Antibacterial and antibiofilm potential of silver nanoparticles against antibiotic-sensitive and multidrug-resistant Pseudomonas aeruginosa strains

• Published in: Brazilian journal of microbiology Vol. 52; no. 1; pp. 267 - 278
• Main Authors: de Lacerda Coriolano, Davi, de Souza, Jaqueline Barbosa, Bueno, Elias Vicente, Medeiros, Sandrelli Meridiana de Fátima Ramos dos Santos, Cavalcanti, Iago Dillion Lima, Cavalcanti, Isabella Macário Ferro
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-03-2021; Springer Nature B.V
• Subjects: Antibiotics; Antimicrobial activity; Antimicrobial agents; Bacteria; Biofilms; Biomedical and Life Sciences; Biomolecules; Biotechnology and Industrial Microbiology - Review; Cell walls; Cellular structure; Cytoplasmic membranes; Disruption; Food Microbiology; Free radicals; Gram-negative bacteria; Life Sciences; Literature reviews; Medical Microbiology; Microbial Ecology; Microbial Genetics and Genomics; Microbiology; Microorganisms; Minimum inhibitory concentration; Multidrug resistance; Multidrug resistant organisms; Mycology; Nanoparticles; Oxidative stress; Pseudomonas aeruginosa; Reactive oxygen species; Silver; Strains (organisms); AgNPs; Biofilm; Antibacterial activity; Antibiofilm activity; Multidrug-resistant bacteria; Pseudomonas aeruginosa
• ISSN: 1517-8382; 1678-4405
• DOI: 10.1007/s42770-020-00406-x

Due to the severity of infections caused by
P. aeruginosa
and the limitations in treatment, it is necessary to find new therapeutic alternatives. Thus, the use of silver nanoparticles (AgNPs) is a viable alternative because of their potential actions in the combat of microorganisms, showing efficacy against Gram-positive and Gram-negative bacteria, including multidrug-resistant microorganisms (MDR). In this sense, the aim of this work was to conduct a literature review related to the antibacterial and antibiofilm activity of AgNPs against antibiotic-sensitive and multidrug-resistant
Pseudomonas aeruginosa
strains. The AgNPs are promising for future applications, which may match the clinical need for effective antibiotic therapy. The size of AgNPs is a crucial element to determine the therapeutic activity of nanoparticles, since smaller particles present a larger surface area of contact with the microorganism, affecting their vital functioning. AgNPs adhere to the cytoplasmic membrane and cell wall of microorganisms, causing disruption, penetrating the cell, interacting with cellular structures and biomolecules, and inducing the generation of reactive oxygen species and free radicals. Studies describe the antimicrobial activity of AgNPs at minimum inhibitory concentration (MIC) between 1 and 200 μg/mL against susceptible and MDR
P. aeruginosa
strains. These studies have also shown antibiofilm activity through disruption of biofilm structure, and oxidative stress, inhibiting biofilm growth at concentrations between 1 and 600 μg/mL of AgNPs. This study evidences the advance of AgNPs as an antibacterial and antibiofilm agent against
Pseudomonas aeruginosa
strains, demonstrating to be an extremely promising approach to the development of new antimicrobial systems.