Individualizing the use of [18F]FDG-PET/CT in patients with complicated Staphylococcus aureus bacteremia: experiences from a tertiary care center

• Published in: Infection Vol. 50; no. 2; pp. 491 - 498
• Main Authors: van Leerdam, Eline J., Gompelman, Michelle, Tuinte, Renée A. M., Aarntzen, Erik H. J. G., Berrevoets, Marvin A. H., Maat, Ianthe, Bleeker-Rovers, Chantal P., van Crevel, Reinout, ten Oever, Jaap, Kouijzer, Ilse J. E.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-04-2022; Springer Nature B.V
• Subjects: Adult; Antibiotics; Bacteremia; Bacteremia - drug therapy; Biomedical materials; Cardiovascular system; Cohort Studies; Computed tomography; Family Medicine; Fluorine isotopes; Fluorodeoxyglucose F18 - therapeutic use; General Practice; Grafting; Humans; Infections; Infectious Diseases; Internal Medicine; Medicine; Medicine & Public Health; Metastases; Metastasis; Original Paper; Orthopaedic implants; Orthopedics; Osteosynthesis; Patients; Positron emission; Positron emission tomography; Positron Emission Tomography Computed Tomography; Prostheses; Retrospective Studies; Rifampin; Staphylococcus aureus; Tertiary Care Centers; Tomography; Metastatic infection; F]FDG-PET/CT; Prolonged treatment; [; bacteremia; Staphylococcus aureus bacteremia; [18F]FDG-PET/CT
• ISSN: 0300-8126; 1439-0973
• DOI: 10.1007/s15010-021-01740-4

Purpose
[
18
F]FDG-PET/CT scanning can help detect metastatic infectious foci and reduce mortality in patients with
Staphylococcus aureus
bacteremia (SAB), but it is unknown if patients with SAB and an indication for prolonged treatment because of possible endovascular, orthopaedic implant, or other metastatic infection still need [
18
F]FDG-PET/CT.
Methods
In a retrospective single-center cohort study, we included all consecutive adult patients with SAB between 2013 and 2020 if an [
18
F]FDG-PET/CT scan was performed and antibiotic treatment was planned for ≥ 6 weeks prior to [
18
F]FDG-PET/CT. We aimed to identify patients for whom treatment was adjusted due to the results of [
18
F]FDG-PET/CT, and assessed concordance of [
18
F]FDG-PET/CT and clinical diagnosis for infected prosthetic material.
Results
Among 132 patients included, the original treatment plan was changed after [
18
F]FDG-PET/CT in 22 patients (16.7%), in the majority (
n
 = 20) due to diagnosing or rejecting endovascular (graft) infection. Antibiotic treatment modifications were shortening in 2, iv-oral switch in 3, extension in 13, and addition of rifampicin in 4 patients. Ninety additional metastatic foci based on [
18
F]FDG-PET/CT results were found in 69/132 patients (52.3%). [
18
F]FDG-PET/CT suggested vascular graft infection in 7/14 patients who lacked clinical signs of infection, but showed no infection of prosthetic joints or osteosynthesis material in eight patients who lacked clinical signs of such an infection.
Conclusion
[
18
F]FDG-PET/CT can help refine treatment for SAB in patients with clinically suspected endovascular infection or vascular grafts, even if 6 weeks treatment is already indicated, but can be safely omitted in other patients who are clinically stable.