Diuretic, laxative and toxicity studies of Cocculus hirsutus aerial parts

• Published in: Fitoterapia Vol. 73; no. 1; pp. 28 - 31
• Main Authors: Ganapaty, S., Dash, G.K., Subburaju, T., Suresh, P.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01-02-2002; Elsevier
• Subjects: Animals; Biological and medical sciences; Cathartics - administration & dosage; Cathartics - pharmacology; Cathartics - therapeutic use; Cocculus hirsutus; Constipation - drug therapy; Diarrhea - drug therapy; Diuresis - drug effects; Diuretic activity; Diuretics - administration & dosage; Diuretics - pharmacology; Diuretics - therapeutic use; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility - drug effects; General pharmacology; Laxative activity; Male; Medical sciences; Menispermaceae; Mice; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plant Structures; Rats; Rats, Wistar; Asia; India; Diuretic activity; Laxative activity; Cocculus hirsutus; Rat; Pharmacognosy; Toxicity; Rodentia; Oral administration; Extract; Laxative; Menispermaceae; Biological activity; Medicinal plant; Diuretic; Vertebrata; Mammalia; Folk medicine; Mouse; Dicotyledones; Animal; Angiospermae; Plant origin; Above ground plant part; Spermatophyta
• ISSN: 0367-326X
• DOI: 10.1016/S0367-326X(01)00345-8

The aqueous extract of the
Cocculus hirsutus aerial parts (100 and 200 mg/kg, p.o.) showed significant diuretic activity and laxative effect in rats. The acute toxicity, orally evaluated in mice, was found to be higher than 3000 mg/kg.