Amelioration of obesity-related biomarkers by Lactobacillus sakei CJLS03 in a high-fat diet-induced obese murine model

• Published in: Scientific reports Vol. 9; no. 1; p. 6821
• Main Authors: Ji, Yosep, Park, Soyoung, Chung, Youngmee, Kim, Bobae, Park, Haryung, Huang, Eunchong, Jeong, Dahye, Jung, Hoe-Yune, Kim, Bongjoon, Hyun, Chang-Kee, Holzapfel, Wilhelm H.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02-05-2019; Nature Publishing Group
• Subjects: 38/22; 38/77; 45/47; 631/326/2522; 631/45; 64/60; 82/80; 82/83; Adipocytes - metabolism; Adipose Tissue - metabolism; Animal models; Animals; Biomarkers; Body weight; Diet, High-Fat; Digestive system; Disease Models, Animal; Fatty acids; Fatty Acids, Volatile - metabolism; Gastrointestinal Microbiome; Gastrointestinal tract; High fat diet; Homeostasis; Humanities and Social Sciences; Intestinal microflora; Intestine; Lactobacillus sakei; Metabolic disorders; Metabolism; Mice; Mice, Obese; Microbiota; multidisciplinary; Obesity; Obesity - etiology; Obesity - metabolism; Probiotics; Science; Science (multidisciplinary); Weight Gain
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-019-43092-y

Recent progresses in clinical diagnostic analyses have demonstrated the decisive influence of host gut microbiota on the status of metabolic disorders. Short chain fatty acids (SCFAs) produced by gut microbiota, in particular, are considered as a key biomarker, both of communication between gut microbiota and the host, and of impact on host metabolic homeostasis. Microbiota modulation and concomitant anti-obesity effects of probiotics have been reported by different researchers. However, the underlying modulatory functions of probiotics on gut microbiota towards host metabolic homeostasis are still not fully understood. In this study, the impact of
Lactobacillus sakei
CJLS03 (isolated from Korean kimchi) on obesity-related biomarkers was investigated using a diet-induced obese mouse model. Body weight increase, SCFAs, the gut microbiota and various obesity-associated biomarkers were significantly and beneficially influenced by
L. sakei
CJLS03 administration compared to the control groups. Analytical data on faecal samples support the role of the colonic microbial population in SCFA production. The composition of the latter may be influenced by modulation of the distal gastro-intestinal microbiota by putative probiotics such as
L. sakei
CJLS03.