Cutaneous features of myotonic dystrophy types 1 and 2: Implication of premature aging and vitamin D homeostasis

• Published in: Neuromuscular disorders : NMD Vol. 27; no. 2; pp. 163 - 169
• Main Authors: Campione, Elena, MD, PhD, Botta, Annalisa, PhD, Di Prete, Monia, MD, Rastelli, Emanuele, MD, Gibellini, Manuela, MD, Petrucci, Antonio, MD, Bernardini, Sergio, MD, Novelli, Giuseppe, PhD, Bianchi, Luca, MD, Orlandi, Augusto, MD, Massa, Roberto, MD, Terracciano, Chiara, MD, PhD
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01-02-2017
• Subjects: Adult; Aged; Aged, 80 and over; Aging, Premature - pathology; Homeostasis - physiology; Humans; Middle Aged; Myotonic Dystrophy - blood; Myotonic Dystrophy - complications; Myotonic Dystrophy - pathology; Myotonic dystrophy type 1; Myotonic dystrophy type 2; Neurology; Nevus - etiology; Nevus - pathology; Premature aging; Skin - pathology; Skin abnormalities; Skin Neoplasms - etiology; Skin Neoplasms - pathology; Vitamin D; Vitamin D - blood; Young Adult; Myotonic dystrophy type 1; Skin abnormalities; Premature aging; Vitamin D; Myotonic dystrophy type 2
• ISSN: 0960-8966; 1873-2364
• DOI: 10.1016/j.nmd.2016.11.004

Highlights • DM1 and DM2 display a high frequency and a similar pattern of cutaneous alterations • Nevi abnormalities and premature aging are the most common skin features in DM • In DM1 patients, the number of nevi correlated with CTG expansion size • Dysplastic nevi and xerosis inversely correlated with vitamin D levels in DM1