Misidentification of the SARS-CoV-2 Mu variant using commercial mutation screening assays
Detection of mutations by multiplex real-time RT-PCR is a widely used method for the screening of SARS-CoV-2 variants, but this method has several limitations. We describe three cases in which a Mu strain containing the mutation K417N was initially misclassified as the Beta variant. We recommend the...
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| Published in: | Archives of virology Vol. 167; no. 4; pp. 1141 - 1144 |
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| Main Authors: | , , , , , |
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01-04-2022
Springer Nature B.V |
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| Abstract | Detection of mutations by multiplex real-time RT-PCR is a widely used method for the screening of SARS-CoV-2 variants, but this method has several limitations. We describe three cases in which a Mu strain containing the mutation K417N was initially misclassified as the Beta variant. We recommend the detection of P681H to distinguish between these two variants. Our experience highlights the importance of keeping track of new variants and mutations in order to adapt the current workflows. |
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| AbstractList | Detection of mutations by multiplex real-time RT-PCR is a widely used method for the screening of SARS-CoV-2 variants, but this method has several limitations. We describe three cases in which a Mu strain containing the mutation K417N was initially misclassified as the Beta variant. We recommend the detection of P681H to distinguish between these two variants. Our experience highlights the importance of keeping track of new variants and mutations in order to adapt the current workflows. Detection of mutations by multiplex real-time RT-PCR is a widely used method for the screening of SARS-CoV-2 variants, but this method has several limitations. We describe three cases in which a Mu strain containing the mutation K417N was initially misclassified as the Beta variant. We recommend the detection of P681H to distinguish between these two variants. Our experience highlights the importance of keeping track of new variants and mutations in order to adapt the current workflows. |
| Author | Gual-de-Torrella, Ana Gallego, Mikel López de Goikoetxea, Maria José Lejarraga, Clara Urrutikoetxea-Gutierrez, Mikel Alejo-Cancho, Izaskun |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35194675$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_pathogens11091058 crossref_primary_10_1016_j_eimce_2022_10_010 crossref_primary_10_1038_s41598_023_28715_9 crossref_primary_10_1016_j_eimc_2022_04_004 crossref_primary_10_3389_fbioe_2022_1052436 |
| Cites_doi | 10.1016/J.WATRES.2021.117104 10.1016/J.CELL.2021.09.003 10.1016/J.JCV.2021.104903 10.1128/JCM.00859-21/SUPPL_FILE/JCM.00859-21-S0001.PDF 10.1038/s41586-020-2012-7 10.1016/J.JCV.2021.104905 10.1038/s41576-021-00408-x 10.3389/fcimb.2021.672562 |
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| SubjectTerms | Biomedical and Life Sciences Biomedicine Brief Report COVID-19 - diagnosis Humans Infectious Diseases Medical Microbiology Multiplex Polymerase Chain Reaction Mutation Polymerase chain reaction SARS-CoV-2 - genetics Severe acute respiratory syndrome coronavirus 2 Virology |
| Title | Misidentification of the SARS-CoV-2 Mu variant using commercial mutation screening assays |
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