Spread of multidrug-resistant Acinetobacter baumannii isolates belonging to IC1 and IC5 major clones in Rondônia state
In Brazil, carbapenem-resistant A. baumannii (CRAB) is a critical pathogen showing high carbapenem resistance rates. Currently, there is little epidemiological data on A. baumannii isolated in the Northern Brazilian region. Herein, this study aimed to characterize the resistance mechanisms of CRAB i...
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| Published in: | Brazilian journal of microbiology Vol. 53; no. 2; pp. 795 - 799 |
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| Main Authors: | , , , , , , , , , , |
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| Language: | English |
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01-06-2022
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| Abstract | In Brazil, carbapenem-resistant
A. baumannii
(CRAB) is a critical pathogen showing high carbapenem resistance rates. Currently, there is little epidemiological data on
A. baumannii
isolated in the Northern Brazilian region. Herein, this study aimed to characterize the resistance mechanisms of CRAB isolates recovered from hospitalized patients in the state of Rondônia in 2019. Most of CRAB were considered as extensively drug-resistant, and some of them showed high MICs for minocycline. Only polymyxins showed a satisfactory activity. All isolates carried
bla
OXA-23
and were included in 14 distinct clusters, with the predominance of clonal group A (29%). The IC1 was the most frequent clonal group, followed by IC5 and IC4. Here, we firstly reported the epidemiological scenario of CRAB in the state of Rondônia, located in the Brazilian Amazon region. The high frequency of CRAB presenting XDR phenotype is of great concern, due to limited therapeutical options, especially in the actual pandemic scenario, in which we observed an overcrowding of ICU beds. Such results are essential to better characterize the epidemiology of CRAB in the entire Brazilian territory. |
|---|---|
| AbstractList | In Brazil, carbapenem-resistant
A. baumannii
(CRAB) is a critical pathogen showing high carbapenem resistance rates. Currently, there is little epidemiological data on
A. baumannii
isolated in the Northern Brazilian region. Herein, this study aimed to characterize the resistance mechanisms of CRAB isolates recovered from hospitalized patients in the state of Rondônia in 2019. Most of CRAB were considered as extensively drug-resistant, and some of them showed high MICs for minocycline. Only polymyxins showed a satisfactory activity. All isolates carried
bla
OXA-23
and were included in 14 distinct clusters, with the predominance of clonal group A (29%). The IC1 was the most frequent clonal group, followed by IC5 and IC4. Here, we firstly reported the epidemiological scenario of CRAB in the state of Rondônia, located in the Brazilian Amazon region. The high frequency of CRAB presenting XDR phenotype is of great concern, due to limited therapeutical options, especially in the actual pandemic scenario, in which we observed an overcrowding of ICU beds. Such results are essential to better characterize the epidemiology of CRAB in the entire Brazilian territory. In Brazil, carbapenem-resistant A. baumannii (CRAB) is a critical pathogen showing high carbapenem resistance rates. Currently, there is little epidemiological data on A. baumannii isolated in the Northern Brazilian region. Herein, this study aimed to characterize the resistance mechanisms of CRAB isolates recovered from hospitalized patients in the state of Rondônia in 2019. Most of CRAB were considered as extensively drug-resistant, and some of them showed high MICs for minocycline. Only polymyxins showed a satisfactory activity. All isolates carried blaOXA-23 and were included in 14 distinct clusters, with the predominance of clonal group A (29%). The IC1 was the most frequent clonal group, followed by IC5 and IC4. Here, we firstly reported the epidemiological scenario of CRAB in the state of Rondônia, located in the Brazilian Amazon region. The high frequency of CRAB presenting XDR phenotype is of great concern, due to limited therapeutical options, especially in the actual pandemic scenario, in which we observed an overcrowding of ICU beds. Such results are essential to better characterize the epidemiology of CRAB in the entire Brazilian territory. In Brazil, carbapenem-resistant A. baumannii (CRAB) is a critical pathogen showing high carbapenem resistance rates. Currently, there is little epidemiological data on A. baumannii isolated in the Northern Brazilian region. Herein, this study aimed to characterize the resistance mechanisms of CRAB isolates recovered from hospitalized patients in the state of Rondônia in 2019. Most of CRAB were considered as extensively drug-resistant, and some of them showed high MICs for minocycline. Only polymyxins showed a satisfactory activity. All isolates carried bla and were included in 14 distinct clusters, with the predominance of clonal group A (29%). The IC1 was the most frequent clonal group, followed by IC5 and IC4. Here, we firstly reported the epidemiological scenario of CRAB in the state of Rondônia, located in the Brazilian Amazon region. The high frequency of CRAB presenting XDR phenotype is of great concern, due to limited therapeutical options, especially in the actual pandemic scenario, in which we observed an overcrowding of ICU beds. Such results are essential to better characterize the epidemiology of CRAB in the entire Brazilian territory. |
| Author | da Silva, Juliana Thalita Paulino Barcelos Valiatti, Tiago Moura, Lorena Brandhuber Cayô, Rodrigo da Silva, Cicileia Correia Silva Carvalho, Tatiane Ferreira, Jacqueline Andrade Fernandes Santos, Fernanda Silva Nodari, Carolina dos Santos, Levy Assis Gales, Ana Cristina |
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| Keywords | Carbapenemase Northern region spp Non-fermenter bacilli International clones Acinetobacter spp |
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| Snippet | In Brazil, carbapenem-resistant
A. baumannii
(CRAB) is a critical pathogen showing high carbapenem resistance rates. Currently, there is little epidemiological... In Brazil, carbapenem-resistant A. baumannii (CRAB) is a critical pathogen showing high carbapenem resistance rates. Currently, there is little epidemiological... |
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| SubjectTerms | Acinetobacter baumannii - genetics Acinetobacter Infections - epidemiology Acinetobacter Infections - microbiology Anti-Bacterial Agents - pharmacology Antibiotics Bacterial Proteins - genetics beta-Lactamases - genetics Biomedical and Life Sciences Carbapenems Clinical Microbiology - Short Communication Clone Cells Drug Resistance, Multiple, Bacterial - genetics Epidemiology Food Microbiology Humans Life Sciences Medical Microbiology Microbial Ecology Microbial Genetics and Genomics Microbial Sensitivity Tests Microbiology Minocycline Multidrug resistance Multidrug resistant organisms Mycology Overcrowding Phenotypes Polymyxins |
| Title | Spread of multidrug-resistant Acinetobacter baumannii isolates belonging to IC1 and IC5 major clones in Rondônia state |
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