Phase 1 study of mTORC1/2 inhibitor sapanisertib (TAK-228) in advanced solid tumours, with an expansion phase in renal, endometrial or bladder cancer

Background This Phase 1 dose-escalation/expansion study assessed safety/tolerability of sapanisertib, an oral, highly selective inhibitor of mTORC1/mTORC2, in advanced solid tumours. Methods Eligible patients received increasing sapanisertib doses once daily (QD; 31 patients), once weekly (QW; 30 pa...

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Bibliographic Details
Published in:	British journal of cancer Vol. 123; no. 11; pp. 1590 - 1598
Main Authors:	Voss, Martin H., Gordon, Michael S., Mita, Monica, Rini, Brian, Makker, Vicky, Macarulla, Teresa, Smith, David C., Cervantes, Andrés, Puzanov, Igor, Pili, Roberto, Wang, Ding, Jalal, Shadia, Pant, Shubham, Patel, Manish R., Neuwirth, Rachel l., Enke, Aaron, Shou, Yaping, Sedarati, Farhad, Faller, Douglas V., Burris, Howard A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 24-11-2020 Nature Publishing Group
Subjects:	692/4028/67/1059 692/4028/67/1517 692/4028/67/589 Adult Aged Aged, 80 and over Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Asthenia Biomedical and Life Sciences Biomedicine Bladder cancer Cancer Research Carcinoma, Renal Cell - drug therapy Dosage Drug Resistance Endometrial cancer Endometrial Neoplasms - drug therapy Endometrium Epidemiology Female Humans Hyperglycemia Kidney cancer Kidney Neoplasms - drug therapy Male Maximum Tolerated Dose Middle Aged Molecular Medicine Neoplasms - drug therapy Oncology Patients Pharmacodynamics Pharmacokinetics Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - pharmacokinetics Pyrazoles - administration & dosage Pyrazoles - adverse effects Pyrazoles - pharmacokinetics Pyrimidines - administration & dosage Pyrimidines - adverse effects Pyrimidines - pharmacokinetics Renal cell carcinoma Solid tumors Stomatitis TOR Serine-Threonine Kinases - antagonists & inhibitors Tumors Urinary Bladder Neoplasms - drug therapy
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