport of short chain monocarboxylic organic acids publication-title: Am. J. Physiol. – ident: e_1_2_7_12_1 doi: 10.1152/ajplegacy.1973.224.6.1450 – ident: e_1_2_7_2_1 doi: 10.2337/diabetes.34.4.326 – ident: e_1_2_7_4_1 doi: 10.1111/j.1471-4159.1982.tb06644.x – ident: e_1_2_7_11_1 doi: 10.1016/0009-8981(87)90366-4 – ident: e_1_2_7_15_1 doi: 10.1097/00004647-200010000-00012 – ident: e_1_2_7_19_1 – ident: e_1_2_7_6_1 doi: 10.1038/jcbfm.1994.17 – ident: e_1_2_7_10_1 doi: 10.1152/ajpendo.1986.250.2.E169 – volume: 136 start-page: 531 year: 1973 ident: e_1_2_7_3_1 article-title: The interconversion and disposal of ketone bodies in untreated and injured post‐absorptive rats publication-title: Biochem. J. doi: 10.1042/bj1360531 contributor: fullname: Barton R. N. – ident: e_1_2_7_9_1 doi: 10.1042/bj1220013 – ident: e_1_2_7_7_1 doi: 10.1152/ajpendo.1995.268.6.E1161 – ident: e_1_2_7_18_1 doi: 10.1042/bj1380001 – ident: e_1_2_7_13_1 doi: 10.1172/JCI105650 – ident: e_1_2_7_16_1 doi: 10.1002/1522-2594(200011)44:5<673::AID-MRM3>3.0.CO;2-L – volume: 43 start-page: 1311 year: 1994 ident: e_1_2_7_20_1 article-title: Effect of hyperketonemia and hyperlacticacidemia on symptoms, cognitive dysfunction and counterregulatory hormone responses during hypoglycemia in normal humans publication-title: Diabetes doi: 10.2337/diab.43.11.1311 contributor: fullname: Veneman T. – volume: 229 start-page: 1165 year: 1975 ident: e_1_2_7_5_1 article-title: Induction processes in blood–brain transfer of ketone bodies during starvation publication-title: Am. J. Physiol. doi: 10.1152/ajplegacy.1975.229.5.1165 contributor: fullname: Gjedde A. – ident: e_1_2_7_8_1 doi: 10.1152/ajpendo.1996.270.5.E746 – ident: e_1_2_7_14_1 doi: 10.1002/mrm.1910400305 – ident: e_1_2_7_17_1 doi: 10.1152/physrev.1980.60.1.143 |
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| Snippet | We report the measurement of d‐β‐hydroxybutyrate (BHB) in the brains of six normal adult subjects during acute infusions of BHB. We used high field in vivo1H... We report the measurement of D-beta-hydroxybutyrate (BHB) in the brains of six normal adult subjects during acute infusions of BHB. We used high field in vivo... We report the measurement of d ‐β‐hydroxybutyrate (BHB) in the brains of six normal adult subjects during acute infusions of BHB. We used high field in vivo 1... We report the measurement of D- beta -hydroxybutyrate (BHB) in the brains of six normal adult subjects during acute infusions of BHB. We used high field in... |
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| SubjectTerms | 3-Hydroxybutyric Acid - pharmacokinetics Acute Disease Adult b-Hydroxybutyric acid Biochemistry and metabolism Biological and medical sciences Biological Transport - physiology brain Brain Chemistry - physiology Central nervous system Fasting - physiology Fundamental and applied biological sciences. Psychology Humans hyperketonemia Ketone Bodies - blood ketone body Ketosis - metabolism lactate Lactic Acid - blood Magnetic Resonance Spectroscopy Models, Biological monocarboxylate transporter Occipital Lobe - metabolism Protons Vertebrates: nervous system and sense organs β‐hydroxybutyrate |
| Title | Measurement of β‐hydroxybutyrate in acute hyperketonemia in human brain |
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