Structure Based Multitargeted Molecular Docking Analysis of Selected Furanocoumarins against Breast Cancer

Breast cancer is one of the biggest global dilemmas and its current therapy is to target the hormone receptors by the use of partial agonists/antagonists. Potent drugs for breast cancer treatment are Tamoxifen, Trastuzumab, Paclitaxel, etc. which show adverse effects and resistance in patients. The...

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Bibliographic Details
Published in:	Scientific reports Vol. 9; no. 1; pp. 15743 - 13
Main Authors:	Acharya, Reetuparna, Chacko, Shinu, Bose, Pritha, Lapenna, Antonio, Pattanayak, Shakti Prasad
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 31-10-2019 Nature Publishing Group
Subjects:	13/95 631/67 631/67/1347 692/4028/67/1347 Antagonists Binding Sites Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer therapies Catalytic Domain Drug Design Drug development Epidermal growth factor receptors ErbB Receptors - antagonists & inhibitors ErbB Receptors - metabolism Estrogen Receptor alpha - antagonists & inhibitors Estrogen Receptor alpha - metabolism Female Furanocoumarins Furocoumarins - chemistry Furocoumarins - metabolism Furocoumarins - therapeutic use Humanities and Social Sciences Humans Ligands MCF-7 Cells Menopause Molecular Docking Simulation Monoclonal antibodies multidisciplinary Paclitaxel Psoralen Science Science (multidisciplinary) Tamoxifen Targeted cancer therapy TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Trastuzumab
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