Endoplasmic reticulum stress: Multiple regulatory roles in hepatocellular carcinoma
Endoplasmic reticulum (ER) stress is a basic cellular stress response that maintains cellular protein homeostasis under endogenous or exogenous stimuli, which depends on the stimulus, its intensity, and action time. The ER produces a corresponding cascade reaction for crosstalk of adaptive and/or pr...
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| Published in: | Biomedicine & pharmacotherapy Vol. 142; p. 112005 |
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| Abstract | Endoplasmic reticulum (ER) stress is a basic cellular stress response that maintains cellular protein homeostasis under endogenous or exogenous stimuli, which depends on the stimulus, its intensity, and action time. The ER produces a corresponding cascade reaction for crosstalk of adaptive and/or pro-death regulation with other organelles. Hepatocellular carcinoma(HCC) is one of the most common malignant solid tumors with an extremely poor prognosis. Viral hepatitis infection, cirrhosis, and steatohepatitis are closely related to the occurrence and development of HCC, and ER stress has gradually been shown to be a major mechanism. Moreover, an increasing need for protein and lipid products and relative deficiencies of oxygen and nutrients for rapid proliferation and endoplasmic reticulum stress are undoubtedly involved. Therefore, to fully and comprehensively understand the regulatory role of endoplasmic reticulum stress in the occurrence and progression of HCC is of vital importance to explore its pathogenesis and develop novel anti-cancer strategies.
We searched for relevant publications in the PubMed databases using the keywords “Endoplasmic reticulum stress”, “hepatocellular carcinoma” in last five years,and present an overview of the current knowledge that links ER stress and HCC, which includes carcinogenesis, progression, and anti-cancer strategies, and propose directions of future research.
ER stress were confirmed to be multiple regulators or effectors of cancer, which also be confirmed to drive tumorigenesis and progression of HCC. Targeting ER stress signaling pathway and related molecules could play a critical role for anti-HCC and has become a research hotspot for anti-cancer in recent years.
ER stress are critical for the processes of the tumorigenesis and progression of tumors. For HCC, ER stress was associated with tumorigenesis, development, metastasis, angiogenesis and drug resistance, targeting ER stress has emerged as a potential anti-tumor strategy. |
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| AbstractList | Endoplasmic reticulum (ER) stress is a basic cellular stress response that maintains cellular protein homeostasis under endogenous or exogenous stimuli, which depends on the stimulus, its intensity, and action time. The ER produces a corresponding cascade reaction for crosstalk of adaptive and/or pro-death regulation with other organelles. Hepatocellular carcinoma(HCC) is one of the most common malignant solid tumors with an extremely poor prognosis. Viral hepatitis infection, cirrhosis, and steatohepatitis are closely related to the occurrence and development of HCC, and ER stress has gradually been shown to be a major mechanism. Moreover, an increasing need for protein and lipid products and relative deficiencies of oxygen and nutrients for rapid proliferation and endoplasmic reticulum stress are undoubtedly involved. Therefore, to fully and comprehensively understand the regulatory role of endoplasmic reticulum stress in the occurrence and progression of HCC is of vital importance to explore its pathogenesis and develop novel anti-cancer strategies.
We searched for relevant publications in the PubMed databases using the keywords "Endoplasmic reticulum stress", "hepatocellular carcinoma" in last five years,and present an overview of the current knowledge that links ER stress and HCC, which includes carcinogenesis, progression, and anti-cancer strategies, and propose directions of future research.
ER stress were confirmed to be multiple regulators or effectors of cancer, which also be confirmed to drive tumorigenesis and progression of HCC. Targeting ER stress signaling pathway and related molecules could play a critical role for anti-HCC and has become a research hotspot for anti-cancer in recent years.
ER stress are critical for the processes of the tumorigenesis and progression of tumors. For HCC, ER stress was associated with tumorigenesis, development, metastasis, angiogenesis and drug resistance, targeting ER stress has emerged as a potential anti-tumor strategy. Background: Endoplasmic reticulum (ER) stress is a basic cellular stress response that maintains cellular protein homeostasis under endogenous or exogenous stimuli, which depends on the stimulus, its intensity, and action time. The ER produces a corresponding cascade reaction for crosstalk of adaptive and/or pro-death regulation with other organelles. Hepatocellular carcinoma(HCC) is one of the most common malignant solid tumors with an extremely poor prognosis. Viral hepatitis infection, cirrhosis, and steatohepatitis are closely related to the occurrence and development of HCC, and ER stress has gradually been shown to be a major mechanism. Moreover, an increasing need for protein and lipid products and relative deficiencies of oxygen and nutrients for rapid proliferation and endoplasmic reticulum stress are undoubtedly involved. Therefore, to fully and comprehensively understand the regulatory role of endoplasmic reticulum stress in the occurrence and progression of HCC is of vital importance to explore its pathogenesis and develop novel anti-cancer strategies. Methodology: We searched for relevant publications in the PubMed databases using the keywords “Endoplasmic reticulum stress”, “hepatocellular carcinoma” in last five years,and present an overview of the current knowledge that links ER stress and HCC, which includes carcinogenesis, progression, and anti-cancer strategies, and propose directions of future research. Result: ER stress were confirmed to be multiple regulators or effectors of cancer, which also be confirmed to drive tumorigenesis and progression of HCC. Targeting ER stress signaling pathway and related molecules could play a critical role for anti-HCC and has become a research hotspot for anti-cancer in recent years. Conclusion: ER stress are critical for the processes of the tumorigenesis and progression of tumors. For HCC, ER stress was associated with tumorigenesis, development, metastasis, angiogenesis and drug resistance, targeting ER stress has emerged as a potential anti-tumor strategy. |
| ArticleNumber | 112005 |
| Author | Xiang, Yien Wu, Jiacheng Cui, Menying Zhang, Xuewen Yao, Xiaoxiao Lin, Ruixin Qiao, Shan |
| Author_xml | – sequence: 1 givenname: Jiacheng surname: Wu fullname: Wu, Jiacheng email: wujiacheng2005@jlu.edu.cn organization: Department of Hepatobiliary and Pancreatic Surgery, Second Hospital of Jilin University, Changchun 130041, China – sequence: 2 givenname: Shan surname: Qiao fullname: Qiao, Shan email: qiaoshan@jlu.edu.cn organization: Department of Neurosurgery, First Hospital of Jilin University, Changchun 130021, China – sequence: 3 givenname: Yien surname: Xiang fullname: Xiang, Yien email: xiangye17@mails.jlu.edu.cn organization: Department of Hepatobiliary and Pancreatic Surgery, Second Hospital of Jilin University, Changchun 130041, China – sequence: 4 givenname: Menying surname: Cui fullname: Cui, Menying email: cuimy17@mails.jlu.edu.cn organization: Department of Hepatobiliary and Pancreatic Surgery, Second Hospital of Jilin University, Changchun 130041, China – sequence: 5 givenname: Xiaoxiao surname: Yao fullname: Yao, Xiaoxiao email: yaoxx@jlu.edu.cn organization: Department of Hepatobiliary and Pancreatic Surgery, Second Hospital of Jilin University, Changchun 130041, China – sequence: 6 givenname: Ruixin surname: Lin fullname: Lin, Ruixin email: linrx@mails.jlu.edu.cn organization: Department of Hepatobiliary and Pancreatic Surgery, Second Hospital of Jilin University, Changchun 130041, China – sequence: 7 givenname: Xuewen surname: Zhang fullname: Zhang, Xuewen email: zhangxw@jlu.edu.cn organization: Department of Hepatobiliary and Pancreatic Surgery, Second Hospital of Jilin University, Changchun 130041, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34426262$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1155_2022_8284500 crossref_primary_10_3390_medicina58121803 crossref_primary_10_3390_cancers14184524 crossref_primary_10_3390_cells11233870 crossref_primary_10_1038_s41598_023_35031_9 crossref_primary_10_1002_cam4_5874 crossref_primary_10_3389_fphar_2022_909123 crossref_primary_10_3390_ph16020234 crossref_primary_10_3390_cells11050815 crossref_primary_10_3934_mbe_2023188 crossref_primary_10_1002_ddr_22024 crossref_primary_10_1016_j_freeradbiomed_2024_04_235 crossref_primary_10_1186_s13765_022_00759_x crossref_primary_10_3390_v14122630 crossref_primary_10_32604_biocell_2022_025468 crossref_primary_10_3389_fgene_2022_965100 crossref_primary_10_1016_j_cbi_2023_110785 crossref_primary_10_12677_WJCR_2023_132005 crossref_primary_10_3390_biomedicines11041166 crossref_primary_10_1007_s13577_021_00657_2 crossref_primary_10_1038_s41598_023_49987_1 crossref_primary_10_1016_j_ajpath_2022_09_012 crossref_primary_10_1097_WNR_0000000000001853 crossref_primary_10_1016_j_ajpath_2023_03_009 crossref_primary_10_18632_aging_204983 crossref_primary_10_1016_S1875_5364_23_60403_0 crossref_primary_10_3390_toxics11020167 crossref_primary_10_1016_j_jconrel_2023_01_051 |
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| Keywords | UPR, Anti-cancer therapy Hepatocellular carcinoma Endoplasmic reticulum stress |
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| SubjectTerms | Animals Carcinogenesis - pathology Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy Disease Progression Drug Resistance, Neoplasm Endoplasmic reticulum stress Endoplasmic Reticulum Stress - physiology Hepatocellular carcinoma Humans Liver Neoplasms - pathology Liver Neoplasms - therapy Signal Transduction - physiology UPR, Anti-cancer therapy |
| Title | Endoplasmic reticulum stress: Multiple regulatory roles in hepatocellular carcinoma |
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