Photoacoustic Imaging-Guided Photothermal Therapy with Tumor-Targeting HA-FeOOH@PPy Nanorods

• Published in: Scientific reports Vol. 8; no. 1; pp. 8809 - 13
• Main Authors: Phan, Thi Tuong Vy, Bui, Nhat Quang, Cho, Soon-Woo, Bharathiraja, Subramaniyan, Manivasagan, Panchanathan, Moorthy, Madhappan Santha, Mondal, Sudip, Kim, Chang-Seok, Oh, Junghwan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11-06-2018; Nature Publishing Group
• Subjects: 14/28; 140/125; 59/5; 631/61/350/354; 631/67/1347; 64/60; 96/2; 96/34; Antitumor activity; Cancer; Cancer therapies; Humanities and Social Sciences; Hyaluronic acid; I.R. radiation; multidisciplinary; Nanoparticles; Nanotechnology; Polypyrroles; Science; Science (multidisciplinary); Tumors
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-27204-8

Cancer theragnosis agents with both cancer diagnosis and therapy abilities would be the next generation of cancer treatment. Recently, nanomaterials with strong absorption in near-infrared (NIR) region have been explored as promising cancer theragnosis agents for bio-imaging and photothermal therapy (PTT). Herein, we reported the synthesis and application of a novel multifunctional theranostic nanoagent based on hyaluronan (HA)-coated FeOOH@polypyrrole (FeOOH@PPy) nanorods (HA-FeOOH@PPy NRs) for photoacoustic imaging (PAI)-guided PTT. The nanoparticles were intentionally designed with rod-like shape and conjugated with tumor-targeting ligands to enhance the accumulation and achieve the entire tumor distribution of nanoparticles. The prepared HA-FeOOH@PPy NRs showed excellent biocompatible and physiological stabilities in different media. Importantly, HA-FeOOH@PPy NRs exhibited strong NIR absorbance, remarkable photothermal conversion capability, and conversion stability. Furthermore, HA-FeOOH@PPy NRs could act as strong contrast agents to enhance PAI, conducting accurate locating of cancerous tissue, as well as precise guidance for PTT. The
in vitro
and
in vivo
photothermal anticancer activity results of the designed nanoparticles evidenced their promising potential in cancer treatment. The tumor-bearing mice completely recovered after 17 days of PTT treatment without obvious side effects. Thus, our work highlights the great potential of using HA-FeOOH@PPy NRs as a theranostic nanoplatform for cancer imaging-guided therapy.