Effect of Metaswitch® dietary supplement on anthropometric parameters, serum lipids, glucose level, oxidative stress and in vivo antioxidant properties in high fat diet-induced overweight Sprague Dawley rats

• Published in: Biomedicine & pharmacotherapy Vol. 149; p. 112892
• Main Authors: N’guessan, Benoit Banga, Twumasi-Ankrah, Jessica Sarpongmaa, Amponsah, Seth Kwabena, Adams, Ismaila, Poakwah, Albert Kyei-Kankam, Brown, Charles, Adinortey, Michael Buenor, Sarkodie, Joseph Adusei, Adi-Dako, Ofosua, Asiedu-Gyekye, Isaac Julius, Appiah-Opong, Regina
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01-05-2022; Elsevier
• Subjects: Animals; Antioxidant systems; Antioxidants - metabolism; Antioxidants - pharmacology; Body Weight; Cyproheptadine - pharmacology; Diet, High-Fat - adverse effects; Dietary supplement; Dietary Supplements; Female; Glucose - pharmacology; Metaswitch; Noncommunicable Diseases; Overweight; Overweight - drug therapy; Oxidative Stress; Rats; Rats, Sprague-Dawley; Serum lipids; Sprague Dawley; Weight Gain; Weight-loss; Serum lipids; Oxidative stress; Dietary supplement; Sprague Dawley; Weight-loss; Metaswitch; Overweight; Antioxidant systems
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2022.112892

Obesity and overweight are metabolic disorders associated with oxidative stress, and risk factors for many chronic diseases. We sought to investigate the effects of Metaswitch dietary supplement on weight gain and associated acute metabolic alterations in a high-fat diet-induced overweight rat model.
Female Sprague Dawley (SD) rats were put into 6 groups. Control groups were fed normal (NCD) or high-fat diet (HFD). Treatment groups on HFD receieved 3 different daily doses of Metaswitch for 3 weeks. Another group on HFD received Slimrite® (phenylpropanolamine), a standard drug. Rats on HFD also received cyproheptadine to stimulate appetite. Food consumption and anthropometric parameters were determined weekly. Serum lipids, glucose level, hepatic lipid peroxidation, and antioxidant activity were used to assess overweight in rats.
Food intake remained relatively constant among groups. Rats on HFD had significantly increased body weight compared to rats fed NCD. Metaswitch significantly prevented weight gain; this effect was greater or similar to rats administered Slimrite, but was not dose-dependant. No significant changes occurred in the levels of serum lipids and glucose among the groups. However, serum triglyceride (TG) was significantly increased. The TG/HDL-C ratio revealed significant metabolic alterations which was prevented by Metaswitch. Catalase activity was significantly decreased in the HFD untreated group but was restored in Metaswitch-treated groups.
A 3-week HFD regimen with cyproheptadine supplementation in female SD rats resulted in a significant increase in body weight and acute metabolic alterations. The aforementioned changes were found to have been prevented with the administration of Metaswitch.
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•A 3-week HFD regimen with cyproheptadine increased body weight of female rats.•Levels of serum lipids, oxidative stress and antioxidant enzymes were unchanged.•The triglyceride to HDL-C ratio revealed early metabolic dysfunction.•Metaswitch prevented anthropometric and early serum and liver metabolic changes.•Metaswitch exhibited dose-independent effects greater than or similar to Slimrite.