MDR reversal and pro-apoptotic effects of statins and statins combined with flavonoids in colon cancer cells

[Display omitted] •Simvastatin and mevastatin inhibit proliferation of LoVo and LoVo/Dx cancer cells.•Antiproliferative effect is accompanied by apoptosis induction.•Studied statins are MDR-reversing agents in resistant cancer cells LoVo/Dx.•Some flavonoids increase the cytotoxic and pro-apoptotic e...

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Bibliographic Details
Published in:	Biomedicine & pharmacotherapy Vol. 109; pp. 1511 - 1522
Main Authors:	Palko-Łabuz, Anna, Środa-Pomianek, Kamila, Wesołowska, Olga, Kostrzewa-Susłow, Edyta, Uryga, Anna, Michalak, Krystyna
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-01-2019 Elsevier
Subjects:	Apoptosis Cytotoxicity Flavonoids HMG-CoA reductase Multidrug resistance P-glycoprotein Statins ABC SRB PCNA DMSO HRP Cytotoxicity Mdr1 HMG-CoA reductase IC50 MDR Statins AEC BCRP PBS β-GUS MRP1 P-gp Multidrug resistance HMG-CoA DEPC P-glycoprotein Flavonoids DEVD-pNA PCR Apoptosis
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