Recovery of post-stroke cognitive and motor deficiencies by Shuxuening injection via regulating hippocampal BDNF-mediated Neurotrophin/Trk Signaling

A mild ischemic stroke may cause both debilitating locomotor and cognitive decline, for which the mechanism is not fully understood, and no therapies are currently available. In this study, a nonfatal stroke model was constructed in mice by a modified middle cerebral artery occlusion (MCAO) procedur...

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Bibliographic Details
Published in:	Biomedicine & pharmacotherapy Vol. 141; p. 111828
Main Authors:	Li, Zhixiong, Wang, Huanyi, Xiao, Guangxu, Du, Hongxia, He, Shuang, Feng, Yuxin, Zhang, Boli, Zhu, Yan
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-09-2021 Elsevier
Subjects:	Animals Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - drug effects Cell Line Cognition Disorders - drug therapy Cognition Disorders - etiology Cognitive dysfunction Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - therapeutic use Gene Expression Regulation - drug effects Hippocampus - metabolism Ischemic stroke Male Mice Mice, Inbred C57BL Movement Disorders - drug therapy Movement Disorders - etiology Nerve Growth Factors - drug effects Neurotrophin/Trk Signaling Psychomotor Performance - drug effects Receptor, trkA - drug effects Recovery of Function Shuxuening injection Signal Transduction - drug effects Stroke - complications Stroke - psychology Stroke Rehabilitation - methods Transcriptome CIRI TTC Mek3 SXNI rBCF PPI CNS GBE WB Ischemic stroke Creb DEGs mNSS OGD/R FBS RT-PCR IF p-Erk Cognitive dysfunction MCAO Shuxuening injection MWM AD BDNF H&E Neurotrophin/Trk Signaling GFAP Ngfr p75 PA TrkB Brain-derived neurotrophic factor PD IPA HD ELISA TCM
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