Role of ethanol-inducible cytochrome P-450 IIE1 in carbon tetrachloride-induced damage to centrilobular hepatocytes from ethanol-treated rats

The ethanol-inducible form of cytochrome P-450 (IIE1) is expressed and induced by ethanol, predominantly in the centrilobular region. Because this isoenzyme has a particularly high capacity to convert carbon tetrachloride and several other hepatotoxins into reactive intermediates, its role in produc...

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Bibliographic Details

Published in:	Hepatology (Baltimore, Md.) Vol. 12; no. 5; p. 1092
Main Authors:	Lindros, K O, Cai, Y A, Penttilä, K E
Format:	Journal Article
Language:	English
Published:	United States 01-11-1990
Subjects:	Animals Carbon Tetrachloride - pharmacology Cell Separation Cell Survival - drug effects Cells, Cultured Cimetidine - pharmacology Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - physiology Ethanol - pharmacology Isoniazid - pharmacology Liver - drug effects Liver - pathology Male Rats
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