Synergistic Effects of a Mixture of Glycosaminoglycans to Inhibit Adipogenesis and Enhance Chondrocyte Features in Multipotent Cells

Background/Aims: Multipotent mesenchymal stem cells affect homeostasis of adipose and joint tissues. Factors influencing their differentiation fate are of interest for both obesity and joint problems. We studied the impact of a mixture of glycosaminoglycans (GAGs) (hyaluronic acid: dermatan sulfate...

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Bibliographic Details
Published in:	Cellular physiology and biochemistry Vol. 37; no. 5; pp. 1792 - 1806
Main Authors:	Petrov, Petar D., Granados, Nuria, Chetrit, Carles, Martínez-Puig, Daniel, Palou, Andreu, Bonet, M. Luisa
Format:	Journal Article
Language:	English
Published:	Basel, Switzerland Cell Physiol Biochem Press GmbH & Co KG 01-11-2015
Subjects:	Adipocytes - cytology Adipocytes - metabolism Adipogenesis Adipogenesis - drug effects Adipokines - genetics Adipokines - metabolism Aggrecans - genetics Aggrecans - metabolism Animals Bone Morphogenetic Protein 2 - pharmacology Cells, Cultured Chondrocytes - metabolism Chondrogenesis Decorin - genetics Decorin - metabolism Dermatan Sulfate - pharmacology Down-Regulation - drug effects Drug Synergism Embryo, Mammalian - cytology Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Glycosaminoglycans Glycosaminoglycans - pharmacology Hyaluronic Acid - pharmacology Joint health Mice Obesity Original Paper Osteoarthritis Up-Regulation - drug effects Obesity Glycosaminoglycans Chondrogenesis Osteoarthritis Joint health Adipogenesis
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