The Landmark Series: Management of Small Bowel Neuroendocrine Tumors

Surgical resection is the foundation for treatment of small bowel neuroendocrine tumors (SBNETs). Guidelines for surgical management of SBNETs rely on retrospective data, which suggest that primary tumor resection and cytoreduction improve symptoms, prevent future complications, and lengthen surviva...

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Bibliographic Details
Published in:	Annals of surgical oncology Vol. 28; no. 5; pp. 2741 - 2751
Main Authors:	Tran, Catherine G., Sherman, Scott K., Howe, James R.
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-05-2021 Springer Nature B.V
Subjects:	Endocrine Tumors Humans Intestinal Neoplasms - therapy Intestine, Small Medical treatment Medicine Medicine & Public Health Neuroendocrine tumors Neuroendocrine Tumors - therapy Oncology Pancreatic Neoplasms Radiation therapy Retrospective Studies Small intestine Somatostatin Surgery Surgical Oncology Survival
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Summary:	Surgical resection is the foundation for treatment of small bowel neuroendocrine tumors (SBNETs). Guidelines for surgical management of SBNETs rely on retrospective data, which suggest that primary tumor resection and cytoreduction improve symptoms, prevent future complications, and lengthen survival. In advanced NETs, improvement in progression-free survival has been reported in large, randomized, controlled trials of various medical treatments, including somatostatin analogues, targeted therapy, and peptide receptor radionuclide therapy. This review discusses important studies influencing the management of SBNETs and the limitations of current evidence regarding surgical interventions for SBNETs.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1068-9265 1534-4681
DOI:	10.1245/s10434-020-09566-4